Molecular Cloning of a Human Prion Protein cDNA

DNA

Volumn 5, Issue 4, 1986, Pages 315-324

  Kretzschmar, Hans A ^a   Stowring, Linda E ^a   Westaway, David ^a   Stubblebine, William H ^a   Prusiner, Stanley B ^a   Dearmond, Stephen J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; RADIOISOTOPE;

CELL METABOLISM; CENTRAL NERVOUS SYSTEM; CREUTZFELDT JAKOB DISEASE; GENETIC ENGINEERING; HUMAN; MOLECULAR CLONING; NERVOUS SYSTEM; NUCLEIC ACID HYBRIDIZATION; PRION; SCRAPIE;

AMINO ACID SEQUENCE; ANIMALS; CLONING, MOLECULAR; CRICETINAE; DNA; HUMANS; MELANOMA; NERVE TISSUE PROTEINS; PRIONS; RETINOBLASTOMA; RNA, MESSENGER; SEQUENCE HOMOLOGY, NUCLEIC ACID;

ANIMALIA; CRICETINAE;

EID: 0022477981     PISSN: 01980238     EISSN: 15577430     Source Type: Journal    
DOI: 10.1089/dna.1986.5.315     Document Type: Article

References (51)

1. BARRY, R.A., and PRUSINER, S.B. (1986). Monoclonal antibodies to the cellular and scrapie prion protein. J. Infect. Dis. (in press).
2. BARRY, R.A., KENT, S.B.H., McKINLEY, M.P., MEYER, R.K., DEARMOND, S.J., HOOD, L.E., and PRUSINER, S.B. (1986). Scrapie and cellular prion proteins share polypeptide epitopes. J. Infect. Dis. 153, 848–854.
3. BECK, E., and DANIEL, P.M. (1979). Kuru and Creutzfeldt-Jakob disease: neuropathological lesions and their significance. In Slow Transmissible Diseases of the Nervous System, 1, S.B. Prusiner and W.J. Hadlow, Eds. (Academic Press: New York) pp. 253–270.
4. BENDHEIM, P.E., BARRY, R.A., DEARMOND, S.J., STITES, D.P., and PRUSINER, S.B. (1984). Antibodies to a scrapie prion protein. Nature 310, 418–421.
5. BIGGIN, M.D., GIBSON, T.J., and HONG, G.F. (1983). Buffer gradient gels and 35S label as an aid to rapid DNA sequence determination. Proc. Natl. Acad. Sci. USA 80, 3963–3965.
6. BOCKMAN, J.M., KINGSBURY, D.T., McKINLEY, M.P., BENDHEIM, P.E., and PRUSINER, S.B. (1985). Creutzfeldt-Jakob disease prion proteins in human brains. N. Engl. J. Med. 312, 73–78.
7. BOLTON, D.C., McKINLEY, M.P., and PRUSINER, S.B. (1982). Identification of a protein that purifies with the scrapie prion. Science 218, 1309–1311.
8. CHEN, E.Y., and SEEBURG, P.H. (1985). Supercoil sequencing: A fast and simple method for sequencing plasmid DNA. DNA 4, 165–170.
9. CHESEBRO, B., RACE, R., WEHRLY, K., NISHIO, J., BLOOM, M., LECHNER, D., BERGSTROM, S., ROBBINS, K., MAYER, L., KEITH, J.M., GARON, C, and HAASE, A. (1985). Identification of scrapie prion protein-specific mRNA in scrapie-infected and uninfected brain. Nature 315, 331–333.
10. CHOU, S.M., PAYNE, W.N., GIBBS, C.J., and GAJDUSEK, D.C. (1980). Transmission and scanning electron microscopy of spongiform change in Creutzfeldt-Jakob disease. Brain 103, 885–904.
11. CONRAD, B., and MOUNT, D.W. (1982). Microcomputer programs for DNA sequence analysis. Nucleic Acids Res. 10, 31–38.
12. DALE, R.M.K., McCLURE, B.A., and HOUCHINS, J.P. (1985). A rapid single-stranded cloning strategy for producing a sequential series of overlapping clones for use in DNA sequencing: Application to sequencing the corn mitrochondria 18S rDNA. Plasmid 13, 31–40.
13. DEARMOND, S.J., McKINLEY, M.P., BARRY, R.A., BRAUNFELD, M.B., McCOLLOCH, J.R., and PRUSINER, S.B. (1985). Identification of prion amyloid filaments in scrapie-infected brain. Cell 41, 221–235.
