Type A Viral Hepatitis: New Developments in an Old Disease

New England Journal of Medicine

Volumn 313, Issue 17, 1985, Pages 1059-1067

  Lemon, Stanley M ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN; LIVE VACCINE; VACCINE;

CELL CULTURE; DIAGNOSIS; EPIDEMIOLOGY; ETIOLOGY; HEPATITIS A; HEPATITIS A VIRUS; HUMAN; IMMUNE RESPONSE; IMMUNIZATION; IN VITRO STUDY; LIVER; PATHOGENESIS; PREVENTION; PRIORITY JOURNAL; SHORT SURVEY; VIROLOGY; VIRUS CHARACTERIZATION;

EID: 0022405095     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM198510243131706     Document Type: Review

References (124)

1. Vyas GN, Dienstag JL, Hoofnagle JH, eds. Viral hepatitis and liver disease. Orlando: Grune & Stratton, 1984.
2. Feinstone SM, Kapikian AZ, Purcell RH. Hepatitis A: detection by immune electron microscopy of a viruslike antigen associated with acute illness. Science 1973; 182: 1026–8.
3. Provost PJ, Hilleman MR. Propagation of human hepatitis A virus in cell culture in vitro. Proc Soc Exp Biol Med 1979; 160: 213–21.
4. Ticehurst JR, Racaniello VR, Baroudy BM, Baltimore D, Purcell RH, Feinstone SM. Molecular cloning and characterization of hepatitis A virus cDNA. Proc Natl Acad Sci USA 1983; 80: 5885–9.
5. Siegl G. Structure and biology of hepatitis A virus. In: Szmuness W, Alter HJ, Maynard JE, eds. Viral hepatitis. Philadelphia: Franklin Institute Press, 1982:13–20.
6. Siegl G, Frösner GG, Gauss-Müller V, Tratschin J-D, Deinhardt F. The physicochemical properties of infectious hepatitis A virions. J Gen Virol 1981; 57: 331–41.
7. Lemon SM, Jansen RW, Newbold JE. Infectious hepatitis A virions produced in cell culture consist of three distinct types with different buoyant densities in CsCl. J Virol 1985; 54: 78–85.
8. Coulepis AG, Locamini SA, Westaway EG, Tannock GA, Gust ID. Biophysical and biochemical characterization of hepatitis A virus. Intervirology 1982; 18: 107–27.
9. Baroudy BM, Ticehurst JR, Miele TA, Maizel JV, Purcell RH, Feinstone SM. Sequence analysis of hepatitis A virus cDNA coding for capsid proteins and RNA polymerase. Proc Natl Acad Sci USA 1985; 82: 2143–7.
10. Najarian R, Caput D, Gee W, et al. Primary structure and gene organization of human hepatitis A virus. Proc Natl Acad Sci USA 1985; 82: 2627–31.
11. Bradley DW, Fields HA, McCaustland KA, Cook EH, Gravelle CR, Maynard JE. Biochemical and biophysical characterization of light and heavy density hepatitis A virus particles: evidence HAV is an RNA virus. J Med Virol 1978; 2: 175–87.
12. Siegl G, Frösner GG. Characterization and classification of virus particles associated with hepatitis A. II. Type and configuration of nucleic acid. J Virol 1978; 26: 48–53.
13. Coulepis AG, Tannock GA, Locarnini SA, Gust ID. Evidence that the genome of hepatitis A virus consists of single-stranded RNA. J Virol 1981; 3: 473–7.
14. von der Helm K, Winnacker EL, Dienhardt F, et al. Cloning of hepatitis A virus genome. J Virol Methods 1981; 3: 37–43.
15. Linemeyer DL, Menke JG, Martin-Gallardo A, Hughes JV, Young A, Mitra SW. Molecular cloning and partial sequencing of hepatitis A viral. J Virol 1985; 54: 247–55.
16. Melnick JL. Classification of hepatitis A virus as enterovirus type 72 and of hepatitis B virus as hepadnavirus type 1. Intervirology 1982; 18: 105–6.
17. Siegl G. The biochemistry of hepatitis A virus. In: Gerety RH, ed. The hepatitis A virus. New York: Academic Press, 1984:81–100.
18. Siegl G, Weitz M, Kronauer G. Stability of hepatitis A virus. Intervirology 1984; 22: 218–26.
19. Siegl G, Eggers HJ. Failure of guanidine and 2-(α-hydroxybenzyl)benzimidazole to inhibit replication of hepatitis A virus in vitro. J Gen Virol 1982; 61: 111–4.
