Covalent binding of a fluorinated 2-nitroimidazole to emt-6 tumors in Balb/C mice: detection by f-19 nuclear magnetic resonance at 2.35 T

International Journal of Radiation Oncology, Biology, Physics

Volumn 12, Issue 7 PART 1, 1986, Pages 1243-1245

  Raleigh, James A ^a   Franko, Allan J ^a   Treiber, Erich O ^a   Lun, J Andrew ^a   Allen, Peter S ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

F 19 nuclear magnetic resonance; Fluorinated 2 nitroimidazole; Hypoxic cell binding

Indexed keywords

1 (1,1,1,3,3,3 HEXAFLUORO 2 PROPOXY) 3 (2 NITRO 1 IMIDAZOLYL) 2 PROPANOL; 2 NITROIMIDAZOLE; 2 NITROIMIDAZOLE DERIVATIVE; 3 (1,1,1,3,3,3 HEXAFLUOROPROPOXY) 1 (2 NITRO 1 IMIDAZOLYL) 2 PROPANOL; 3 (1,1,1,3,3,3 HEXAFLUOROPROPOXY) 1 (2 NITRO 1 IMIDAZOLYL) 2 PROPANOL H 3; CCI 103F H 3; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD AND HEMOPOIETIC SYSTEM; CANCER GRAFT; CYTOLOGY; DIAGNOSIS; DRUG ANALYSIS; DRUG BINDING; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG IDENTIFICATION; DRUG SYNTHESIS; DRUG TISSUE LEVEL; DRUG TOXICITY; EMT 6 TUMOR; FLUORINATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPOXIA; INTOXICATION; LIVER; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL;

ANIMALS; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MICE, INBRED BALB C; NEOPLASM TRANSPLANTATION; NEOPLASMS, EXPERIMENTAL; NITROIMIDAZOLES; OXYGEN;

EID: 0022485265     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/0360-3016(86)90268-3     Document Type: Article

References (12)

1. The synthesis of tritium-labelled misonidazole
2. Pharmacokinetic considerations in radiosensitizer development
3. The cellular basis of radiotherapeutic response
4. A marker for hypoxic cells with potential clinical applicability
5. Hypoxic fraction and binding of misonidazole in EMT6/Ed multicellular tumor spheroids
6. A new substituent constant, τ derived from partition coefficients
7. Changes in misonidazole binding with hypoxic fraction in mouse tumors
8. Variation in normal and tumor tissue sensitivity of mice to ionizing radiation-induced DNA strand breaks in vivo
9. Intracellular localization of radioactively labelled misonidazole in EMT6 tumor cells in vitro
10. Structure function dependence and allopurinol inhibition of radiosensitizer/nitroreductase interaction
11. The chemistry of nitroimidazole hypoxic cell radiosensitizers
12. Clinical studies with misonidazole