Long term effects of cyclophosphamide on testicular function

British Medical Journal (Clinical research ed.)

Volumn 291, Issue 6507, 1985, Pages 1457-1460

  Watson, A R ^a   Rance, C P ^a   Bain, J ^b  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b MOUNT SINAI HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPHOSPHAMIDE; GONADORELIN;

ADVERSE DRUG REACTION; ANDROGEN BLOOD LEVEL; AZOOSPERMIA; CANCER CHEMOTHERAPY; CHILD; CHILDHOOD; CLINICAL ARTICLE; DRUG THERAPY; ENDOCRINE SYSTEM; FOLLITROPIN BLOOD LEVEL; HUMAN; INTOXICATION; LEYDIG CELL; LIBIDO; MALE GENITAL SYSTEM; OLIGOSPERMIA; PRIORITY JOURNAL; PROLACTIN BLOOD LEVEL; REPRODUCTIVE TOXICITY; SPERMATOGENESIS; SPERMATOZOON DENSITY; TESTIS; TESTIS FUNCTION; TESTIS INTERSTITIAL CELL FAILURE; THERAPY;

ADULT; CYCLOPHOSPHAMIDE; DOSE-RESPONSE RELATIONSHIP, DRUG; GONADORELIN; HUMAN; MALE; OLIGOSPERMIA; PUBERTY; SPERM COUNT; SPERMATOGENESIS; TESTIS; TIME FACTORS;

EID: 0022370652     PISSN: 02670623     EISSN: None     Source Type: Journal    
DOI: 10.1136/bmj.291.6507.1457     Document Type: Article

References (26)

1. Barratt, T.M., Soothill, J.F. Controlled trial of cyclophosphamide in steroid-sensitive relapsing nephrotic syndrome of childhood. Lancet 1970;2:479–482.
2. Chiu, J., McLaine, P.N., Drummond, K.N. A controlled prospective study of cyclophosphamide in relapsing corticosteroid-responsive, minimal-lesion nephrotic syndrome in childhood. J Pediatr 1973;82:607–613.
3. Spitzer, A., Gordillo, P.G., Houston, I.B., Travis, L.B. Prospective, controlled trial of cyclophosphamide therapy in children with the nephrotic syndrome. Report of the International Study of Kidney Disease in Children. Lancet 1974;2:423–427.
4. Fairley, K.F., Barrie, J.U., Johnson, W. Sterility and testicular atrophy related to cyclophosphamide therapy. Lancet 1972;1:568–569.
5. Kumar, R., Biggart, J.D., McEvoy, J., McGeown, M.G. Cyclophospharnide and reproductive function. Lancet 1972;1:1212–1214.
6. Etteldorf, J.N., West, C.D., Pitcock, J.A., Williams, D.L. Gonadal function, testicular histology, and meiosis following cyclophosphamide therapy in patients with nephrotic syndrome. J Pediatr 1976;88:206–212.
7. Lentz, R.D., Bergstein, J., Steffes, M.W., et al. Postpubertal evaluation of gonadal function following cyclophosphamide therapy before and during puberty. J Pediatr 1977;91:385–394.
8. Hsu, A.C., Folami, A.O., Bain, J., Rance, C.P. Gonadal function in males treated with cyclophosphamide for nephrotic syndrome. Fertil Steril 1979;31:173–177.
9. Buchanan, J.D., Fairley, K.F., Barrie, J.U. Return of spermatogenesis after stopping cyclophosphamide therapy. Lancet 1975;2:156–157.
10. Penso, J., Lippe, B., Ehrlich, R., Smith, F.G. Testicular function in prepubertal and pubertal male patients treated with cyclophosphamide for nephrotic syndrome. J Pediatr 1974;84:831–836.
11. Pennisi, A.J., Grushkin, C.M., Lieberman, E. Gonadal function in children with nephrosis treated with cyclophosphamide. AmJ Do Child 1975;129:315–318.
12. Kirkland, R.T., Bongiovanni, A.M., Comfeld, D., McCormick, J.B., Parks, J.S., Tenore, A. Gonadotropin responses to luteinizing releasing factor in boys treated with cyclophosphamide for nephrotic syndrome. J Pediatr 1976;89:941–944.
13. Cantu, J.-M., Scaglia, H.E., Medina, M., et al. Inherited congenital normofunctional testicular hyperplasia and mental deficiency. Hum Genet 1976; 33:23–33.
14. Chapman, R.M., Sutcliffe, S.B., Rees, L.H., Edwards, C.R.W., Malpas, J.S. Cyclical combination chemotherapy and gonadal function. Retrospective study in males. Lancet 1979;1:265–269.
15. Rance, C.P., Arbus, G.S., Balfe, J.W. Management of the nephrotic syndrome in children. Pediatr Clin North Am 1976;23:735–750.
16. Trompeter, R.S., Evans, P.R., Barratt, T.M. Gonadal function in boys with steroid-responsive nephrotic syndrome treated with cyclophosphamide for short periods. Lancet 1981;1:1177–1179.
17. Parra, A., Santos, D., Cervantes, C., Sojo, I., Carranco, A., Cortes-Gallegos, V. Plasma gonadotropins and gonadal steroids in children treated with cyclophosphamide. J Pediatr 1978;92:117–124.
18. Rapola, J., Koskimies, O., Huttunen, N.P., et al. Cyclophosphamide and the pubertal testis. Lancet 1973;1:98–99.
19. Chong, A.P., Walters, C.A., Weinrieb, S.A. The neglected laboratory test. The semen analysis. J Androl 1983;4:280–282.
20. Steinberg, A.D., Plotz, P.H., Wolff, S.M., Wong, V.G., Agus, S.G., Decker, J.L. Cytotoxic drugs in treatment of nonmalignant disease. Ann Intern Med 1972;76:619–642.
21. Farkas, L.G. Basic morphological data of external genitalia in 177 healthy central European men. AmJ Phys Anthropol 1971;34:325–328.
22. Arneil, G.C. Cyclophosphamide and the prepubertal testis. Lancet 1972;2:1259–1260.
23. Bain, J., Moskowitz, J.P., Clapp, J.J. LH and FSH response to gonadotropin releasing (GnRH) in normospermic, oligospermic and azoospermic men. Arch Androl 1978;1:147–152.
24. Rosen, S.W., Weintraub, B.D. Monotropic increase of serum FSH correlated with low sperm count in young men with idiopathic oligospermia and aspermia. J Clin Endocrinol Metab 1971;32: 410–416.
25. Bain, J. Male hypogonadism. Compr Ther 1983;9:17–24.
26. DeGroot, G.W., Fairman, C., Winter, J.S.D. Cyclophosphamide and the prepubertal gonad: a negative report. J Pedtatr 1974;84:123–125.