20. Emini EA, Berger J, Hughes JV, Mitra SW, Linemeyer DL. Priming of an anti-hepatitis A virus antibody response by poliovirus-specific synthetic peptides: localization of potential antigenic sites of hepatitis A virus neutralization. In: Lerner RA, Chanock RM, Brown F, eds. Vaccines 85: molecular and chemical basis of resistance to parasitic, bacterial and viral diseases. Cold Spring Harbor, N.Y.: Cold Spring Harbor Laboratory, 1985:217–20.
21. Frösner GG, Deinhardt F, Scheid R, et al. Propagation of human hepatitis A virus in a hepatoma cell line. Infection 1979; 7: 303–5.
22. Daemer RJ, Feinstone SM, Gust ID, Purcell RH. Propagation of human hepatitis A virus in African green monkey kidney cell culture: primary isolation and serial passage. Infect Immun 1981; 32: 388–93.
23. Binn LN, Lemon SM, Marchwicki RH, Redfield RR, Gates NL, Bancroft WH. Primary isolation and serial passage of hepatitis A virus strains in primate cell cultures. J Clin Microbiol 1984; 20: 28–33.
24. Lemon SM, Binn LN, Marchwicki RH. Radioimmunofocus assay for quantitation of hepatitis A virus in cell cultures. J Clin Microbiol 1983; 17: 834–9.
25. Provost PJ, Banker FS, Giesa PA, McAleer WJ, Buynak EB, Hilleman MR. Progress toward a live, attenuated human hepatitis A vaccine. Proc Soc Exp Biol Med 1982; 170: 8–14.
26. Provost PJ, Ittensohn OL, Villarejos VM, Hilleman MR. A specific complement-fixation test for human hepatitis A employing CR326 virus antigen: diagnosis and epidemiology. Proc Soc Exp Biol Med 1975; 148: 962–9.
27. Miller WJ, Provost PJ, McAleer WJ, Ittensohn OL, Villarejos VM, Hilleman MR. Specific immune adherence assay for human hepatitis A antibody. Application to diagnostic and epidemiologic investigations. Proc Soc Exp Biol Med 1975; 149: 254–61.
28. Hollinger FB, Bradley DW, Maynard JE, Dreesman GR, Melnick JL. Detection of hepatitis A viral antigen by radioimmunoassay. J Immunol 1975; 115: 1464–6.
29. Purcell RH, Wong DC, Moritsugu Y, Dienstag JL, Routenberg J, Boggs JD. A microtiter solid-phase radioimmunoassay for hepatitis A antigen and antibody. J Immunol 1976; 116: 349–56.
30. Mathiesen LR, Feinstone SM, Wong DC, Skinhoej P, Purcell RH. Enzyme-linked immunosorbent assay for detection of hepatitis A antigen in stool and antibody to hepatitis A antigen in sera: comparison with solid-phase radioimmunoassay, immune electron microscopy, and immune adherence hemagglutination assay. J Clin Microbiol 1978; 7: 184–93.
31. Locarnini SA, Garland SM, Lehmann NI, Pringle RC, Gust ID. Solid-phase enzyme-linked immunosorbent assay for detection of hepatitis A virus. J Clin Microbiol 1978; 8: 277–82.
32. Lemon SM, Binn LN. Serum neutralizing antibody response to hepatitis A virus. J Infect Dis 1983; 148: 1033–9.
33. Hughes JV, Stanton LW, Tomassini JE, Long WJ, Scolnick EM. Neutralizing monoclonal antibodies to hepatitis A virus: partial localization of a neutralizing antigenic site. J Virol 1984; 52: 465–73.
34. Lemon SM, LeDuc JW, Binn LN, Escajadillo A, Ishak KG. Transmission of hepatitis A virus among recently captured Panamanian owl monkeys. J Med Virol 1982; 10: 25–36.
35. Lemon SM, Binn LN. Antigenic relatedness of two strains of hepatitis A virus determined by cross-neutralization. Infect Immun 1983; 42: 418–20.
36. Weitz M, Siegl G. Comparison of HAV strains isolated in far apart geographical regions. In:1, p. 704.
37. Khuroo MS. Study of an epidemic of non-A, non-B hepatitis: possibility of another human hepatitis virus distinct from post-transfusion non-A, non-B type. Am J Med 1980; 68: 818–24.
