Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185

Cell

Volumn 45, Issue 5, 1986, Pages 649-657

  Bargmann, Cornelia I ^a,b   Hung, Mien Chie ^a,b   Weinberg, Robert A ^a,b  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT;

ANIMAL CELL; CELL LINE; GENE ACTIVATION; GENETIC ENGINEERING; GENETIC RECOMBINATION; HEREDITY; NONHUMAN; ONCOGENE; PLASMID; POINT MUTATION; PRIORITY JOURNAL; RAT;

ALLELES; ANIMAL; CELL LINE; CELL TRANSFORMATION, NEOPLASTIC; DNA; ETHYLNITROSOUREA; GENE EXPRESSION REGULATION; MICE; MUTATION; ONCOGENES; PROTEIN CONFORMATION; PROTO-ONCOGENE PROTEINS; RATS; RATS, INBRED STRAINS; RECEPTOR, ERBB-2; RECEPTORS, CELL SURFACE; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0022485548     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(86)90779-8     Document Type: Article

References (46)

1. Structural requirements of a membrane-spanning domain for protein anchoring and cell surface transport
2. Mouse skin carcinomas induced in vivo by chemical carcinogens have a transforming Harvey-ras oncogene
3. The neu oncogene encodes an epidermal growth factor receptor-related protein
4. Viral oncogenes
5. Amino-acid substitutions at codon 13 of the N-ras oncogene in human acute myeloid leukaemia
6. Activation of Ki-ras2 gene in human colon and lung carcinomas by two different point mutations
7. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
8. Molecular cloning of a new transforming gene from a chemically transformed human cell line
9. Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene
10. Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences
11. Monoclonal antibodies identify a cell-surface antigen associated with an activated cellular oncogene
12. Down-modulation of an oncogene protein product and reversion of the transformed phenotype by monoclonal antibodies
13. Studies on the light-transducing pigment bacteriorhodopsin
14. A molecular approach to leukemogenesis: mouse lymphomas contain an activated c-ras oncogene
15. Activation of a c-K-ras oncogene by somatic mutation in mouse lymphomas induced by gamma radiation
16. Loss of the normal N-ras allele in a mouse thymic lymphoma induced by a chemical carcinogen
17. Molecular cloning of the neu gene: absence of gross structural alteration in oncogenic alleles
18. Polypeptide growth factors
19. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
20. A mutation in the β-globin gene detected in the progeny of a female mouse treated with ethylnitrosourea
21. Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumors of glial origin
22. Sequencing end-labeled DNA with base-specific chemical cleavages
23. Expression of functional acetylcholine receptors from cloned cDNAs
24. Sequence and structure of a human glucose transporter
25. Synthesis of rabbit β-globin in cultured monkey kidney cells following infection with an SV40 β-globin recombinant genome
26. Primary structure of Electrophorus electricus sodium channel deduced from cDNA sequence
27. Identification of a phosphoprotein specifically induced by the transforming DNA of rat neuroblastomas
28. Analysis of a mouse α-globin gene mutation induced by ethylnitrosourea
29. c-erbB activation in avian leukosis virus-induced erythroblastosis: clustered integration sites and the arrangement of provirus in the c-erbB alleles
30. Structural modifications and repair of DNA in neuro-oncogenes by N-ethyl-N-nitrosourea
31. Nervous-system-specific carcinogenesis by ethylnitrosourea in the rat: molecular and cellular aspects
32. r tumor antigen
33. The neu gene: an erbB-homologous gene distinct from and unlinked to the gene encoding the EGF receptor
34. Clonal cell lines from the rat central nervous system
35. The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF-1
36. Transforming genes of carcinomas and neuroblastomas introduced into mouse fibroblasts
37. Fused transcript of abl and bcr genes in chronic myelogenous leukaemia
38. Chemical Mutagenesis
39. Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter
40. p185, product of the neu proto-oncogene, is a receptor-like protein associated with tyrosine kinase activity
41. Induction of mammary carcinomas in rats by nitroso-methylurea involves malignant activation of H-ras-1 locus by single point mutations
42. Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells
43. The molecular genetics of cellular oncogenes
44. Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor
45. Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats