Cytotoxicity, DNA Cross-Linking, and Single Strand Breaks Induced by Activated Cyclophosphamide and Acrolein in Human Leukemia Cells

Cancer Research

Volumn 46, Issue 10, 1986, Pages 5029-5034

  Crook, Tim R ^a,b   Souhami, Robert L ^b   McLean, Andre E M ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACROLEIN; CYCLOPHOSPHAMIDE; PHOSPHORAMIDE MUSTARD;

BLOOD AND HEMOPOIETIC SYSTEM; CHEMICAL MUTAGENESIS; CHRONIC MYELOID LEUKEMIA; CYTOTOXICITY; DNA CROSS LINKING; HEREDITY; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKEMIA CELL; LIVER; LIVER CELL; PRIORITY JOURNAL; RAT; SINGLE STRAND BREAK;

ACROLEIN; ALDEHYDES; ALKYLATION; ANIMAL; BIOTRANSFORMATION; CELL LINE; CELL SURVIVAL; CYCLOPHOSPHAMIDE; DNA; DNA DAMAGE; HUMAN; IN VITRO; LEUKEMIA, MYELOID; LIVER; MALE; PHOSPHORAMIDE MUSTARDS; RATS; RATS, INBRED STRAINS; SUPPORT, NON-U.S. GOV'T;

