Enzymatic amplification of β-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia

Science

Volumn 230, Issue 4732, 1985, Pages 1350-1354

  Saiki, Randall K ^a   Scharf, Stephen ^a   Faloona, Fred ^a   Mullis, Kary B ^a   Horn, Glenn T ^a   Erlich, Henry A ^a   Arnheim, Norman ^a,b  

^a NOVARTIS PHARMA AG   (Switzerland)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA-GLOBIN GENOMIC SEQUENCES; ENZYMATIC AMPLIFICATION; GENOMIC DNA; RESTRICTION SITE ANALYSIS; SICKLE CELL ANEMIA;

BIOCHEMISTRY - DNA SEQUENCES; ENZYMES;

BIOMEDICAL ENGINEERING;

HEMOGLOBIN BETA CHAIN;

BLOOD AND HEMOPOIETIC SYSTEM; DIAGNOSIS; GENE SEQUENCE; HEREDITY; HUMAN; HUMAN CELL; PREGNANCY; PRENATAL DIAGNOSIS; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SICKLE CELL ANEMIA;

ALLELES; ANEMIA, SICKLE CELL; BASE SEQUENCE; DNA RESTRICTION ENZYMES; DNA-DIRECTED DNA POLYMERASE; ESCHERICHIA COLI; GENE AMPLIFICATION; GLOBINS; HUMANS; LABORATORY TECHNIQUES AND PROCEDURES; NUCLEIC ACID HYBRIDIZATION; POLYMORPHISM, GENETIC;

EID: 0022372670     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.2999980     Document Type: Article

References (0)