Synthesis of 7,8-acetylenic analogs of hexahydro leukotriene-E4 with agonist and antagonist activities: convenient stereoselective routes to E- and Z-enynes

Tetrahedron Letters

Volumn 26, Issue 52, 1985, Pages 6423-6426

  Saksena, Anil K ^a   Green, Michael J ^a   Mangiaracina, Pietro ^a   Wong, Jesse K ^a   Kreutner, William ^a   Gulbenkian, Arax R ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7 [3 (4 ACETYL 3 HYDROXY 2 PROPYLPHENOXY) 2 HYDROXYPROPOXY] 4 OXO 8 PROPYL 4H 1 BENZOPYRAN 2 CARBOXYLIC ACID; LEUKOTRIENE E4; LEUKOTRIENE E4 DERIVATIVE;

ANIMAL CELL; DRUG ANTAGONISM; DRUG COMPARISON; DRUG INHIBITION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; GUINEA PIG; NONHUMAN; PRELIMINARY COMMUNICATION; PRIORITY JOURNAL; RESPIRATORY SYSTEM; SMALL INTESTINE; STRUCTURE ACTIVITY RELATION;

EID: 0022397622     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(00)99017-8     Document Type: Article

References (30)

1. Synthesis and 5-lipoxygenase inhibitory activities of eicosanoid compounds
2. The preparation of octahydro leukotrienes C, D, and E via a stereoselective sulfenyllactonization reaction
3. Regio- and stereoselective synthesis of -1,3-enynes via coupling of nucleophiles with 1-[(alkynyl) dicobalt hexacarbonyl]allyl cations
4. An alkyne protecting group
5. Ouverture acide d'alcoolsαcyclopropaniquesα'acetyleniques complexes par le dicobalt-octacarbony le. Obtention stereoselective d'enynes conjugues E, precurseurs de dienes conjugues E, Z.
6. Total synthesis of 5-desoxyleukotriene D. A new and useful equivalent of the 4-formyl-, -1,3-butadienyl anion
7. Synthesis of macrocyclic and medium-ring dithia compounds using caesium thiolates
8. Reduction of .alpha.,.beta.-acetylenic ketones with B-3-pinanyl-9-borabicyclo[3.3.1]nonane. High asymmetric induction in aliphatic systems