Analysis of pharmacokinetic data using parametric models. II. Point estimates of an individual's parameters

Journal of Pharmacokinetics and Biopharmaceutics

Volumn 13, Issue 5, 1985, Pages 515-540

  Sheiner, Lewis B ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

data analysis; estimation; identifiability; least squares; models; optimization; regression

Indexed keywords

COMPUTER ANALYSIS; DATA ANALYSIS; MODEL; NONBIOLOGICAL MODEL; NONHUMAN; PHARMACOKINETICS; PRIORITY JOURNAL; THEORETICAL STUDY;

DATA COLLECTION; HUMAN; INDIVIDUALITY; MODELS, STRUCTURAL; PHARMACEUTICAL PREPARATIONS; STATISTICS; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0022373283     PISSN: 0090466X     EISSN: 15738744     Source Type: Journal    
DOI: 10.1007/BF01059333     Document Type: Article

References (26)

1. Analysis of pharmacokinetic data using parametric models. I. Regression models
2. Forecasting individual pharmacokinetics
3. Evaluation of methods for estimating population pharmacokinetic parameters. I. Michaelis-Menten model; Routine clinical pharmacokinetic data
4. Evaluation of methods for estimating pharmacokinetic parameters. II. Biexponential model and experimental pharmacokinetic data
5. Evaluation of methods for estimating pharmacokinetic parameters. III. Monoexponential model: Routine clinical pharmacokinetic data
6. Alternative approaches to estimation of population pharmacokinetic parameters; Comparison with NONMEM
7. A priori identifiability analysis in pharmacokinetic experiment design
8. Parameter and structural identifiability concepts and ambiguities: A critical review and analysis
9. General treatment of linear mamillary models with elimination from any compartment as used in pharmacokinetics
10. Necessary and sufficient structural condition for local identifiability of a system with linear compartments
11. Counter examples of a sufficient condition for local identifiability in a linear compartment system
12. A note on the generation of random normal deviates
13. A pseudorandom number generator for the System 360
14. Computers, models and optimization in physiological kinetics
15. Pharmacokinetic parameter estimates from several least squares procedures: Superiority of extended least squares
16. Quasi-likelihood functions
17. Adaptive M-Estimation with Independent Nonidentically Distributed Data
18. Statistical robustness: One view of its use in applications today
19. Robust alternatives to least squares curve fitting
20. Adaptive robust procedures: A partial review and some suggestions for future applications and theory
21. Sampling and Bayes' inference in scientific modeling and robustness
22. Outlier..........s
23. Parameter estimation for nonlinear models with emphasis on compartmental models