38. Wong DC, Purcell RH, Sreenivasan MA, Prasad SR, Pavri KM. Epidemic and endemic hepatitis in India: evidence for a non-A, non-B hepatitis virus aetiology. Lancet 1980; 2: 876–8.
39. Balayan MS, Andjaparidze AG, Savinskaya SS, et al. Evidence for a virus in non-A, non-B hepatitis transmitted via the fecal-oral route. Intervirology 1983; 20: 23–31.
40. Sreenivasan MA, Arankalle VA, Sehgal A, Pavri KM. Non-A, non-B epidemic hepatitis: visualization of virus-like particles in the stool by immune electron microscopy. J Gen Virol 1984; 65: 1005–7.
41. Kane MA, Bradley DW, Shrestha SM, et al. Epidemic non-A, non-B hepatitis in Nepal: recovery of a possible etiologic agent and transmission studies in marmosets. JAMA 1984; 252: 3140–5.
42. Neefe JR, Gellis SS, Stokes J Jr. Homologous serum hepatitis and infectious (epidemic) hepatitis: studies in volunteers bearing on immunological and other characteristics of the etiological agents. Am J Med 1946; 1: 3–22.
43. Krugman S, Giles JP, Hammond J. Infectious hepatitis: evidence for two distinctive clinical, epidemiological, and immunological types of infection. JAMA 1967; 200: 365–73.
44. Boggs JD, Melnick JL, Conrad ME, Felsher BF. Viral hepatitis: clinical and tissue culture studies. JAMA 1970; 214: 1041–6.
45. Deinhardt F, Peterson D, Cross G, Wolfe L, Holmes AW. Hepatitis in marmosets. Am J Med Sci 1975; 270: 73–80.
46. Dienstag JL, Feinstone SM, Purcell RH, et al. Experimental infection of chimpanzees with hepatitis A virus. J Infect Dis 1975; 132: 532–45.
47. LeDuc JW, Lemon SM, Keenan CM, Graham RR, Marchwicki RH, Binn LN. Experimental infection of the new world owl monkey (Aotus trivirgatus) with hepatitis A virus. Infect Immun 1983; 40: 766–72.
48. Lemon SM. Animal models in hepatitis research. In: Csomos G, Thaler H, eds. Clinical hepatology. Berlin: Springer-Verlag, 1983:244–60.
49. Mathiesen LR, Feinstone SM, Purcell RH, Wagner JA. Detection of hepatitis A antigen by immunofluorescence. Infect Immun 1977; 18: 524–30.
50. Mathiesen LR, Drucker J, Lorenz D, Wagner J, Gerety RJ, Purcell RH. Localization of hepatitis A antigen in marmoset organs during acute infection with hepatitis A virus. J Infect Dis 1978; 138: 369–77.
51. Provost PJ, Wolanski BS, Miller WJ, Ittensohn OL, McAleer WJ, Hilleman MR. Biophysical and biochemical properties of CR326 human hepatitis A virus. Am J Med Sci 1975; 270: 87–92.
52. Schulman AN, Dienstag JL, Jackson DR, et al. Hepatitis A antigen particles in liver, bile, and stool of chimpanzees. J Infect Dis 1976; 134: 80–4.
53. Shimizu YK, Shikata T, Beninger PR, et al. Detection of hepatitis A antigen in human liver. Infect Immun 1982; 36: 320–4.
54. Purcell RH, Feinstone SM, Ticehurst JR, Daemer RJ, Baroudy BM. Hepatitis A virus. In:1, pp. 9–22.
55. Mathiesen LR, Møller AM, Purcell RH, London WT, Feinstone SM. Hepatitis A virus in the liver and intestine of marmosets after oral inoculation. Infect Immun 1980; 28: 45–48.
56. Krawczynski KK, Bradley DW, Murphy BL, et al. Pathogenetic aspects of hepatitis A virus infection in enterally inoculated marmosets. Am J Clin Pathol 1981; 76: 698–706.
57. Wollheim FA. Immunoglobulins in the course of viral hepatitis and in cholestatic and obstructive jaundice. Acta Med Scand 1968; 183: 473–9.
58. Lemon SM, Brown CD, Brooks DS, Simms TE, Bancroft WH. Specific immunoglobulin M response to hepatitis A virus determined by solid-phase radioimmunoassay. Infect Immun 1980; 28: 927–36.
59. Miller HFA, Legler K. Thomssen R. Increase in immunoglobulin M antibodies against gut bacteria during acute hepatitis A. Infect Immun 1983; 40: 542–7.
