Subcutaneous heparin treatment of deep venous thrombosis: A comparison of unfractionated and low molecular weight heparin

Pathophysiology of Haemostasis and Thrombosis

Volumn 16, Issue , 1986, Pages 30-37

  Holm, H A ^a   Ly, B ^b   Handeland, G F ^a   Abildgaard, U ^a   Arnesen, K E ^c   Gottschalk, P ^c   Hoeg V ^a   Aandahl, M ^c   Haugen, K ^b   Laerum F ^a   Scheel, B ^a   Sortland, O ^c   Vinje, B ^b  

^a AKER UNIVERSITY HOSPITAL   (Norway)

^b LOVISENBERG DIAKONALE HOSPITAL   (Norway)

^c AKERSHUS UNIVERSITY HOSPITAL   (Norway)

Author keywords

Deep venous thrombosis; Heparin; Heparin assays; Heparin treatment; Low molecular weight; Subcutaneous

Indexed keywords

DALTEPARIN; HEPARIN; LOW MOLECULAR WEIGHT HEPARIN; NEW DRUG; WARFARIN;

ADVERSE DRUG REACTION; BLEEDING; BLOOD AND HEMOPOIETIC SYSTEM; CLINICAL ARTICLE; DEEP VEIN THROMBOSIS; DRUG COMPARISON; DRUG EFFICACY; DRUG THERAPY; HUMAN; LUNG EMBOLISM; PERIPHERAL VASCULAR SYSTEM; RESPIRATORY SYSTEM; SUBCUTANEOUS DRUG ADMINISTRATION; THERAPY;

ADULT; AGED; CLINICAL TRIALS; DOUBLE-BLIND METHOD; FACTOR X; FACTOR XA; FEMALE; HEPARIN; HUMANS; INJECTIONS, SUBCUTANEOUS; MALE; MIDDLE AGED; MOLECULAR WEIGHT; THROMBOPHLEBITIS;

EID: 0022485055     PISSN: 14248832     EISSN: 14248840     Source Type: Journal    
DOI: 10.1159/000215355     Document Type: Article

References (22)

