Interactions of codeine-7,8-oxide (codeine-epoxide), as a new metabolite of codeine, with multiple opiate receptors

General Pharmacology

Volumn 16, Issue 4, 1985, Pages 379-381

  Konno, Fukio ^c   Sato, Yuka ^c   Togashi, Kunimi ^c   Takayanagi, Issei ^a   Hirobe, Masaaki ^b  

^a TOHO UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

CODEINE; CODEINE 7,8 OXIDE; CODEINE EPOXIDE; DIHYDROMORPHINE H 3; ENKEPHALIN[2 ALANINE 5 LEUCINE] H 3; ETHYLKETAZOCINE H 3; NALOXONE; OPSONIN; RADIOISOTOPE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BRAIN; CENTRAL NERVOUS SYSTEM; DRUG EFFICACY; DRUG RECEPTOR BINDING; IN VITRO STUDY; METABOLISM; NONHUMAN; PHARMACOKINETICS; PRIORITY JOURNAL; RAT;

ANIMALS; BRAIN; CELL MEMBRANE; CODEINE; CYCLAZOCINE; DIHYDROMORPHINE; ENKEPHALIN, LEUCINE; ENKEPHALIN, LEUCINE-2-ALANINE; ETHYLKETOCYCLAZOCINE; GUANOSINE TRIPHOSPHATE; MALE; RADIOLIGAND ASSAY; RATS; RATS, INBRED STRAINS; RECEPTORS, OPIOID; SODIUM CHLORIDE;

EID: 0022362318     PISSN: 03063623     EISSN: None     Source Type: Journal    
DOI: 10.1016/0306-3623(85)90199-5     Document Type: Article

References (12)

1. Differential regulation by guanine nucleotides of opiate agonist and antagonist receptor interactions
2. Rat vas deferens: a specific bioassay for endogenous opiate peptides
3. Endogenous opioid peptides: multiple agonists and receptors
4. Protein measurement with Folin Phenol Reagent
5. The binding spectrum of narcotic analgesic drugs with different agonist and antagonist properties
6. Pharmacology of opioids
7. The effects of morphine-and nalorphine-like drugs in the nondependent and morphine-dependent chronic spinal dogs
8. Opiate receptor binding of agonists and antagonists affected differentially by sodium
9. 3H-methionine enkephalin, an opioid peptide
10. Pharmacological properties of codeine-7,8-oxide (codeine-epoxide), a new metabolite of codeine
11. Effects of epoxides of heroin, morphine and codeine on the electrically stimulated guinea pig ileum
12. Codeine-7,8-oxide (4,5-epoxy-7,8-methoxy-17-methylmorphine-6-ol) Identification as a metabolite of codeine