Kinetics of antimicrobial activity

The Journal of Pediatrics

Volumn 108, Issue 5 PART 2, 1986, Pages 835-840

  Vogelman, Bennett ^a,b   Craig, William A ^a,b  

^a WILLIAM S MIDDLETON MEMORIAL VETERANS HOSPITAL   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; BETA LACTAM ANTIBIOTIC; CEFALOTIN; CEFOPERAZONE; CHLORAMPHENICOL; ERYTHROMYCIN; GENTAMICIN; IMIPENEM; METICILLIN; PENICILLIN G; PIPERACILLIN; QUINOLONE DERIVATIVE; RIFAMPICIN; TETRACYCLINE; TRIMETHOPRIM; VANCOMYCIN;

ANIMAL; ANIMAL EXPERIMENT; ANIMAL MODEL; DRUG ADMINISTRATION; DRUG COMPARISON; DRUG DOSE; DRUG EFFICACY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PHARMACOKINETICS; PRIORITY JOURNAL;

AMINOGLYCOSIDES; ANIMAL; ANTIBIOTICS; ANTIBIOTICS, LACTAM; BACTERIA; DRUG ADMINISTRATION SCHEDULE; HUMAN; KINETICS; MICROBIAL SENSITIVITY TESTS; TIME FACTORS;

EID: 0022491927     PISSN: 00223476     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-3476(86)80754-5     Document Type: Article

References (20)

1. Effect of schedule of administration on the therapeutic efficacy of penicillin
2. On the duration of penicillin action in relation to its concentration in the serum
3. The rate of bactericidal action of penicillin in vitro as a function of its concentration and its paradoxically reduced activity at high concentrations against certain organisms
4. Efficacy of intermittent versus continuous administration of netilmicin in a two-compartment in vitro model
5. Impact of dosing intervals on activity of gentamicin and ticarcillin against Pseudomonas aeruginosa in granulocytopenic mice
6. Bactericidal activity of cephalosporins in an in vitro model simulating serum levels
7. New in vitro model to study the effect of antibiotic concentration and rate of elimination on antibacterial activity
8. Use of animal models of meningitis in developing therapeutic strategies
9. Time course of the pharmacological response to beta-lactam antibiotics in vitro and in vivo
10. Cefazolin and cephradine: relationship between antibacterial activity in vitro and in mice experimentally infected with Escherichia coli
11. Dosis-wirkungs-beziehung der bakterizidie bei E. coli, K. pneumoniae und Staphylococcus aureus
12. Effects of subminimum inhibitory concentrations of antibiotics on bacteria
13. Postantibiotic effect
14. The postantibiotic effect
15. Efficacy of continuous versus intermittent administration of penicillin G in Streptococcus pneumoniae pneumonia in normal and immunodeficient rats
16. Therapeutic efficacy of continuous versus intermittent administration of ceftazidime in experimental Klebsiella pneumoniae pneumonia in rats
17. Combination antibiotic therapy: comparison of constant infusion and intermittent bolus dosing in an experimental animal model
18. Once-daily vs. continuous aminoglycoside dosing: efficacy and toxicity in animal and clinical studies of gentamicin, netilmicin and tobramycin
19. Third-generation cephalosporins in the treatment of pneumonia due to Pseudomonas aeruginosa in guinea pigs
20. Cefotaxime compared with nafcillin plus tobramycin for serious bacterial infections