Ketamine protects cultured neocortical neurons from hypoxic injury

Brain Research

Volumn 380, Issue 1, 1986, Pages 186-190

  Weiss, John ^a   Goldberg, Mark P ^a   Choi, Dennis W ^a  

^a STANFORD UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

cell culture; cell death; cyanide; glutamate; hypoxia; ketamine

Indexed keywords

GLUTAMIC ACID; KETAMINE; N METHYL DEXTRO ASPARTIC ACID; N METHYLASPARTIC ACID;

BRAIN CORTEX; BRAIN INJURY; CELL CULTURE; CELL DEATH; CENTRAL NERVOUS SYSTEM; DRUG EFFICACY; HYPOXIA; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMAL; ANOXIA; CELL SURVIVAL; CELLS, CULTURED; CEREBRAL CORTEX; KETAMINE; MICE; NEURONS; SODIUM CYANIDE; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TIME FACTORS;

EID: 0022458644     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-8993(86)91447-2     Document Type: Article

References (11)

1. The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N-methylaspartate
2. Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis
3. Glutamate neurotoxicity in cortical cell cultures is calcium-dependent
4. Excitatory amino acid neurotoxins: selectivity, specificity and mechanisms of action
5. Neurotransmitter amino acids in the CNS. II. Some change in amino acid levels in rat brain synaptosomes during and after in vitro anoxia and simulated ischemia
6. A re-examination of the reactions of cyanide with cytochrome c oxidase
7. Synaptic release of excitatory amino acid neurotransmitter mediates anoxic neuronal death
8. Blockade of N-methyl-d-aspartate receptors may protect against ischemic damage in the brain
9. An N-methylaspartate receptor-mediated synapse in rat cerebral cortex: a site of action of ketamine?
10. Glutamic acid and cerebral function
11. Hypoglycemia-induced neuronal damage prevented by an N-methyl-d-aspartate antagonist