Terfenadine: A Review of its Pharmacodynamic Properties and Therapeutic Efficacy

Drugs

Volumn 29, Issue 1, 1985, Pages 34-56

  Sorkin, E M ^a   Heel, R C ^a  

^a ADIS INTERNATIONAL LIMITED   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; ASTEMIZOLE; AZATADINE; CHLORPHENIRAMINE; CLEMASTINE; CYPROHEPTADINE; DEXCHLORPHENIRAMINE; DIAZEPAM; DIPHENHYDRAMINE; HISTAMINE; HISTAMINE H1 RECEPTOR; ISOPRENALINE; MEPYRAMINE; MEQUITAZINE; PLACEBO; PROMETHAZINE; TELDAN; TERFENADINE; TRIPELENNAMINE; TRIPROLIDINE; UNCLASSIFIED DRUG;

ADVERSE DRUG REACTION; DIGESTIVE SYSTEM; DROWSINESS; DRUG ABSORPTION; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG ELIMINATION; DRUG HYPERSENSITIVITY; DRUG MECHANISM; DRUG METABOLISM; DRUG RECEPTOR BINDING; FATIGUE; GASTROINTESTINAL SYMPTOM; HUMAN; INTOXICATION; NERVOUS SYSTEM; NEUROTOXICITY; OLFACTORY SYSTEM; PERENNIAL RHINITIS; PHARMACOKINETICS; PHARMACOLOGY; PRIORITY JOURNAL; REVIEW; RHINITIS; SEDATION; SKIN TOXICITY; TERFENADINE C 14; THERAPY; WEAKNESS;

ANIMAL; ASTHMA; BENZHYDRYL COMPOUNDS; EXERTION; HAY FEVER; HISTAMINE H1 ANTAGONISTS; HUMAN; HYPNOTICS AND SEDATIVES; KINETICS; PARASYMPATHOLYTICS; PSYCHOMOTOR PERFORMANCE; RHINITIS, ALLERGIC, PERENNIAL; SEROTONIN ANTAGONISTS; SKIN DISEASES; SYMPATHOLYTICS; TERFENADINE; TISSUE DISTRIBUTION;

EID: 0021971505     PISSN: 00126667     EISSN: 11791950     Source Type: Journal    
DOI: 10.2165/00003495-198529010-00002     Document Type: Article

References (70)

1. A comparative study of the safety and efficacy of terfenadine in perennial allergic rhinitis
2. 3H] WB 4101 binding sites in the brain
3. Terfenadine in allergic rhinitis. A comparative trial of a new antihistamine versus chlorpheniramine and placebo
4. Terfenadine, safety and tolerance in controlled clinical trials
5. The effect of diphenhydramine alone and in combination with ethanol on histamine skin response and mental performance
6. Comparative study of terfenadine in allergic skin of patients in France
7. Effects of two antihistamine drugs on actual driving performance
8. Clinical investigation of terfenadine, a non-sedating antihistamine
9. Clinical studies of terfenadine in seasonal allergic rhinitis
10. Controlled trial of terfenadine and chlorpheniramine maleate in perennial rhinitis
11. Clinical pharmacology (dose/response, duration of action, tolerance). Terfenadine one year later. Comparison of European experience
12. Treatment of chronic idiopathic urticaria with terfenadine
13. Antihistaminic effect of terfenadine
14. Antihistaminic effect of terfenadine: A new piperidine-type antihistamine
15. A kinetic study of the antihistaminic effect of terfenadine
16. Performance studies with antihistamines
17. Radioimmunoassay for terfenadine in human plasma
18. 2 receptor antagonists on the dermographic response
19. Clinical studies with terfenadine in seasonal allergic rhinitis in France
20. Double-blind study of the treatment of acute pollen allergy with antihistamines
21. Treatment of pruritis due to chronic obstructive liver disease
22. CNS effects of the antihistamines diphenhydramine and terfenadine (RMI 9918)
23. Critical flicker-fusion frequency, EEG, and psychoactive drugs
24. Terfenadine in allergic rhinitis in children — preliminary report
25. Pharmacokinetics and biotransformation studies of terfenadine in man
26. Prophylaxis of seasonal allergic rhinitis with a new antihistaminic drug
27. Comparative study of the efficacy and tolerance of terfenadine and clemastine in patients with seasonal allergic rhinitis
28. Preclinical safety studies with terfenadine
29. Inhibitory activity of terfenadine on histamine-induced skin wheals in man
30. A double-blind trial of terfenadine and placebo in hay fever using a substitution technique for non-responders
31. 1 receptor effects of antihistamine agents
32. 1 antihistamines in itch
33. Mechanism of action of antipruritic drugs
34. The effect of terfenadine on dermographic wealing
35. Some clinical pharmacological studies with terfenadine, a new antihistamine drug
36. Metabolic fate of terfenadine in rats
37. Metabolic disposition of terfenadine in laboratory animals
38. Children with allergies. Terfenadine suspension plus placebo
39. Use of a new antihistaminic agent (terfenadine) in allergic rhinitis
40. Comparison of the effects of azatadine and terfenadine on human performance
41. A multicentre controlled trial of terfenadine, dexchlorpheniramine, and placebo in allergic rhinitis
42. Clinical evaluation of a new selective H i receptor antagonist: Terfenadine
43. Experiences with an expanded test during outpatient therapy with Teldane in Switzerland
44. 1-receptor antagonist (terfenadine)
45. Effects of terfenadine and diphenhydramine alone or in combination with diazepam or alcohol on psychomotor performance and subjective feelings
46. Antihistamines and visual function: Studies on dynamic acuity and the pupillary response to light
47. 1-histamine receptor antagonists, astemizole and terfenadine
48. 1-antagonist mequitazine: Studies on performance and visual function
49. 1) antagonists in the rat
50. Bioavailability of terfenadine in man
51. Terfenadine in exercise induced asthma
52. Chronopharmacological study of antihistamines in man with special references to terfenadine
53. Chronopharmacologic study of antihistaminic agents, with special reference to terfenadine
54. 1-receptors and sedative properties of antihistamines. Assessment in the case of terfenadine
55. Comparative double-blind study of the efficacy and safety of oral terfenadine as against oral dextro-chlorpheniramine in the treatment of allergic dermatosis
56. Reason and the rash
57. Subacute toxicity and recovery tests on terfenadine in rats
58. The use of a human bioassay in determining the bioequivalence of two formulations of the antihistamine terfenadine
59. The effect of large doses of H1 antagonists in urticaria
60. Sedation and antihistamines
61. 1-receptors in vivo determined by receptor binding techniques
62. Terfenadine, the first non-sedating antihistamine
63. Experiences with Teldane in the treatment of pollinosis