SR-4233: A new bioreductive agent with high selective toxicity for hypoxic mammalian cells

International Journal of Radiation Oncology, Biology, Physics

Volumn 12, Issue 7 PART 1, 1986, Pages 1239-1242

  Zeman, Elaine M ^a   Brown, J Martin ^a   Lemmon, Marilyn J ^a   Hirst, V Kate ^a   Lee, William W ^b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SRI INTERNATIONAL   (United States)

Author keywords

Bioreductive cytotoxicity; Cytotoxicity; Reductive metabolism; SR 4233

Indexed keywords

3 AMINO 1,2,4 BENZOTRIAZINE 1 OXIDE; NEW DRUG; TIRAPAZAMINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; CELL CULTURE; CYTOTOXICITY; DRUG ANALYSIS; DRUG BLOOD LEVEL; DRUG CYTOTOXICITY; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG MECHANISM; DRUG METABOLISM; DRUG TISSUE LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HYPOXIA; IN VITRO STUDY; INTOXICATION; IRRADIATION; MOUSE; PRIORITY JOURNAL; RADIOSENSITIZATION;

ANIMALS; CELL LINE; COMBINED MODALITY THERAPY; CRICETINAE; FEMALE; HUMANS; MICE; MICE, INBRED C3H; NEOPLASM TRANSPLANTATION; NEOPLASMS, EXPERIMENTAL; OXYGEN; RADIATION-SENSITIZING AGENTS; TRIAZINES;

EID: 0022493495     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/0360-3016(86)90267-1     Document Type: Article

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