Nitrobenzyl Derivatives as Bioreductive Alkylating Agents: Evidence for the Reductive Formation of a Reactive Intermediate

Journal of Medicinal Chemistry

Volumn 29, Issue 10, 1986, Pages 2048-2052

  Kirkpatrick, D L ^a   Johnson, K E ^a   Sartorelli, A C ^b  

^a UNIVERSITY OF REGINA   (Canada)

^b YALE CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MORPHOLINE; THIOGUANINE DERIVATIVE; TIOGUANINE;

2 NITROBENZYL CHLORIDE; 4 NITROBENZYL CHLORIDE; BIOLOGICAL MODEL; DOSE RESPONSE; DRUG ANALYSIS; DRUG COMPARISON; DRUG CYTOTOXICITY; DRUG IDENTIFICATION; DRUG INTERACTION; DRUG RESPONSE; DRUG SCREENING; DRUG SYNTHESIS; ELECTRON SPIN RESONANCE; EMT 6 TUMOR; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPOXIA; IN VITRO STUDY; INTOXICATION; N METHYLCARBAMIC ACID 2 NITROBENZYL ESTER; N METHYLCARBAMIC ACID 4 NITROBENZYL ESTER; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; S (2 AMINOBENZYL)THIOGUANINE; S (2 NITROBENZYL)THIOGUANINE; S (3 NITROBENZYL)THIOGUANINE; S (4 NITROBENZYL)THIOGUANINE; STRUCTURE ACTIVITY RELATION;

ALKYLATING AGENTS; ANTINEOPLASTIC AGENTS; BIOTRANSFORMATION; CELL SURVIVAL; CELLS, CULTURED; OXIDATION-REDUCTION; SUPPORT, NON-U.S. GOV'T;

EID: 0022475961     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00160a043     Document Type: Article

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