14. FIELDS, S., and WINTER, G. (1981). Nucleotide-sequence heterogeneity and sequence rearrangements in influenza virus cDNA. Gene 15, 207–214.
15. FORNWALD, J.A., KUNCIO, G., PENG, I., and ORDAHL, C.P. (1982). The complete nucleotide sequence of the chick a-actin gene and its evolutionary relationship to the actin gene family. Nucleic Acids Res. 10, 3861–3875.
16. GAJDUSEK, D.C. (1977). Unconventional viruses and the origin and disappearance of kuru. Science 197, 943–960.
17. HADLOW, W.J. (1959). Scrapie and kuru. Lancet ii, 289–290.
18. HUYNH, T., YOUNG, R., and DAVIS, R.W. (1985). Constructing and screening cDNA libraries in λgtlO and λgt1l. In DNA Cloning–A Practical Approach, 1, D. Glover, Ed. (IRL Press: Oxford and Washington, D.C.) pp. 49–78.
19. KASPER, K.C., STITES, D.P., BOWMAN, K.A., PANITCH, H., and PRUSINER, S.B. (1982). Immunological studies of scrapie infection. J. Neuroimmunol. 3, 187–201.
20. KITAMOTO, T., TATEISHI, J., TASHIMA, T., TAKESHITA, I., BARRY, R.A., DEARMOND, S.J., and PRUSINER, S.B. (1986). Amyloid plaques in Creutzfeldt-Jakob disease stain with prion protein antibodies. Ann. Neurol. (in press).
21. KOZAK, M. (1983). Comparison of initiation of protein synthesis in procaryotes, eucaryotes, and organelles. Microbiol. Rev. 47, 1–45.
22. KRETZSCHMAR, H.A., PRUSINER, S.B., STOWRING, L.E., and DEARMOND, S.J. (1986). Scrapie prion proteins are synthesized in neurons. Am. J. Pathol. 122, 1–5.
23. LINKE, R.P. (1981). Amphipathic properties of the low molecular weight component of. serum amyloid-A protein shown by charge-shift electrophoresis. Biochim. Biophys. Acta 668, 388–396.
24. McKINLEY, M.P., BOLTON, D.C., and PRUSINER, S.B. (1983). A protease-resistant protein is a structural component of the scrapie prion. Cell 35, 57–62.
25. MASTERS, C.L., GAJDUSEK, D.C., and GIBBS, C.J., Jr. (1981). Creutzfeldt-Jakob disease virus isolations from the Gerstmann-Sträussler syndrome. Brain 104, 559–588.
26. MEYER, R.K., McKINLEY, M.P., BOWMAN, K.A., BARRY, R.A., and PRUSINER, S.B. (1986). Separation and properties of cellular and scrapie prion proteins. Proc. Natl. Acad. Sci. USA 83, 2310–2314.
27. NATHANS, J., and HOGNESS, D.S. (1983). Isolation, sequence analysis, and introexon arrangement of the gene encoding bovine rhodopsin. Cell 34, 807–814.
28. NATHANS, J., THOMAS, D., and HOGNESS, D.S. (1986). Molecular genetics of human color vision: the genes encoding blue, green and red pigments. Science 232, 193–202.
29. NORRANDER, J., KEMPE, T., and MESSING, J. (1983). Construction of improved M13 vectors using oligodeoxynucleotide directed mutagenesis. Gene 26, 101–106.
30. OESCH, B., WESTAWAY, D., WÄLCHLI, M., McKINLEY, M.P., KENT, S.B.H., AEBERSOLD, R., BARRY, R.A., TEMPST, P., TEPLOW, D.B., HOOD, L.E., PRUSINER, S.B., and WEISSMANN, C (1985). A cellular gene encodes scrapie PrP 27–30 protein. Cell 40, 735–746.
31. PROUDFOOT, N.J., and BROWNLEE, G.G. (1976). 3′ Noncoding region sequences in eukaryotic messenger RNA. Nature 263, 211–214.
32. PRUSINER, S.B. (1982). Novel proteinaceous infectious particles cause scrapie. Science 216, 136–144.
33. PRUSINER, S.B., BOLTON, D.C., GROTH, D.F., BOWMAN, K.A., COCHRAN, S.P., and McKINLEY, M.P. (1982). Further purification and characterization of scrapie prions. Biochemistry 21, 6942–6950.