60. Rakela J, Stevenson D, Edwards VM, Gordon I, Mosley JW. Antibodies to hepatitis A virus: patterns by two procedures. J Clin Microbiol 1977; 5: 110–1.
61. Decker RH, Overby LR, Ling C-M, Frösner G, Deinhardt F, Boggs J. Serologic studies of transmission of hepatitis A in humans. J Infect Dis 1979; 139: 74–82.
62. Locarnini SA, Ferris AA, Lehmann NI, Gust ID. The antibody response following hepatitis A infection. Intervirology 1977 8: 309–18.
63. Duermeyer W, Wielaard F, van der Veen J. A new principle for the detection of specific IgM antibodies applied in an ELISA for hepatitis A. J Med Virol 1979; 4: 25–32.
64. Dienstag JL, Feinstone SM, Kapikian AZ, Purcell RH, Boggs JD, Conrad ME. Faecal shedding of hepatitis-A antigen. Lancet 1975; 1: 765–7.
65. Rakela J. Mosley JW. Fecal excretion of hepatitis A in humans. J Infect Dis 1977; 135: 933–8.
66. Coulepis AG, Locarnini SA, Lehmann NI, Gust ID. Detection of hepatitis A virus in the feces of patients with naturally acquired infections. J Infect Dis 1980; 141: 151–6.
67. Skinhøj P, Mathiesen LR, Kryger P, Møller AM, et al. Faecal excretion of hepatitis A virus in patients with symptomatic hepatitis A infection. Scand J Gastroenterol 1981; 16: 1057–9.
68. Flehmig B, Zahn J, Vallbracht A. Levels of neutralizing and binding antibodies to hepatitis-A virus after onset of icterus: a comparison. J Infect Dis 1984; 150: 461.
69. Provost PJ, Wolanski BS, Miller WJ, Ittensohn OL, McAleer WJ, Hilleman MR. Physical, chemical and morphologic dimensions of human hepatitis A virus strain CR326. Proc Soc Exp Biol Med 1975; 148: 32–9.
70. Lemon SM, Binn LN. Incomplete neutralization of hepatitis A virus in vitro due to lipid-associated virions. J Gen Virol (in press).
71. Ajdukiewicz A, Mosley JW. Hepatitis-A-virus exposure in the Gambia. Lancet 1979; 2: 966.
72. Villarejos VM, Serra C J, Anderson-Visona K, Mosley JW. Hepatitis A virus infection in households. Am J Epidemiol 1982; 115: 577–86.
73. Stapleton JT, Jansen R, Lemon SM. Serum neutralizing antibody to hepatitis A virus in immune serum globulin and in the sera of human recipients of immune serum globulin. Gastroenterology 1985; 89: 637–42.
74. Locarnini SA, Coulepis AG, Kaldor J, Gust ID. Coproantibodies in hepatitis A: detection by enzyme-linked immunosorbent assay and immune electron microscopy. J Clin Microbiol 1980; 11: 710–6.
75. Yoshizawa H, Itoh Y, Iwakiri S, et al. Diagnosis of type A hepatitis by fecal IgA antibody against hepatitis A antigen. Gastroenterology 1980; 78: 114–8.
76. Dienstag JL, Popper H, Purcell RH. The pathology of viral hepatitis types A and B in chimpanzees. Am J Pathol 1976; 85: 131–44.
77. Teixeira MR Jr, Weller IVD, Murray A, et al. The pathology of hepatitis A in man. Liver 1982; 2: 53–60.
78. Keenan CM, Lemon SM, LeDuc JW, McNamee GA, Binn LN. Pathology of hepatitis A infection in the owl monkey (Aotus trivirgatus). Am J Pathol 1984; 115: 1–8.
79. Kurane I, Binn LN, Bancroft W, Ennis FA. Human lymphocyte response to hepatitis A virus infected cells: interferon production and lysis of infected cells. J Immunol (in press).
80. Hadler SC, Webster HM, Erben JJ, Swanson JE, Maynard JE. Hepatitis A in day-care centers: a community-wide assessment. N Engl J Med 1980; 302: 1222–7.
81. Benenson MW, Takafuji ET, Bancroft WH, Lemon SM, Callahan MC, Leach DA. A military community outbreak of hepatitis type A related to transmission in a child care facility. Am J Epidemiol 1980; 112: 471–81.
