Species Differences in the Binding of [3H]Nitrobenzylthioinosine to the Nucleoside Transport System in Mammalian Central Nervous System Membranes: Evidence for Interconvertible Conformations of the Binding Site/Transporter Complex

Journal of Neurochemistry

Volumn 45, Issue 2, 1985, Pages 527-535

  Hammond, James R ^a   Clanachan, Alexander S ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Binding; Cortical membranes; Nucleoside transport; 3H Nitrobenzylthioinosine

Indexed keywords

ADENOSINE; DIAZEPAM; DIPYRIDAMOLE; RADIOISOTOPE;

ANIMAL CELL; BIOLOGICAL MODEL; BRAIN CELL; CELL MEMBRANE; CENTRAL NERVOUS SYSTEM; DOG; DOSE RESPONSE; DRUG INHIBITION; DRUG RECEPTOR BINDING; DRUG RESPONSE; DRUG SENSITIVITY; GUINEA PIG; MOUSE; NITROBENZYLTHIOINOSINE H 3; NITROBENZYLTHIOINOSINE PHOSPHATE; NONHUMAN; NUCLEOSIDE TRANSPORT; PHARMACOKINETICS; PRIORITY JOURNAL; RAT;

ADENOSINE; ANIMAL; BINDING SITES; BIOLOGICAL TRANSPORT, ACTIVE; BRAIN; CELL MEMBRANE; DIAZEPAM; DIPYRIDAMOLE; DOGS; ERYTHROCYTES; FEMALE; GUINEA PIGS; HUMAN; INOSINE; MALE; MICE; NUCLEOSIDES; RABBITS; RATS; RATS, INBRED STRAINS; SPECIES SPECIFICITY; SUPPORT, NON-U.S. GOV'T; THIOINOSINE;

EID: 0021996006     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.1985.tb04020.x     Document Type: Article

References (46)

1. Inhibition of adenosine accumulation into guinea‐pig ventricle by benzodiazepines
2. Mediated transport of nucleosides in human erythrocytes. Specific binding of the inhibitor nitrobenzylthioinosine to nucleoside transport sites in the erythrocyte membrane
3. Initial rate kinetics and evidence for duality of mediated transport of adenosine, related purine nucleosides, and nucleoside analogues in L1210 cells
4. Drug interactions with the CNS nucleotide transport system
5. Effect of adenosine uptake inhibition on the nature and potency of theophylline as a presynaptic adenosine receptor antagonist
6. Binding of nitrobenzylthioinosine to high‐affinity sites on the nucleoside‐transport mechanism of HeLa cells
7. Adenosine receptors: targets for future drugs
8. Diazepam inhibition of adenosine uptake in the CNS: lack of effect on adenosine kinase
9. The classification of adrenoceptors (adrenergic receptors). An evaluation from the standpoint of receptor theory
10. The isolation of nerve endings from the brain: an electron‐microscopic study of cell fragments derived by homogenization and centrifugation
11. Benzodiazepines inhibit the binding of nitrobenzylthioinosine, a nucleoside transport inhibitor, to CNS membranes
12. Inhibition of the site‐specific binding of nitrobenzylthioinosine, an inhibitor of nucleoside transport, to CNS membranes
13. Distribution of nucleoside transport sites in guinea‐pig brain
14. Heterogeneity of high affinity nitrobenzylthioinosine binding sites in mamalian cortical membranes: multiple forms of CNS nucleoside transporters
15. 3H]Nitrobenzylthioinosine binding to the guinea pig CNS nucleoside transport system: a pharmacological characterization
16. Benzodiazepine inhibition of nucleoside transport in human erythrocytes
17. Initial rate kinetics of the transport of adenosine and 4‐amino‐7‐(β‐D‐ribofuranosyl)pyrrolo[2,3‐d] pyrimidine (Tubercidin) in cultured cells
18. Inhibitors of nucleoside and nucleotide metabolism
19. A species difference in the uptake of adenosine by heart
20. Nucleoside transport in human and sheep erythrocytes: evidence that nitrobenzylthioinosine binds specifically to functional nucleoside‐transport sites
21. Nucleoside translocation in sheep reticulocytes and fetal erythrocytes: a proposed model for the nucleoside transporter
22. Species differences in nucleoside transport: a study of uridine transport and nitrobenzylthioinosine binding by mammalian erythrocytes
23. Erythrocyte nucleoside transport: asymmetrical binding of nitrobenzylthioinosine to nucleoside permeation sites
24. Nucleoside transport in human erythrocytes: a simple carrier with directional symmetry in fresh cells, but with directional asymmetry in cells from outdated blood
25. Kinetics of nitrobenzylthioinosine binding to the human erythrocyte nucleoside transporter
26. Adenosine uptake by erythrocytes of man, rat and guinea‐pig and its inhibition by hexobendine and dipyridamole
27. Species differences in action and elimination of adenosine after dipyridamole and hexobendine
28. The kinetics of dissociation of the inhibitor of nucleoside transport, nitrobenzylthioinosine, from the high‐affinity binding sites of cultured hamster cells
29. Protein measurement with the folin phenol reagent
30. Adenosine transport and metabolism in mouse leukemia cells and in canine thymocytes and peripheral blood leukocytes
31. 3H]Nitrobenzylthioinosine binding as a probe for the study of adenosine uptake sites in brain
32. Nucleoside transport. I. A mediated process in human erythrocytes
33. 3H]nitrobenzylthioinosine binding to adenosine uptake sites in brain
34. Transport of nucleoside drugs in animal cells
35. The effect of various centrally active drugs on adenosine uptake by the central nervous system
36. Species differences in renal vascular effects of dipyridamole and in the potentiation of adenosine action by dipyridamole
37. Enhancement of coronary vasodilating action of adenosine by dilazep and dipyridamole in the dog
38. Nucleoside transport. Photoaffinity labelling of high‐affinity nitrobenzylthioinosine binding sites in rat and guinea pig lung
39. Potentiation of adenosine and the adenine nucleotides by dipyridamole
40. Physiological roles for adenosine and adenosine 5′‐triphosphate in the nervous system
41. Cell‐membrane receptors for purines
42. Uridine transport in concanavalin A‐ and lipopolysaccharide‐activated mouse lymphocytes
43. Nucleoside transport in heart: species differences in nitrobenzylthioinosine binding, adenosine accumulation, and druginduced potentiation of adenosine action
44. Kinetic and thermodynamic studies on nitrobenzylthioinosine binding to the nucleoside transporter of Chinese hamster ovary cells
45. Nucleoside transport in rat cerebral cortical synaptosomal membrane: a high affinity probe study
46. Do benzodiazepines bind at adenosine uptake sites in CNS