Comparative trial of ketoconazole and nystatin for prevention of fungal infection in neutropenic patients treated in a protective environment

Journal of Infectious Diseases

Volumn 152, Issue 6, 1985, Pages 1257-1263

  Shepp, David H ^a   Klosterman, Ann ^a   Siegel, Martin S ^a   Meyers, Joel D ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B; BETA LACTAM ANTIBIOTIC; COTRIMOXAZOLE; CYCLOSPORIN; GENTAMICIN; HYDROCORTISONE; KETOCONAZOLE; NYSTATIN; POLYMYXIN; POVIDONE IODINE; TOBRAMYCIN; VANCOMYCIN;

ADVERSE DRUG REACTION; BLOOD AND HEMOPOIETIC SYSTEM; BONE MARROW TRANSPLANTATION; CANDIDA; CANDIDA ALBICANS; CLINICAL ARTICLE; COLONY; DIET; DIGESTIVE SYSTEM; DRUG COMPARISON; DRUG EFFICACY; DRUG THERAPY; FUNGUS; GASTROINTESTINAL SYMPTOM; GASTROINTESTINAL TOXICITY; HUMAN; IMMUNE DEFICIENCY; INTOXICATION; LIVER TOXICITY; MYCOSIS; ORAL DRUG ADMINISTRATION; PATIENT COMPLIANCE; PREVENTION; PRIORITY JOURNAL; THERAPY; TORULOPSIS GLABRATA;

AGRANULOCYTOSIS; CANDIDA ALBICANS; CANDIDIASIS; CLINICAL TRIALS; COMPARATIVE STUDY; ENVIRONMENT, CONTROLLED; HUMAN; KETOCONAZOLE; MYCOSES; NEUTROPENIA; NYSTATIN; PATIENT COMPLIANCE; RANDOM ALLOCATION; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0022356206     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/152.6.1257     Document Type: Article

References (25)

1. Chang H-Y, Rodriguez V, Narboni G, Bodey GP, Luna MA, Freireich EJ. Causes of death in adults with acute leukemia. Medicine (Baltimore) 1976;55:259-268.
2. Meyers JD, Thomas ED. Infection complicating bone marrow transplantation. In; Rubin RH, Young LS, eds. Clinical approach to infection in the immunocompromised host. New York: Plenum, 1982:507-551.
3. DeGregorio MW, Lee WMF, Ries CA. Candida infections in patients with acute leukemia: ineffectiveness of nystatin prophylaxis and relationship between oropharyngeal and systemic Candidiasis. Cancer 1982;50:2780-274.
4. Carpentieri U, Haggard ME, Lockhart LH, Gustavson LP, Box QT, West EF. Clinical experience in prevention of Candidiasis by nystatin in children with acute lymphocytic leukemia. J Pediatr 1978;92:593-595.
5. Schimpff SC, Greene WH, Young VM, Fortner CL, Jepsen L, Cusack N, Block JB, Wiernik PH. Infection prevention in acute nonlymphocytk leukemia: laminar air flow room reverse isolation with oral, nonabsorbable antibiotic prophylaxis. Ann Intern Med 1975;82:351-358.
6. Buckner CD, Clift RA, Sanders JE, Meyers JD, Counts GW, Farewell VT, Thomas ED. Protective environment for marrow transplant recipients: a prospective study. Ann Intern Med 1978;89:893-901.
7. Van Cutsem J. The antifungal activity of kétoconazole. Am J Med 1983;74(Suppl 1B):9-15.
8. Hurd DD, Canafax DM, Metzler DM, Peterson PK, Randomized study between kétoconazole and nystatin as fungal prophylaxis in acute-leukemia [abstract no. 133]. In: Second International Symposium on Infections in the Immunocompromised Host. 1982.
9. Siegel MS, Murphy M, Counts GW, Meyers JD. Prophylactic kétoconazole for prevention of fungal infection in bone marrow transplant patients [abstract no. 166]. In: Program and abstracts of the 22nd Interscience Conference on Antimicrobial Agents and Chemotherapy. Washington, DC: American Society for Microbiology, 1982.
10. Hurd DD, Canafax DM, Peterson PK. Fungal prophylaxis during intensive chemotherapy: randomized trial of high dose kétoconazole versus nystatin [abstract no. 18]. In: Third International Symposium on Infection in the Immunocompromised Host. 1984.
11. Hann IM, Corringham R, Keaney M, Noone P, Fox J, Szawat-kowski, M, Prentice HG, Blacklock HA, Shannon M, Gascoigne E, Boesen E, Hoffbrand AV. Kétoconazole versus nystatin plus amphotericin B for fungal prophylaxis in severely immunocompromised patients. Lancet 1982;1:826-829.
12. Jones PG, Kauffman CA, McAuliffe LS, Liepman MK, Bergman AG. Efficacy of kétoconazole vs. nystatin in prevention of fungal infections in neutropenic patients. Arch Intern Med 1984;144:594-599.
13. Meunier-Carpentier F. Treatment of mycoses in cancer patients. Am J Med 1983;74(Suppl 67):74-79.
14. De Jongh C, Finley R, Joshi J, Newman K, Wiernik P, Schimpff S. A comparison of kétoconazole to nystatin: prophylaxis of fungal infection in neutropenic patients [abstract no. 497]. In: Program and abstracts of the 22nd Interscience Conference on Antimicrobial Agents and Chemotherapy. Washington, DC: American Society for Microbiology, 1982.
15. Acuna G, Winston DJ, Young LS. Kétoconazole prophylaxis of fungal infections in the granulocytopenic patient [abstract no. 852]. In Program and abstracts of the 21st Interscience Conference on Antimicrobial Agents and Chemotherapy. Washington, DC: American Society for Microbiology, 1981.
16. Meunier-Carpentier F, Kiehn TE, Armstrong D. Fungemia in the immunocompromised host: changing patterns, an- tigenemia, high mortality. Am J Med 1981;71:363-370.
17. Myerowtiz RL, Pazin GJ, Allen CM. Disseminated candidiasis. Changes in incidence, underlying diseases, and pathology. Am J Clin Pathol 1977;68:29-38.
18. Sandford GR, Merz WG, Wingard JR, Charache P, Saral R. The value of fungal surveillance cultures as predictors of systemic fungal infections. J Infect Dis 1980;142:503-9.
19. Young RC, Bennett JE, Geelhoed GW, Levine AS. Funge-mia with compromised host resistance: a study of 70 cases. Ann Intern Med 1974;80:605-612.
20. Hermans PE, Keys TF. Antifungal agents used for deep-seated mycotic infections. Mayo Clin Proc 1983;58:223-31.
21. Stenderup A, Pedersen GT. Yeasts of human origin. Acta Pathol Microbiol Scand 1962;54:462-472.
22. Aisner J, Schimpff SC, Sutherland JC, Young VM, Wiernik PH. Torulopsis glabrata infections in patients with cancer. Am J Med 1976;61:23-28.
23. Valdivieso M, Luna M, Bodey GP, Rodriquez V, Gróschel D. Fungemia due to Torulopsis glabrata in the compromised host. Cancer 1976;38:1750-1756.
24. Ferguson RM, Sutherland DER, Simmons RL, Najarían JS. Kétoconazole, cyclosporin metabolism, and renal transplantation. Lancet 1982;2:882-883.
25. Dierperink H, Moller J. Kétoconazole and cyclosporin. Lancet 1982;2:1217.