A comparison of chloroquine and pyrimethamine as malaria chemoprophylactics in young nigerian children

Transactions of the Royal Society of Tropical Medicine and Hygiene

Volumn 79, Issue 5, 1985, Pages 722-727

  Bradley Moore, Alice M ^a   Greenwood, A K ^a   Bradley, A K ^a   Akintunde, A ^b   Attai, E D E ^b   Fleming, A F ^b   Bartlett, Anne ^c   Biowell, D E ^c   Voller, A ^c   Kirkwooo, Betty R ^d   Gilles, H M ^e  

^a AHMADU BELLO UNIVERSITY   (Nigeria)

^b Bello University   (Nigeria)

^c INSTITUTE OF ZOOLOGY   (United Kingdom)

^d LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^e LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHLOROQUINE; PYRIMETHAMINE;

CANCER CHEMOTHERAPY; CLINICAL ARTICLE; DRUG COMPARISON; HUMAN; ORAL DRUG ADMINISTRATION; PLASMODIUM; PROTOZOON; THERAPY;

ANTIBODIES; CHLOROQUINE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FERRITINS; FOLIC ACID; HEMODYNAMIC PROCESSES; HUMANS; INFANT; MALARIA; PYRIMETHAMINE; VOMITING;

PROTOZOA;

EID: 0022199728     PISSN: 00359203     EISSN: 18783503     Source Type: Journal    
DOI: 10.1016/0035-9203(85)90203-2     Document Type: Article

References (15)

1. Bjorkman, A., Brohult, J., Sirleaf, V., Willcox, M. and Bengtsson, E. (1980). Plasmodium falciparum resistance to pyrimethamine and chlorproguanil—host or parasite dependent? Annals of Tropical Medicine and Parasitology, 74, 245-248.
2. Bradley-Moore, A. M. (1982). Immunosuppression and malaria. MD Thesis, University of London.
3. Bradley-Moore, A. M., Greenwood, B. M., Bradley, A. K., Bartlett, A., Bidwell, D. E., Voller, A., Kirkwood, B. R. &and Gilles, H. M. (1985a). Malaria chemoprophylaxis with chloroquine in young Nigerian children. 1. Its effect on mortality, morbidity and the prevalence of malaria. Annals of Tropical Medicine and Parasitology,(in press).
4. Bradley-Moore, A. M., Greenwood, B. M., Bradley, A. K., Bartlett, A., Bidwell, D. E., Voller, A., Craske J., Kirkwood, B. R. &and Gilles, H. M. (1985b). Malaria chemoprophylaxis with chloroquine in young Nigerian children. 2. Its effect on the immune response to vaccination. Annals of Tropical Medicine and Parasitology, (in press)
5. Bradley-Moore, A. M., Greenwood, B. M., Bradley, A. K., Akintunde, A., Attai, E. D. E., Fleming, A. F., Flynn, F. V., Kirkwood, B. R. &and Gilles, H. M. (1985c). Malaria chemoprophylaxis with chloroquine in young Nigerian children. 4. Its effect on haematological measurements. Annals of Tropical Medicine and Parasitology, (in press).
6. Fleming, A. F., Comley, L. &and Stenhouse, N. S. (1971). Assay of serum and whole blood folate by a modified aseptic addition technique. American Journal of Clinical Nutrition, 24, 1257-1264.
7. Lucas, A. O., Hendrickse, R. G., Okubadejo, O. A., Richards, W. H. G., Neal, R. A. &and Kofie, B. A. K. (1969). The suppression of malaria parasitaemia by pyrimethamine in combination with dapsone or sulphor- methoxine. Transactions of the Royal Society of Tropical Medicine and Hygiene, 63, 216-229.
8. McGregor, I. A., Hall, P. J., Williams, K., Hardy, C. L. S. &and Turner, M. W. (1966). Demonstration of circulating antibodies to Plasmodium falciparum by gel diffusion techniques. Nature, 210, 1384-1386.
9. Morley, D. (1971). Malaria in childhood. Tropical Doctor, 1, 159-161.
10. Onori, E. (1984). The problem of Plasmodium falciparum drug resistance south of the Sahara. Bulletin of the World Health Organization, 62 (Suppl.), 55-62.
11. Poonampalam, J. T. (1978). A comparative study of malaria prophylaxis in Peninsular Malaysia using chloroquine and a combination of sulphadoxine and pyrimethamine. Journal of Tropical Medicine and Hygiene, 81, 198-203.
12. Poonampalam, J. T., Seow, C. L. &and Roy, O. S. (1976). A comparative study of the efficacy of chloroquine and a combination of dapsone and pyrimethamine in Peninsular Malaysia. Journal of Tropical Medicine and Hygiene, 79, 220-225.
13. Walker, O., Dawodu, A. H., Adeyokunnu, A. A., Salako, L. A. &and Alvan, G. (1983). Plasma chloroquine and desethylchloroquine concentrations in children during and after chloroquine treatment for malaria. British Journal of Clinical Pharmacology, 16, 701-705.
14. Weidekamm, E., Plozza-Nottebrock, H., Forgo, I. &and Dubach, U. C. (1982). Plasma concentrations of pyrimethamine and sulfadoxine and evaluation of pharmacokinetic data by computerised curve fitting. Bulletin of the World Health Organization, 60, 115-122.
15. Williamson, W. A. &and Greenwood, B. M. (1978). Impairment of the immune response to vaccination after acute malaria. Lancet, i, 1328-1329.