Neuroendocrine effects of m-chlorophenylpiperazine, a serotonin agonist, in humans

Journal of Clinical Endocrinology and Metabolism

Volumn 61, Issue 6, 1985, Pages 1179-1184

  Mueller, Edward A ^a   Murphy, Dennis L ^a   Sunderland, Trey ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

(3 CHLOROPHENYL)PIPERAZINE; 5 HYDROXYTRYPTOPHAN; METERGOLINE; PLACEBO; SEROTONIN AGONIST; TRAZODONE;

ADVERSE DRUG REACTION; BLOOD PRESSURE; BODY TEMPERATURE; CARDIOVASCULAR SYSTEM; CENTRAL NERVOUS SYSTEM; CLINICAL ARTICLE; DOSE TIME EFFECT RELATION; DRUG COMPARISON; DRUG EFFICACY; DRUG SENSITIVITY; ENDOCRINE SYSTEM; HUMAN; HYDROCORTISONE BLOOD LEVEL; METHODOLOGY; MOOD; NERVOUS SYSTEM; NEUROENDOCRINE SYSTEM; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PROLACTIN BLOOD LEVEL;

ADULT; AGED; BEHAVIOR; BLOOD PRESSURE; BODY TEMPERATURE; FEMALE; HUMAN; HYDROCORTISONE; MALE; MIDDLE AGE; NEUROSECRETORY SYSTEMS; PIPERAZINES; PROLACTIN; PULSE; RECEPTORS, SEROTONIN;

EID: 0022411912     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jcem-61-6-1179     Document Type: Article

References (35)

