Genetic polymorphism of mephenytoin p(4′)‐hydroxylation: difference between Orientals and Caucasians.

British Journal of Clinical Pharmacology

Volumn 19, Issue 4, 1985, Pages 483-487

  Jurima, M ^a   Inaba, T ^a   Kadar, D ^a   Kalow, W ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

MEPHENYTOIN;

4 HYDROXYMEPHENYTOIN; CAUCASIAN; CONTROLLED STUDY; DRUG ANALYSIS; DRUG DETERMINATION; DRUG METABOLISM; DRUG URINE LEVEL; ETHNIC OR RACIAL ASPECTS; GAS CHROMATOGRAPHY; GENETIC POLYMORPHISM; HEREDITY; HUMAN; HUMAN EXPERIMENT; HYDROXYLATION; KIDNEY; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL;

ADOLESCENT; ADULT; AGED; CANADA; CAUCASOID RACE; CHINA; CHROMATOGRAPHY, GAS; COMPARATIVE STUDY; FEMALE; HUMAN; HYDANTOINS; HYDROXYLATION; JAPAN; MALE; MEPHENYTOIN; MIDDLE AGE; MONGOLOID RACE; POLYMORPHISM (GENETICS); SUPPORT, NON-U.S. GOV'T;

EID: 0022220338     PISSN: 03065251     EISSN: 13652125     Source Type: Journal    
DOI: 10.1111/j.1365-2125.1985.tb02673.x     Document Type: Article

References (22)

1. Polymorphic hydroxylation of S‐mephenytoin and its relationship to debrisoquine phenotype
2. Substrate specificity of the form of cytochrome P‐450 catalyzing the 4‐hydroxylation of debrisoquine in man
3. Variation between individuals and populations in the acetylation of isoniazid and its significance for the treatment of pulmonary tuberculosis
4. Variability in caffeine metabolism
5. Human liver alcohol dehydrogenase variations. Improved separation methods using prolonged high voltage starch‐gel electrophoresis and isoelectric focusing
6. Liver alcohol dehydrogenase and aldehyde dehydrogenase in the Japanese: Isozyme variation and its possible role in alcohol intoxi‐cation
7. Mephenytoin and sparteine pharmaco‐genetics in Canadian Caucasians
8. A human cytochrome P‐450 characterized by inhibition studies as the sparteine/debrisoquine monooxygenase
9. Sparteine oxidation by the human liver: Absence of inhibition by mephenytoin
10. Ethnic difference in drug metabolism: Debrisoquine 4‐hydroxylation in Caucasians and Orientals
11. A method for studying drug metabolism in populations: Racial differences in amobarbital metabolism
12. Nortriptyline kinetics in Japanese and Americans
13. Mephenytoin hydroxylation deficiency: Kinetics after repeated doses
14. A new drug hydroxylation polymorphism in man: The incidence of mephenytoin hydroxylation deficient phenotypes in a European population study
15. Stereoselective metabolism of mephenytoin in man
16. A population and familial study of the defective alicyclic hydroxylation of debrisoquine among Egyptians
17. A study of the debrisoquine hydroxylation polymorphism in a Nigerian population
18. Difference in erythrocyte catechol‐o‐methyltransferase activity between Orientals and Caucasians: Difference in levodopa tolerance
19. Desipramine pharmacokinetics in Chinese and Caucasian volunteers
20. Diphenhydramine in Oriental and Caucasians
21. 3 polymorphisms in ethnic Chinese and Indians of West Malaysia
22. Debrisoquine hydroxylation polymorphism among Ghanaians and Caucasians