Substance P and somatostatin modulate spinal cord excitability via physiologically different sensory pathways

Brain Research

Volumn 372, Issue 1, 1986, Pages 172-175

  Wiesenfeld Hallin, Z ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

C afferent; intrathecal; polymodal nociceptor; somatostatin; spinal cord; substance P; thermosensitive C afferent

Indexed keywords

SOMATOSTATIN; SUBSTANCE P;

ANIMAL EXPERIMENT; BIOLOGICAL MODEL; CENTRAL NERVOUS SYSTEM; DRUG COMPARISON; DRUG EFFICACY; DRUG MECHANISM; INTRATHECAL DRUG ADMINISTRATION; METHODOLOGY; NERVE CELL EXCITABILITY; NERVOUS SYSTEM; NOCICEPTION; NONHUMAN; PERIPHERAL NERVOUS SYSTEM; PRIORITY JOURNAL; RAT; SENSORY NERVE; SPINAL CORD; SPINAL REFLEX;

ACTION POTENTIALS; AFFERENT PATHWAYS; ANIMAL; ELECTRIC STIMULATION; HEAT; NEURONS, AFFERENT; PAIN; RATS; REFLEX; SOMATOSTATIN; SPINAL CORD; SUBSTANCE P; SUPPORT, NON-U.S. GOV'T;

EID: 0022456370     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-8993(86)91473-3     Document Type: Article

References (14)

1. Unmyelinated nociceptive units in two skin areas of the rat
2. Calcitonin gene-related peptide immunoreactivity in the spinal cord of man and of eight other species
3. Immunohistochemical evidence for separate populations of somatostatin-containing and substance P-containing primary afferent neurons in the rat
4. Peptidergic neurones
5. Cutaneous thermoreceptors in primates and subprimates
6. Evidence that substance P and somatostatin transmit separate information related to pain in the spinal dorsal horn
7. Primary afferent units from the hairy skin of the rat hind limb
8. Afferent C-fibres: physiological and biochemical correlations
9. Neurons that subserve the sensory-discriminative aspects of pain
10. Muscle but not cutaneous C-afferent input produces prolonged increases in the excitability of the flexion reflex in the rat
11. Intrathecal somatostatin modulates spinal sensory and reflex mechanisms: behavioral and electrophysiological studies in the rat
12. Immunoreactive calcitonin gene related peptide and substance P coexist in sensory neurons to the spinal cord and interact in spinal behavioral responses of the rat
13. Evidence for a central component of postinjury pain hypersensitivity
14. Substance P (SP) and calcitonin gene related peptide (CGRP) produce synergistic excitability changes in the spinal cord