1. Shopsin B, Friedman E, Gershon S 1976 Parachlorophenylalanine reversal of tranylcypromine effects in depressed patients. Arch Gen Psychiatry 33:811
2. Puhringer W, Wirz-Justice A, Graw P, Lacoste V, Gastpar M 1976 Intravenous 1-5 hydroxytryptophan in normal subjects: an interdisciplinary precursor loading study. Implications of reproducible mood elevation. Pharmacopsychiatry 9:260
3. Laakmann G, Wittmann M, Gugath M, Mueller OA, Treusch J, Wahlster U, Stalla GK 1984 Effects of psychotropic drugs (desi-pramine, chlorimipramine, sulpiride and diazepam) On the human HPA axis. Psychopharmacology 84:66
4. Charney DS, Heninger GR, Reinhard JF, Steinberg DE, Hafstead KM 1982 The effects of intravenous 1-tryptophan on prolactin and growth hormone and mood in healthy subjects. Psychopharmacology 77:217
5. Mashchak CA, Kletzky O, Spencer C, Artal R 1983 Transient effect of 1-5-hydroxytryptophan on pituitary function in men and women. J Clin Endocrinol Metab 56:170
6. Meitzer HY, Uberkoman-Wiita B, Roberson A, Tricoü BJ, Lowy M 1983 Enhanced serum cortisol response to 5-hydroxytryptophan in depression and mania. Life Sci 33:2541
7. Quattrone A, Tedeschi G, Aguglia F, Scopacasa F, Direnzo GF, Annunziato L 1983 Prolactin secretion in man: a useful tool to evaluate the activity of drugs on central 5-hydroxytryptaminergic neurons, studies with fenfluramine. Br J Clin Pharmacol 16:471
8. Siever LJ, Murphy DL, Slater S, de la Vega E, Lipper S 1984 Plasma prolactin changes following fenfluramine in depressed patients compared to controls: an evaluation of central serotonergic responsivity in depression. Life Sci 34:1029
9. Mueller EA, Siever L, Murphy DL 1985 Neuroendocrine responses to serotonin agonists as possible markers of the functional state of serotonergic neurotransmission in psychiatric disorders. In: Beckman H, Riederer P (eds) Pathochemical Markers of the Psychoses. Springer-Verlag, Berlin, p 110
10. Meitzer H, Wiita B, Tricou BJ, Simonovic M, Fang V, Manov G 1982 Effects of serotonin precursors and serotonin agonists on plasma hormone levels. In: Ho BT (ed) Serotonin in Biological Psychiatry. Raven Press, New York, p 117
11. Samanin R, Mennini T, Ferraris A 1979 M-Chlorophenylpipera-zine: a central serotonin agonist causing powerful anorexia in rats. Naunyn Schmiedebergs Arch Pharmacol 308:159
12. 3H]-serotonin binding to rat brain membranes in vitro by 1-phenylpiperazines. Biochem Pharmacol 29:833
13. Caccia S, Fong MH, Garattini, Zanini MG 1982 Plasma concentrations of trazodone and l-(3-chlorophenyl)piperazine in man after a single oral dose of trazodone. J Pharm Pharmacol 34:605
14. Caccia S, Ballabio M, Samanin R 1981 (-)-m-Chlorophenylpiper-azine, a central 5-hydroxytryptamine agonist, is a metabolite of trazodone. J Pharm Pharmacol 33:477
15. Fuller RW, Snoddy HD, Mason NR, Owen JE 1981 Disposition and pharmacological effects of m-chlorophenylpiperazine in rats. Neuropharmacology 20:155
16. Invernizzi R, Cotecchia S, DeBlasi A, Mennini T, Pataccini R, Samanin R 1981 Effects of m-chlorophenylpiperazine on receptor binding and brain metabolism of monoamines in rats. Neurochem Int 3:239
17. Maj J, Lewandowska A 1980 Central serotoninmimetic action of phenylpiperazines. Pol J Pharmacol Pharm 32:495
18. Rokosz-Pelc A, Antkiewics-Michaluk L, Vetulani J 1980 5-hydrox-ytryptamine-like properties of m-chlorophenylpiperazine: comparison with quipazine. J Pharm Pharmacol 32:220
19. Aloi JA, Insel TR, Mueller EA, Murphy DL 1984 Neuroendocrine and behavioral effects of m-chlorophenylpiperazine administration in rhesus monkeys. Life Sci 34:1325
20. Quattrone A, Schettini G, Anunziato L, DeRenzo G 1981 Pharmacological evidence of super-sensitivity of central serotonergic receptors involved in control of prolactin secretion. Eur J Pharmacol 76:9
21. 3H-serotonin binding and functional studies in the rat. Brain Res 189:449
22. Cohen RM, Aulakh CS, Murphy DL 1983 Long term clorgyline treatment antagonizes the eating and motor function responses to m-chlorophenylpiperazine. Eur J Pharmacol 94:175
23. Van Kammen DP, Murphy DL 1975 Attenuation of the euphoriant and activating effects of d- and /-amphetamine by lithium carbonate treatment. Psychopharmacologia 44:215
24. Winer BJ 1971 Statistical Principles in Experimental Design, ed 2. McGraw-Hill, New York
25. Siegel S 1956 Nonparametric Statistics for the Behavioral Sciences. McGraw Hill, New York, p i95
26. Bailey BJR 1977 Tables of the Bonferroni t Statistic. J Am Stat Assoc 72:469
27. Parati EA, Zanardi P, Cochi D, Caraceni T, Muller EE 1980 Neuroendocrine effects of quipazine in man in health state or with neurological disorders. J Neurol Transm 47:273
28. Fuller RW 1981 Serotonergic stimulation of pituitary adrenocorical function in rats. Neuroendocrinology 32:118
29. Spinedi E, Negro-Vilar A 1983 Serotonin and ACTH release: direct effects at the anterior pituitary level and potentiation of arginine-vasopressin-induced ACTH release. Endocrinology 112:1217
30. Fuller RW, Snoddy HD 1979 The effects of metergoline and other serotonin receptor antagonists on serum corticosterone in rats. Endocrinology 105:923
31. Myers RD, Waller MB 1978 Thermoregulation and Serotonin. In: Serotonin in Health and Disease. Spectrum, New York, vol 2:1
32. Murphy DL, Campbell IC, Costa JL 1978 The brain serotonin system in the affective disorders. Prog Neuropsychopharmacol 2:1
33. Siever LJ, Guttmacher LM, Murphy DL 1984 Serotonergic receptors: Evaluation of their possible role in the affective disorders. In: Post RM, Ballenger JC (eds) Neurobiology of Mood Disorders. Williams & Wilkins, Baltimore, p 587
34. Van Praag HM 1983 Depression, suicide and serotonin metabolism in the brain. In: Post RM, Ballenger JC (eds) Neurobiology of Mood Disorders. Williams & Wilkins, Baltimore, p 601
35. Sepinwall J 1983 Behavioral studies related to the neurochemical mechanisms of action of anxiolytics. In: Malick JB, Enna SJ, Yamamura HI (eds) Anxiolytics: Neurochemical, Behavioral and Clinical Perspectives. Raven Press, New York, p 147