Pharmacokinetics and pharmacodynamics of epidural and intrathecal morphine

International Anesthesiology Clinics

Volumn 24, Issue 2, 1986, Pages 29-42

  Dahlström, Bengt ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

MORPHINE; MORPHINE 3 GLUCURONIDE;

ANALGESIA; BIOAVAILABILITY; CENTRAL NERVOUS SYSTEM; CEREBROSPINAL FLUID; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG CEREBROSPINAL FLUID LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG ELIMINATION; DRUG HALF LIFE; DRUG RESPONSE; DRUG STRUCTURE; DRUG THERAPY; EPIDURAL ANESTHESIA; HUMAN; INTRATHECAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; NORMAL HUMAN; PHARMACODYNAMICS; PHARMACOKINETICS; SHORT SURVEY; SPINAL ANESTHESIA; THERAPY;

ANESTHESIA, EPIDURAL; BIOLOGICAL AVAILABILITY; COMPARATIVE STUDY; DOSE-RESPONSE RELATIONSHIP, DRUG; HALF-LIFE; HUMAN; INJECTIONS, SPINAL; KINETICS; MORPHINE;

EID: 0022495673     PISSN: 00205907     EISSN: 15371913     Source Type: Journal    
DOI: 10.1097/00004311-198602420-00005     Document Type: Article

References (34)

1. Bromage PR, Camporesi EM, Durant PA, Nielsen CH: Influence of epinephrine as an adjuvant to epidural morphine. Anesthesiology 58:257, 1983
2. Brunk SF, Delle M: Morphine metabolism in man. Clin Pharmacol Ther 16:51, 1974
3. Brunk SF, Delle M, Wilson WR: Morphine metabolism in man: effect of guamethidine. J Clin Pharmacol 14:581, 1974
4. Chauvin M, Samii K, Schermann JM, et al: Plasma pharmacokinetics of morphine after i.m., extradural and intrathecal administration. Br J Anaesth 54:843, 1982
5. Dahlström B, Bolme P, Feychting H, et al: Morphine kinetics in children. Clin Pharmacol Ther 26:354, 1979
6. Dahlström B, Paalzow L: Pharmacokinetic interpretation of the enterohepatic recirculation and first-pass elimination of morphine in the rat. J Pharmacokenet Biopharm 6:505, 1978
7. Dahlström B, Tamsen A, Paalzow L, Hartvig P: Patient-controlled analgesic therapy. IV. Pharmacokinetics and analgesic plasma concentrations of morphine. Clin Pharmacokinet 7:266, 1982
8. Fichtel B, Kurz H: Binding of drugs to human muscle. Eur J Clin Pharmacol 14:335, 1978
9. Gustafsson LL, Friberg-Nilsson S, Gar le M, et al: Extradural and parenteral morphine: kinetics and effects in postoperative pain: a controlled clinical study. Br J Anaesth 54:1167, 1982
10. Gustafsson LL, Schildt B, Jacobsen K: Adverse effects of extradural and intrathecal opiates: report of a nationwide survey in Sweden. Br J Anaesth 54:479, 1982
11. Herz A, Teschemacher HJ: Activities and sites of antinociceptive action of morphine-like analgesics and kinetics of distribution following intravenous, intracerebral and intraventricular application, in Harper NJ, Simmonds AB (eds): Advances in Drug Research, Voi 6. New York: Academic, 1971, pp 79-119
12. Jörgensen BC, Andersen HB, Enquist A: CSF and plasma morphine after epidural and intrathecal application. Anesthesiology 55:714, 1981
13. Kaiko RF, Foley KM, Houde RW, Inturrisi CE: Narcotic levels in cerebrospinal fluid and plasma in man, in van REE JM, Terenius L (eds): Characteristics and Function of Opioids. Amsterdam: Elsevier, 1978, pp 221-222
14. Martin R, Salbaing J, Blaise G, et al: Epidural morphine for postoperative pain relief: a dose-response curve. Anesthesiology 56:423, 1982
15. Modig J, Paalzow L: A comparison of epidural morphine and epidural bupivacaine for postoperative pain relief. Acta Anaesthesiol Scand 25:437, 1981
16. Moore A, Bullingham R, McQuay H, et al: Spinal fluid kinetics of morphine and heroin. Clin Pharmacol Ther 35:40, 1984
17. Nayman J: Measurement and control of postoperative pain. Ann R Coll Surg Engl 61:419, 1979
18. Nordberg G, Hedner T, Mellstrand T, Borg L: Pharmacokinetics of epidural morphine in man. Eur J Clin Pharmacol 26:233, 1984
19. Nordberg G, Hedner T, Mellstrand T, Dahlström B: Pharmacokinetic aspects of epidural morphine analgesia. Anesthesiology 58:545, 1983
20. Nordberg G, Hedner T, Mellstrand T, Dahlström B: Pharma- Pharmacokinetics and Pharmacodynamics 41cokinetic aspects of intrathecal morphine analgesia. Anesthesiology 60:448, 1984
21. Olsen GD: Morphine binding to human plasma proteins. Clin Pharmacol Ther 17:31, 1975
22. Rawal N, Schott U, Dahlström B, et al: Inference of naloxone infusion on analgesia and respiratory depression following epidural morphine. Anesthesiology (in press, 1986)
23. Rawal N, Sjöstrand U, Dhalström B: Postoperative pain relief by epidural morphine. Anesth Analg (Cleve) 60:726, 1981
24. Säwe J, Dahlström B, Paalzow L, Rane A: Pharmacokinetics of morphine in cancer patients. Clin Pharmacol Ther 30:629, 1981
25. Stanski DR, Greenblatt DJ, Lappas DG, et al: Kinetics of high-dose intravenous morphine in cardiac surgery patients. Clin Pharmacol Ther 19:752, 1976
26. Stanski DR, Greenblatt DJ, Lowenstein E: Kinetics of intravenous and intramuscular morphine. Clin Pharmacol Ther 24:52, 1978
27. Strabe PJ, Downing JW, Brock-Utne JG: CSF pharmacokinetics of extradural morphine. Br J Anaesth 56:921, 1984
28. Weddel SJ, Ritter RR: Serum levels following epidural administrations of morphine and correlation with relief of postsurgical pain. Anesthesiology 54:210, 1981
29. Westerling D, Lindahl S, Andersson K-E, Andersson A: Absorption and bioavailability of rectally administered morphine in women. Eur J Clin Pharmacol 23:59, 1982
30. Yaksh T: Spinal opiate analgesia: characteristics and principles of action. Pain 11:293, 1981
31. Yaksh T, Rudy TA: Studies on the direct spinal action of narcotics in the production of analgesia in the rat. J Pharmacol Exp Ther 202:411, 1977
32. Yeung JC, Rudy TA: Sites of antinociceptive action of systemically injected morphine: involvement of supraspinal loci as revealed by intracerebroventricular injection of naloxone. J Pharmacol Exp Ther 215:626, 1980
33. Yeung JC, Rudy TA: Multiplicative interaction between narcotic agonism expressed at spinal and supraspinal sites of antinociceptive action as revealed by concurrent intrathecal and intracerebroventricular injections of morphine. J Pharmacol Exp Ther 215:633, 1980
34. Youngstrom PC, Cowan RI, Sutheimer C, et al: Pain relief and plasma concentrations from epidural and intramuscular morphine in postcesarean patients. Anesthesiology 57:404, 1982