Human tumor xenografts treated with recombinant human tumor necrosis factor alone or in combination with interferons

Cancer Research

Volumn 46, Issue 8, 1986, Pages 3990-3993

  Balkwill, Frances R ^a   Lee, Audrey ^a   Aldam, Gary ^a   Moodie, Elaine ^a   Thomas, J Alero ^a   Tavernier, Jan ^b   Fiers, Walter ^c  

^a Imperial Cancer Research Fund Lincoln's Inn Fields ^*  (Kiribati)

^b Biogent ^*  (Belgium)

^c Laboratory of Molecular Biology ^*  (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHAN1 INTERFERON; GAMMA INTERFERON; INTERFERON; RECOMBINANT GAMMA INTERFERON; TUMOR NECROSIS FACTOR;

ANIMAL EXPERIMENT; BREAST; CANCER CHEMOTHERAPY; CANCER GROWTH; DIGESTIVE SYSTEM; DRUG COMPARISON; DRUG EFFICACY; DRUG MIXTURE; HISTOLOGY; HISTOPATHOLOGY; HUMAN; HUMAN CELL; INTRATUMORAL DRUG ADMINISTRATION; METHODOLOGY; MOUSE; NUDE MOUSE; PRIORITY JOURNAL; THERAPY; TUMOR CELL LINE; TUMOR REGRESSION; TUMOR XENOGRAFT; XENOGRAFT;

ANIMALS; FEMALE; GLYCOPROTEINS; HUMANS; INTERFERONS; MICE; NEOPLASM TRANSPLANTATION; NEOPLASMS, EXPERIMENTAL; RECOMBINANT PROTEINS; TRANSPLANTATION, HETEROLOGOUS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0022470478     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Old, L.J. Tumor necrosis factor (TNF). Science (Wash. DC), 230: 630-632, 1985.
2. Carswell, E.A., Old, L.J., Kassel, R.J., Green, S., Fiore, N., and Williamson, B. An endotoxin-induced serum factor that causes necros of tumors. Proc. Natl. Acad. Sci. USA, 72: 3666-3670, 1970.
3. Ruff, M.R., and Gilford, G.D. Tumor necrosis factor. In: E. Pick (ed.), Lymphokines, Vol. 2, pp. 235-269. New York: Academic Press, Inc., 1981.
4. Fransen, L., Van Der Heyden, J., Ruysschaert, R., and Fiers, W. Recombinant tumor necrosis factor: its effect and its synergism with interferon; on a variety of normal and transformed human and mouse cell lines. Eur. J. Cancer Clin. Oncol., 22: 419-426, 1986.
5. Williamson, B.D., Carswell, E.A., Rubin, B.Y., Predergast, J.S., and Old, L.J. Human tumor necrosis factor produced by B-cell lines: synergistic cytotoxic interferon. Proc. Natl. Acad. Sci. USA, 80: 5397-5401, 1982.
6. Beutler, B., Greenwold, D., Hulmes, J.D., Change, M., Pan, Y.C.E., Mathison, J., Ulevitch, R., and Cerami, A. Identity of tumor necrosis factor and the macrophage-secreted factor cachetin. Nature (Lond.), 316: 552-554, 1985.
7. Shalaby, M.R., Aggarwal, B.B., Rinderknecht, R., Svedarsky, L.P., Finkle, B.S., and Palladino, M.A. Activation of human polymorphonuclear neutrophil functions by interferon and tumor necrosis factors. J. Immunol., 135: 2069-2073, 1985.
8. Collins, T., La Pierre, L.A., Fiers, W., Strominger, E.L., and Pober, J.S. Recombinant human tumor necrosis factor increases mRNA levels and surface expression of HLA A, B antigen in vascular endothelial cells and dermal fibroblasts in vitro. Proc. Natl. Acad. Sci. USA, 83: 446-450, 1986.
9. Degliantoni, G., Murphy, M., Kobayashi, M., Francis, M.K., Perussia, B., and Trinchieri, G. Natural killer (NK) cell-derived hematopoietic colony-inhibiting activity and NK cytotoxic factor. Relationship with tumor necrosis factor and synergism with immune interferon. J. Exp. Med., 162: 1512-1530, 1985.
10. Pennica, D., Nedwin, G.E., Hayflick, J.S., Seeburg, P.H., Derynck, R., Palladino, M.A., Kohr, W.J., Aggarwal, B.B., and Goeddel, D.V. Human tumor necrosis factor: Precursor structure, expression and homology to lymphotoxin. Nature (Lond.), 312: 724-729, 1985.
11. Marmenout, A., Fransen, L., Tavernier, J., Van der Heyden, J., Tizard, R., Kawashima, E., Shaw, A., Johnson, M-J., Semon, D., Muller, R., Ruysschaert, M-R., Van Vliet, A., and Fiers, W. Molecular cloning and expression of human tumor necrosis factor and comparison with mouse tumor necrosis factor. Eur. J. Biochem., 152: 515-522, 1985.
12. Fransen, L., Muller, R., Marmenout, A., Tavernier, J., Van der Heyden, J., Kawashima, E., Chollet, A., Tizard, R., Van Heuverswyn, H., Van Vliet, A., Ruysschaert, M-R., and Fiers, W. Molecular cloning of mouse tumor necrosis factor cDNA and its eukaryotic expression. Nucleic Acids Res., 13: 4417-4429, 1985.
13. Balkwill, F.R., Goldstein, L., and Stebbing, N. Differential action of six human interferons against two human carcinomas growing in nude mice. Int. J. Cancer, 35: 613-617, 1985.
14. Haranaka, K., Satomi, N., and Sakurai, A. Antitumor activity of murine tumor necrosis factor (TNF) against transplanted murine tumors and heterotransplanted human tumors in nude mice. Int. J. Cancer, 34: 263-267, 1984.