Evidence for chromosome instability in vivo in bloom syndrome: Increased numbers of micronuclei in exfoliated cells

Human Genetics

Volumn 71, Issue 3, 1985, Pages 187-191

  Rosin, Miriam P ^a   German, J ^b  

^a BRITISH COLUMBIA CANCER RESEARCH CENTRE   (Canada)

^b NEW YORK BLOOD CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOM SYNDROME; CENTRAL NERVOUS SYSTEM; CHROMOSOME; CLINICAL ARTICLE; CONGENITAL DISORDER; EPITHELIUM CELL; HEREDITY; HISTOLOGY; HUMAN; INSTABILITY; METHODOLOGY; MICRONUCLEUS; PRIORITY JOURNAL;

ADULT; AGED; BLOOM SYNDROME; CELL NUCLEUS; CHEEK; CHILD; CHILD, PRESCHOOL; CHROMOSOME ABERRATIONS; FEMALE; HETEROZYGOTE; HOMOZYGOTE; HUMAN; MALE; MIDDLE AGE; MOUTH MUCOSA; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0022364961     PISSN: 03406717     EISSN: 14321203     Source Type: Journal    
DOI: 10.1007/BF00284570     Document Type: Article

References (23)

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3. Heterozygous carriers for Bloom syndrome exhibit a spontaneously i increased micronucleus formation in cultured fibroblasts
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5. Patterns of neoplasia associated with the chromosome-breakage syndromes
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8. Bloom's syndrome. VII. Progress report for 1978
9. Bloom's syndrome. XI. Progress report for 1983
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13. No increased chromosome breakage iin three Bloom's syndrome heterozygotes
14. The cytogenetics of the “chromosome-breakage syndromes”
15. Chemical mutagen testing on in vivo somatic mammalian cells
16. Cytogenetic investigation in a new case of Bloom's syndrome
17. Quantitating the synergistic effect of smoking and alcohol consumption with the micronucleus test on human buccal mucosa cells
18. Micronuclei in exfoliated human cells as an internal dosimeter for exposures to carcinogens
19. Micronuclei in exfoliated human cells as a tool for studies in cancer risk and cancer intervention
20. Application of the micronucleus test to exfoliated cells of high cancer risk groups: tobacco chewers
21. Elevated frequency of micronucleated cells in the buccal mucosa of individuals at high risk for oral cancer: betel quid chewers
22. Reduction with vitamin A and beta-carotene administration of proportion of micronucleated buccal mucosal cells in Asian betel nut and tobacco chewers
23. Bloom's syndrome: evidence for an increased mutation frequency in vivo