EID: 0022452407     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Souhami, R. L., Harper, P. G., Linch, D., Trask, C., Goldstone, A. H., Tobias, J., Spiro, S. G., Geddes, D. M., and Richards, J. D. M. High dose cyclophosphamide with autologous marrow transplantation as initial treatment of small cell carcinoma of the bronchus. Cancer Chemother. Pharmacol., 8:31-34,1982.
2. Low, J. E., Borch, R. F., and Sladek, N. E. Conversion of 4-hydroperoxycyclophosphamide and 4-hydroxycyclophosphamide to phosphoramide mustard and acrolein mediated by bifunctional catalysts. Cancer Res., 42: 830-837, 1982.
3. Hilton, J. Deoxyribonucleic acid cross–linking by 4-hydroperoxycyclophosphamide in cyclophosphamide-sensitive and cyclophosphamide-resistant LI 210 cells. Biochem. Pharmacol., 33: 1867-1872, 1984.
4. Sladek, N. E., and Landkamer, G. J. Restoration of sensitivity to oxaza- phosphorines by inhibitors of aldehyde dehydrogenase activity in cultured oxazaphosphorine-resistant LI210 and cross–linking agent-resistant P388 cell lines. Cancer Res., 45: 1549-1555,1985.
5. Erickson, L. C., Ramonas, L. M., Zaharko, D. S., and Kohn, K. W. Cytotoxicity and DNA cross–linking activity of 4-sulphidocyclophosphamide derivatives in vitro. Cancer Res., 40:4216-4220,1980.
6. Wrabtz, E., Peter, G., and Hohorst, H.-J. Does acrolein contribute to the cytotoxicity of cyclophosphamide? J. Cancer Res. Clin. Oncol., 98:119-126, 1980.
7. Devalia, J. L., Ogilvie, R. C., and McLean, A. E. M. Dissociation of cell death from covalent binding of paracetamol by flavones in a hepatocyte system. Biochem. Pharmacol., 31:3745-3749,1982.
8. Friedman, O. M., and Bolger, E. Colorimetric estimation of nitrogen mustards in aqueous media. Anal. Chem., 33:906-910, 1961.
9. Acosta, D., and Mitchell, D. B. Metabolic activation and cytotoxicity of cyclophosphamide in primary cultures of postnatal rat hepatocytes. Biochem. Pharmacol., 30:3225-3230, 1981.
10. Kohn, K. W., Ewig, R. A. G., Erickson, L. C., and Zwelling, L. A. Measurement of strand breaks and cross–links in DNA by alkaline elution. In: E. Friedberg and P. Hanawalt (eds.), DNA Repair A Laboratory Manual of Research Procedures, pp. 379-391. New York: Marcel Dekker, 1980.
11. Bates, D. J., Foster, A. B., and Jarman, M. The metabolism of cyclophosphamide by isolated rat hepatocytes. Biochem. Pharmacol., 30: 3055-3063, 1981.
12. Alley, M. C., Powis, G., Appel, P. L., Kooistra, K. L., and Lieber, M. M. Activation and inactivation of cancer chemotherapeutic agents by rat hepatocyte cocultures with human tumor cell lines. Cancer Res., 44: 549-556, 1984.
13. Wiebken, P., Sieg, M. S., Nelson, R. E., Hines, R. N. and Prough, R. A. Inhibition of metabolism mediated cytotoxicity by 1,1-disubstituted hydrazines in mouse mastocytoma (Line P815) cells. Biochem. Pharmacol., 31: 2921-2928,1982.
14. Brock, N., Gross, R., Hohorst, H.-J., Klein, H. O., and Schneider, B. Activation of cyclophosphamide in man and animals. Cancer (Phila.), 27: 1512-1529, 1971.
15. Bagley, C. M., Jr., Bostick, F. W., and DeVita, V. T., Jr. Clinical pharmacology of cyclophosphamide. Cancer Res., 33:226-233, 1973.
16. Friedman, O. M., Myles, A., and Colvin, M. Cyclophosphamide and related phosphoramide mustards. Current status and future prospects. Adv. Cancer Chemother., 1:143-204,1986.
17. Powers, J. F., and Sladek, N. E. Cytotoxic activity relative to 4-hydroxycyclophosphamide and phosphoramide mustard concentrations in the plasma of cyclophosphamide-treated rats. Cancer Res., 43:1101-1106, 1983.
18. Colvin, M., Brundrett, R. B., Kan, M.-N.N., Jardine, I., and Fenselau, C. Alkylating properties of phosphoramide mustard. Cancer Res., 36: 1121-1126, 1976.
19. Draeger, U., Peter, G., and Hohorst, H.-J. Deactivation of cyclophosphamide(NSC-26271) metabolites by sulphydryl compounds. Cancer Treat. Rep., 355-359, 1976.
20. Hohorst, H.-J., Draeger, U., Peter, G., and Voelcker, G. The problem of oncostatic specificity of cyclophosphamide (NSC-26271): Studies on reactions that control the alkylating and cytotoxic activity. Cancer Treat. Rep., 60:309-315, 1976.
21. Ross, W. E., Ewig, R. A. G., and Kohn, K. W. Difference between melphalan and nitrogen mustard in the formation and removal of DNA cross–links. Cancer Res., 38:1502-1506, 1978.
22. Zwelling, L. A., Anderson, T., and Kohn, K. W. DNA-protein and DNA interstrand cross–linking by cis- and frans-platinum(II)diammine dichloride in LI 210 mouse leukemia cells and relation to cytotoxicity. Cancer Res., 39: 365-369, 1979.
23. Mehta, J. R., Przybylski, M., and Ludlum, D. B. Alkylation of guanosine and deoxyguanosine by phosphoramide mustard. Cancer Res., 40: 4183-4186, 1980.
24. Ohno, Y., and Ormstad, K. Formation, toxicity, and inactivation of acrolein during biotransformation of cyclophosphamide as studied in freshly isolated cells from rat liver and kidney. Arch. Toxicol., 57:99-103, 1985.
25. Connors, T. A., Cox, P. J., Farmer, P. B., Foster, A. B., and Jarman, M. Some studies of the active intermediates formed in the microsomal metabolism of cyclophosphamide and isophosphamide. Biochem. Pharmacol., 23: 115-129,1974.
26. Crook, T. R., Soukami, R. L., Whyman, G. D., and McLean, A. E. M. Glutathione depletion as a determinant of sensitivity of human leukemia cells to cyclophosphamide. Cancer Res., 46:5035-5038, 1986.