34. PRUSINER, S.B., GROTH, D.F., BOLTON, D.C., KENT, S.B., and HOOD, L.E. (1984). Purification and structural studies of a major scrapie prion protein. Cell 38, 127–134.
35. PRUSINER, S.B., McKINLEY, M.P., BOWMAN, K.A., BOLTON, D.C., BENDHEIM, P.E., GROTH, D.F., and GLENNER, G.G. (1983). Scrapie prions aggregate to form amyloidlike birefringent rods. Cell 35, 349–358.
36. RIGBY, P.W.J., DIECKMANN, M., RHODES, C, and BERG, P. (1977). Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I.J. Mol. Biol. 113,237–251.
37. SABATINI, D.D., KREIBACH, G., MORIMOTO, T., and ADESNIK, M. (1982). Mechanisms for the incorporation of proteins in membranes and organelles. J. Cell Biol. 92, 1–22.
38. SANGER, T., NICKLEN, S., and COULSON, A.R. (1977). DNA sequencing with chain-termination inhibitors. Proc. Natl. Acad. Sci. USA 74, 5463–5467.
39. SCHWAB, M., ELLISON, J., BUSCH, M., ROSEMAN, W., VARMUS, H.E., and BISHOP, J.M. (1984). Enhanced expression of the human gene N-myc consequent to amplification of DNA may contribute to malignant progression of neuroblastoma. Proc. Natl. Acad. Sci. USA 81, 4940–4944.
40. SEGREST, J.P., JACKSON, R.L., MORRISETT, J.D., and GOTTO, A.M., Jr. (1974). A molecular theory of lipid-protein interactions in the plasma lipoproteins. FEBS Lett. 38, 247–253.
41. SEGREST, J.P., POWNALL, H.J., JACKSON, R.L., GLENNER, G.G., and POLLOCK, P.S. (1976). Amyloid A: Amphipathic helixes and lipid binding. Biochemistry 15, 3187–3191.
42. SHANK, P.R., HUGHES, S.H., KUNG, H.-J., MAJORS, J.E., QUINTRELL, N., GUNTAKA, R.V., BISHOP, J.M., and VARMUS, H.E. (1978). Mapping integrates avian sarcoma virus DNA: Termini of linear DNA bear 300 nucleotides present once or twice in two species of circular DNA. Cell 15, 1383–1395.
43. SIMONSEN, C.C., and LEVINSON, A.D. (1983). Analysis of processing and polyadenylation signals of the hepatitis B virus surface antigen gene by using simian virus 40-hepatitis-B virus chimeric plasmids. Mol. Cell Biol. 3, 2250–2258.
44. SPARKES, R.S., SIMON, M., COHN, V.H., FOURNIER, R.E.K., LEM, J., KLISAK, I., HEINZMANN, C, BLATT, C, LUCERO, M., MOHANDAS, T., DEARMOND, S.J., WESTAWAY, D.A., PRUSINER, S.B., and WEINER, L.P. (1986). Assignment of the human and mouse prion protein gene to homologous chromosomes. Proc. Natl. Acad. Sci. USA (in press).
45. THOMAS, P.S. (1980). Hybridization of denatured RNA and small DNA fragments to nitrocellulose. Proc. Natl. Acad. Sci. USA 77, 5201–5205.
46. VIEIRA, J., and MESSING, J. (1982). The pUC plasmids an M13 mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers. Gene 19, 259–268.
47. VOLCKAERT, G., TAVERNIER, J., DERYNCK, R., DEVOS, R., and FIERS, W. (1981). Molecular mechanisms of nucleotide rearrangements in cDNA clones of human fibroblast interferon in RNA. Gene 15, 215–223.
48. von HEIJNE, G. (1983). Patterns of amino acids near signal-sequence cleavage sites. Eur. J. Biochem. 133, 17–21.
49. von HEIJNE, G. (1985). Signal sequences. The limits of variation. J. Mol. Biol. 184, 99–105.
50. WESTAWAY, D., and PRUSINER, S.B. (1986). Conservation of the cellular gene encoding the scrapie prion protein. Nucleic Acids Res. 14, 2035–2044.
51. ZLOTNIK, I., and STAMP, J.L. (1961). Scrapie disease of sheep. World Neurol. 2, 895–907.