Ketamine and phencyclidine cause a voltage-dependent block of responses to l-aspartic acid

Neuroscience Letters

Volumn 61, Issue 1-2, 1985, Pages 135-139

  Honey, C R ^a   Miljkovic, Z ^a   Macdonald, J F ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

cultured neuron; kainic acid; ketamine; l aspartic acid; phencyclidine; spinal cord

Indexed keywords

4 AMINOBUTYRIC ACID; ASPARTIC ACID; BICUCULLINE; KAINIC ACID; KETAMINE; N METHYLASPARTIC ACID; PHENCYCLIDINE; TETRODOTOXIN;

ANIMAL CELL; CELL CULTURE; CENTRAL NERVOUS SYSTEM; CYTOLOGY; DRUG ADMINISTRATION; DRUG COMPARISON; DRUG MECHANISM; DRUG MONITORING; IN VITRO STUDY; MOUSE; NERVE CELL MEMBRANE POTENTIAL; NERVE FIBER MEMBRANE CONDUCTANCE; NERVOUS SYSTEM; NONHUMAN; PRELIMINARY COMMUNICATION; PRIORITY JOURNAL; SPINAL CORD; SPINAL CORD NERVE CELL;

ANIMAL; ASPARTIC ACID; CELL MEMBRANE; CELLS, CULTURED; COMPARATIVE STUDY; ELECTRIC CONDUCTIVITY; ION CHANNELS; KETAMINE; MAGNESIUM; MEMBRANE POTENTIALS; MICE; PHENCYCLIDINE; SPINAL CORD; SUPPORT, NON-U.S. GOV'T;

EID: 0022393628     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3940(85)90414-8     Document Type: Article

References (11)

1. The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurons by N-methyl-aspartate
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4. dl-Quisqualic and l-aspartic acids activate separate excitatory conductances in cultured spinal cord neurons
5. l-Aspartic acid induces a region of negative slope conductance in the current-voltage relationship of cultured spinal neurons
6. Actions of verapamil on the excitability of cultured neurones
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9. Magnesium gates glutamateactivated channels in mouse central neurones
10. S-Glutamate: its interactions with spinal neurons
11. Excitatory amino acids