82. Lednar WM, Lemon SM, Kirkpatrick JW, Redfield RR, Fields ML, Kelley PW. Frequency of illness associated with hepatitis A virus infection in adults. Am J Epidemiol 1985; 122: 226–33.
83. Bromberg K, Newhall DN, Peter G. Hepatitis A and meningoencephalitis. JAMA 1982; 247: 815.
84. Hammond GW, MacDougall BK, Plummer F, Sekla LH. Encephalitis during the prodromal stage of acute hepatitis A. Can Med Assoc J 1982; 126: 269–70.
85. Rakela J, Redeker AG, Edwards VM, Decker R, Overby LR, Mosley JW. Hepatitis A virus infection in fulminant hepatitis and chronic active hepatitis. Gastroenterology 1978; 74: 879–82.
86. Mathiesen LR, Skinoj P, Nielsen JO, Purcell RH, Wong D, Ranek L. Hepatitis type A, B and non-A, non-B in fulminant hepatitis. Gut 1980; 21: 72–77.
87. Gust ID. The epidemiology of viral hepatitis. In:1, pp. 415–21.
88. Dienstag JL, Szmuness W, Stevens CE, Purcell RH. Hepatitis A virus infection: new insights from seroepidemiologic studies. J Infect Dis 1978; 137: 328–40.
89. Kao HW, Ashcavai M, Redeker AG. The persistence of hepatitis A IgM antibody after acute clinical hepatitis A. Hepatology 1984; 4: 933–6.
90. Gordon SC, Reddy KR, Schiff L, Schiff ER. Prolonged intrahepatic cholestasis secondary to acute hepatitis A. Ann Intern Med 1984; 101: 635–7.
91. Hepatitis Surveillance Report No 49. Atlanta: Centers for Disease Control, January 1985.
92. Francis DP, Hadler SC, Prendergast TJ, et al. Occurrence of hepatitis A, B and non-A/non-B in the United States: CDC Sentinel County Hepatitis Study I. Am J Med 1984; 76: 69–74.
93. Hollinger FB, Khan NC, Oefinger PE, et al. Posttransfusion hepatitis type A. JAMA 1983; 250: 2313–7.
94. Hadler SC, Erben JJ, Matthews D, Starko K, Francis DP, Maynard JE. Effect of immunoglobulin on hepatitis A in day-care centers. JAMA 1983; 249: 48–53.
95. Corey L. Holmes KK. Sexual transmission of hepatitis A in homosexual men: incidence and mechanism. N Engl J Med 1980; 302: 435–8.
96. Christenson B, Broström C, Böttiger M, et al. An epidemic outbreak of hepatitis A among homosexual men in Stockholm: hepatitis A, a special hazard for the male homosexual subpopulation in Sweden. Am J Epidemiol 1982; 116: 599–607.
97. Szmuness W, Stevens CE, Zang EA, Harley EJ, Kellner A. A controlled clinical trial of the efficacy of the hepatitis B vaccine (Heptavax B): a final report. Hepatology 1981; 1: 377–85.
98. Szmuness W, Dienstag JL, Purcell RH, Harley EJ, Stevens CE, Wong DC. Distribution of antibody to hepatitis A antigen in urban adult populations. N Engl J Med 1976; 295: 755–9.
99. Frösner G, Willers H, Müller R, Schenzle D, Deinhardt F, Höpken W. Decrease in incidence of hepatitis A infections in Germany. Infection 1978; 6: 259–60.
100. Gust ID, Lehmann NI, Lucas CR. Relationship between prevalence of antibody to hepatitis A antigen and age: a cohort effect? J Infect Dis 1978; 138: 425–6.
101. Wong DC, Purcell RH, Rosen L. Prevalence of antibody to hepatitis A and hepatitis B viruses in selected populations of the South Pacific. Am J Epidemiol 1979; 110: 227–36.
102. Burke DS, Snitbahn R, Johnson DE, Scott RMCN. Age-specific prevalence of hepatitis A virus antibody in Thailand. Am J Epidemiol 1981; 113: 245–9.
103. Szmuness W, Dienstag JL, Purcell RH, et al. The prevalence of antibody to hepatitis A antigen in various parts of the world: a pilot study. Am J Epidemiol 1977; 106: 392–8.
104. Prince AM, Brotman B, Richardson L, White T, Pollock N, Riddle J. Incidence of hepatitis A virus (HAV) infection in rural Liberia. J Med Virol 1985; 15: 421–8.
