Studies on antigenicity of the polyethylene glycol (PEG)-modified uricase

International Journal of Immunopharmacology

Volumn 7, Issue 5, 1985, Pages 725-730

  Jun ichi Tsuji, ^a   Katsumi Hirose, ^a   Etsuko Kasahara, ^b   Maki Naitoh, ^b   Itary Yamamoto, ^b  

^a TOYOBO CO LTD   (Japan)

^b OKAYAMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

MACROGOL; URATE OXIDASE;

ANAPHYLAXIS; ANIMAL EXPERIMENT; ANTIGENICITY; DRUG EFFICACY; GUINEA PIG; NONHUMAN; PRIORITY JOURNAL; RABBIT; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMAL; ANTIBODY FORMATION; EPITOPES; GUINEA PIGS; POLYETHYLENE GLYCOLS; RABBITS; SUPEROXIDE DISMUTASE; URATE OXIDASE;

EID: 0022181599     PISSN: 01920561     EISSN: None     Source Type: Journal    
DOI: 10.1016/0192-0561(85)90158-4     Document Type: Article

References (12)

1. Alteration of immunological properties of bovine serum albumin by covalent attachment of polyethylene glycol
2. Effect of covalent attachment of polyethylene glycol on immunogenicity and circulating life of bovine liver catalase
3. The use of esters of N-hydroxysuccinimide in peptide synthesis
4. Properties of two urate oxidases modified by the covalent attachment of poly(ethylene glycol)
5. Hypouricaemic effect of polyethyleneglycol modified urate oxidase
6. Determination of free amino groups in proteins by trinitrobenzensulfonic acid
7. Synthesis of glycyl-L-tryptophylglycine substituted by poly(ethylene oxide) at both the carboxy and the amino end groups
8. Modification of uricaemia and the excretion of uric acid nitrogen by an enzyme of fungal origin
9. Uricolytic activity of purified uricase in two human beings
10. Improved modification of yeast uricase with polyethylene glycol, accompanied with nonimmunoreactivity towards anti-uricase serum and high enzymic activity
11. Antibodies against polyethylene glycol produced in animals by immunization with monomethoxy polyethylene glycol modified proteins
12. Preparation of a non-immunogenic arginase by the covalent attachment of polyethylene glycol