Lack of Cardiac Effect from Repeated Doses of Albuterol Aerosol: A Margin of Safety

Clinical Pediatrics

Volumn 25, Issue 7, 1986, Pages 349-352

  Lee, Haesoon ^a   Evans, Hugh E ^a  

^a SUNY DOWNSTATE MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PLACEBO; SALBUTAMOL;

ADVERSE DRUG REACTION; AEROSOL; ASTHMA; CENTRAL NERVOUS SYSTEM; CLINICAL ARTICLE; DRUG EFFICACY; DRUG SAFETY; DRUG THERAPY; FORCED EXPIRATORY VOLUME; GASTROINTESTINAL TOXICITY; HEART; HEART RATE; HEART RHYTHM; HUMAN; INHALATION; INHALATIONAL DRUG ADMINISTRATION; INTOXICATION; LUNG FUNCTION; NERVOUS SYSTEM; NERVOUSNESS; NEUROTOXICITY; PRIORITY JOURNAL; RESPIRATORY SYSTEM; STOMACH; STOMACH PAIN; THERAPY; THORAX TIGHTNESS; TREMOR;

ADOLESCENT; AEROSOLS; ALBUTEROL; ASTHMA; CHILD; DOUBLE-BLIND METHOD; FORCED EXPIRATORY VOLUME; HEART RATE; HUMAN; RANDOM ALLOCATION;

EID: 0022492364     PISSN: 00099228     EISSN: 19382707     Source Type: Journal    
DOI: 10.1177/000992288602500703     Document Type: Article

References (5)

1. Lee H., Izquierdo R., Evans HE Cardiac response to oral and aerosol administration of beta agonists. J Pediatr 1983; 103: 655-8.
2. Warrell DA, Robertson DG, Newton Howes J., et al. Comparison of cardiorespiratory effects of isoprenaline and salbutamol in patients with bronchial asthma. Br Med J 1970; 1: 65-70.
3. Barclay J., Smith Wgj, Addis GJ Asthma deaths and theophylline/beta2—agonist therapy (letter). Lancet 1981; 2: 369-70.
4. Barclay J., Whiting B., Meredith PA, et al. Theophylline-salbutamol interaction: bronchodilator response to salbutamol at maximally effective plasma theophylline concentrations. Br J Clin Pharmacol 1981; 11: 203-8.
5. Repsher LH, Anderson JA, Bush RK, et al. Assessment of tachyphylaxis following prolonged therapy of asthma with inhaled albuterol aerosol. Chest 1984;85: 34-38.