105. Stokes J Jr, Neefe JR. The prevention and attenuation of infectious hepatitis by gamma globulin. JAMA 1945; 127: 144–5.
106. Gellis SS, Stokes J Jr, Brother GM, et al. The use of human immune serum globulin (gamma globulin) in infectious (epidemic) hepatitis in the Mediterranean theater of operations. JAMA 1945; 128: 1062–3.
107. Krugman S, Ward R, Giles JP, Jacobs AM. Infectious hepatitis: studies on the effect of gamma globulin and on the incidence of inapparent infection. JAMA 1960; 174: 823–30.
108. Mosley JW, Reisler DM, Brachott D, Roth D, Weiser J. Comparison of two lots of immune serum globulin for prophylaxis of infectious hepatitis. Am J Epidemiol 1968; 87: 539–50.
109. Stokes J Jr, Farquhar JA, Drake ME, Capps RB, Ward CS Jr, Kitts AW. Infectious hepatitis: length of protection by immune serum globulin (gamma globulin) during epidemics. JAMA 1951; 147: 714–9.
110. Immunization Practices Advisory Committee. Recommendations for protection against viral hepatitis. MMWR 1985; 34: 313–35.
111. Provost PJ, Hilleman MR. An inactivated hepatitis A virus vaccine prepared from infected marmoset liver. Proc Soc Exp Biol Med 1978; 159: 201–3.
112. Widell A, Hansson BG, Nordenfelt E. A microcarrier cell culture system for large scale production of hepatitis A virus. J Virol Methods 1984; 8: 63–71.
113. Ogra PL, Fishaut M, Gallagher MR. Viral vaccination via the mucosal routes. Rev Infect Dis 1980; 2: 352–69.
114. Provost PJ, Conti PA, Giesa PA, et al. Studies in chimpanzees of live, attenuated hepatitis A vaccine candidates. Proc Soc Exp Biol Med 1983; 172: 357–63.
115. Provost PJ, Buynak EB, McLean AA, Hilleman MR, Scolnick EM. Progress toward a live attenuated hepatitis A vaccine. In:1, pp. 467–75.
116. Hilleman MR. Whither immunization against viral infections? Ann Intern Med 1984; 101: 852–8.
117. Feinstone SM, Daemer RJ, Gust ID, Purcell RH. Live attenuated vaccine for hepatitis A. In: Papaevangelou G, Hennessen W, eds. Viral hepatitis: standardization in immunoprophylaxis of infections by hepatitis vaccines. Basel: S Karger, 1983:429–32.
118. Kleid DG, Yansura D, Small B, et al. Cloned viral protein vaccine for foot-and-mouth disease: responses in cattle and swine. Science 1981; 214: 1125–9.
119. Jameson BA, Bonin J, Murray MG, Wimmer E, Kew O. Peptide-induced neutralizing antibodies to poliovirus. In: Lerner RA, Chanock RM, Brown F, eds. Vaccines 85: molecular and chemical basis of resistance to parasitic, bacterial and viral diseases. Cold Spring Harbor, N.Y.: Cold Spring Harbor Laboratory, 1985:191–8.
120. Hughes JV, Bennett C, Stanton L, Linemeyer DL, Mitra SW. Hepatitis A virus structural proteins: sequencing and ability to induce virus-neutralizing antibody responses. In: Lerner RA, Chanock RM, Brown F, eds. Vaccines 85: molecular and chemical basis of resistance to parasitic, bacterial and viral diseases. Cold Spring Harbor, N.Y.: Cold Spring Harbor Laboratory, 1985:255–9.
121. Emini EA, Jameson BA, Lewis AJ, Larsen GR, Wimmer E. Poliovirus neutralization epitopes: analysis and localization with neutralizing monoclonal antibodies. J Virol 1982; 43: 997–1005.
122. Minor PD, Schild GC, Bootman J, et al. Location and primary structure of a major antigenic site for poliovirus neutralization. Nature 1983; 301: 674–9.
123. Emini EA, Ostapchuk P, Wimmer E. Bivalent attachment of antibody onto poliovirus leads to conformational alteration and neutralization. J Virol 1983; 48: 547–50.
124. Diamond DC, Jameson BA, Emini EA, Wimmer E. Antibody-resistant variants of poliovirus type 1. In: Lerner RA, Chanock RM, Brown F, eds. Vaccines 85: molecular and chemical basis of resistance to parasitic, bacterial and viral diseases. Cold Spring Harbor, N.Y.: Cold Spring Harbor Laboratory, 1985:241–7.