Calcitonin gene-related peptide is a potent inhibitor of substance P degradation

European Journal of Pharmacology

Volumn 115, Issue 2-3, 1985, Pages 309-311

  Le Greves, Pierre ^a   Nyberg, Fred ^a   Terenius, Lars ^a   Hökfelt, Tomas ^b  

^a UPPSALA UNIVERSITY   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Calcitonin gene related peptide; Somatostatin; Substance P; Substance P endopeptidase

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; SOMATOSTATIN; SUBSTANCE P; VASOPRESSIN;

CEREBROSPINAL FLUID; DOSE RESPONSE; DRUG COMPARISON; DRUG RESPONSE; HUMAN; PRIORITY JOURNAL; SUBSTANCE P ENDOPEPTIDASE;

CALCITONIN GENE-RELATED PEPTIDE; HUMAN; KINETICS; NERVE TISSUE PROTEINS; PEPTIDE FRAGMENTS; SOMATOSTATIN; SPINAL CORD; SUBSTANCE P; SUPPORT, NON-U.S. GOV'T; VASOPRESSINS;

EID: 0022347682     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(85)90706-X     Document Type: Article

References (12)

1. Alternative RNA-processing in calcitonin gene expression generates mRNAs encoding different polypeptide products
2. Calcitonin gene-related peptide immunoreactivity in the spinal cord of man and eight other species
3. Intrathecal substance P elicits a caudally directed biting and scratching behavior in mice
4. Purification and characterization of a membrane-bound substance-P-degrading enzyme from human brain
5. Coexistence of peptides and classical neurotransmitters
6. Characterization of substance P(1–7) and (1–8) generating enzyme in human cerebrospinal fluid
7. Substance P
8. Behavioral evidence that substance P may be a spinal cord sensory neurotransmitter
9. Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing
10. Measurement of substance P metabolites in rat CNS
11. Intrathecal substance P and somatostatin in rats: behaviors indicative of sensation
12. Immunoreactive calcitonin gene-related peptide and substance P coexist in sensory neurons to the spinal cord and interact in spinal behavioral responses of the rat, 1984