1. Holm, H.A.; Abildgaard. U.; Kalvenes, S.; An-dcrsscn, N.; Anker, E.; Arnesen. K.E., Blikom. D.; Drivenes, A.: The antithrombotic effect of heparin in deep venous thrombosis: relation to four heparin assays. Acta med. scand, 215: 47-53 (1984).
2. Holm, H.A.; Abildgaard. U.; Kalvenes. S.: Heparin assays and bleeding complications in treatment of deep venous thrombosis with particular reference to retroperitoneal bleeding. Thromb. Haemostasis 53: 278-281 (1985).
3. Bentley. P.G.; Kakkar, V.V.; Scully, M.F.; Mac-Gregor. I.R.; Webb, P.; Chan, P.; Jones, N.: An objective study of alternative methods of heparin administration. Thromb. Res. 18: 177-187 (1980).
4. Andersson, G.; Fagrell, B.; Holmgren, K.; Johns-son, H.; Ljungberg, B.; Nilsson, E.; Wilhelmsson, S.; Zetterquist, S.: Subcutaneous administration of heparin. A randomized comparison with intravenous administration of heparin to patients with deep-vein thrombosis. Thromb. Res. 27: 631-639 (1982).
5. Pini, M; Poli, T.; Tagliaferri, A.; Poti, R.; Quin-tavalla, R,; Dcttori, A.G.: Subcutaneous versus intravenous heparin in the treatment of deep venous thrombosis. Thromb. Haemostasis 54: 28 (1985).
6. Thomas, D.P.; Merton, R.E.; Lewis, W.E.; Bar-rowcliffe. T.W.: Studies in man and experimental animals of a low molecular weight heparin fraction, Thromb. Res. 45: 214-218 (1981).
7. Holmer. E.; Mattson, C; Nilsson, S.: Anticoagulant and antithrombotic effects of heparin and low molecular weight heparin fragments in rabbits. Thromb. Haemostasis 25: 475-485 (1982).
8. Carter, C.J.; Kelton, J.G.; Hirsch, A.; Cerskus, A.: Santos, A.V.; Gent, M. The relationship between the hemorrhagic and antithrombotic properties of low molecular weight heparin in rabbits. Blood 59: 1239-1245 (1982).
9. Salzman. E.W.; Rosenberg, R.D.; Smith, M.H.; Lindon, J.N.; Favreau, L.: Effect of heparin and heparin fractions on platelet aggregation. J. clin. Invest, 65: 69 (1980).
10. De Swan, C.A.M.; Sixma, J.J.; Andersson, L.O.; Holmer, E,; Verschoor, L,; Nijmeijer, A.: Kinetics in normal humans of anticoagulant activity, radioactivity and lipolytic activity after intravenous administration of (S35) heparin and (S35) heparin fractions. Scand. J. Haematol. 25: suppl. 36, pp. 50-63 (1980).
11. Kakkar, V.V.; Djazaeri, B.; Fok, J.; Scully, M.E.; Westwick, J,: Low-molecular weight heparin and prevention of postoperative deep vein thrombosis. Br. med. J. 284: 375-379(1982).
12. Schmilz-Hucbner, V,; Bünte, H.; Freise, G.; Keers, B.; Rüschemeyer, C; Scherer, R.; Schulte, H.; Loo, J. van de: Clinical efficacy of low molecular weight heparin in postoperative thrombosis prophylaxis. Klin. Wschr. 62: 349-353 (1984)
13. Thomas. D.P.: Merton, R.E.: A low molecular weight heparin compared with unfractionatcd heparin. Thromb. Res. 28: 343-350 (1982).
14. Bratt, G.; Tørnebohm. E,; Widlund. L; Lockner, D.: Low molecular weight heparin (Kabi 2165, Fragmin): Pharmacokinetics after intravenous and subcutaneous administration in human volunteers. Thromb. Res. 42: 613-620 (1986).
15. Rabinov, K.: Paulin. S.: Roentgen diagnosis of venous thrombosis in the leg. Archs Surg. 104: 134-144 (1972).
16. Mardcr, V.J.; Soulen, R.L.: Atkharlakarn. V.: Budzynski, A.Z.: Parulckar, S,; Kim, J.R.; Edward, N.: Zahavi, J.; Algazy. K.M.: Quantitative venography assesment of deep vein thrombosis in the evaluation of streptokinase and heparin therapy. J. Lab. clin. Med. 84: 1018-1029 (1977).
17. Handeland, G.: Simplified chromogenic substrate assay for low molecular weight heparin. Thromb. Res, 42: 105-108 (1986).
18. Bara, L.: Billand. E.; Gramond, G.; Samana, M.: Comparative pharmacokinetics of a low molecular weight heparin (PK 10169) and unfractionatcd heparin (UH) after intravenous and subcutaneous administration. Thromb. Haemostasis 54: 309 (1985).
19. Marciniak. E.; Gockcrman, J.P.: Heparin-induced decrease in circulating antithrombin - III. Lancet ii: 581-585 (1977).
20. Holn, H.A.; Kalvenes, S.; Abildgaard. U.: Changes in plasma antithrombin (heparin cofactor activity) during intravenous heparin therapy: observations in 198 patients with deep venous thrombosis. Scand. J. Haematol, (in press, 1986).
21. Holm, H.A.; Finnangcr, B.: Hartmann. A., Lae-rum, F.: Løhren, O.; Ruud, T.E.; Stray, N.; Wol-land T.: Heparin treatment of deep venous thrombose in 280 patients: symptoms related to dosage. Acta. med. scand, 215: 47-53 (1984).
22. Holmer. E.; Kurachi. K.; Søderstrøm, G.: The molecular weight dependence of the rate-enhancing effect of heparin on the inhibition of thrombin, factor Xa, factor IXa. factor XIa, factor Xlla and kallikrein by antithrombin. Biochcm. J. 193: 395-400(1981)