Endogenous Concentration and Subcellular Distribution of Estrogens in Normal and Malignant Human Breast Tissue

Cancer Research

Volumn 45, Issue 6, 1985, Pages 2900-2906

  van Landeghem, A A J ^a   Poortman, J ^a   Nabuurs, M ^a   Thijssen, J H H ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; ANDROSTENEDIOL; PRASTERONE;

BREAST; BREAST CANCER; ENDOCRINE SYSTEM; FEMALE GENITAL SYSTEM; HUMAN; HUMAN CELL; MENOPAUSE; POSTMENOPAUSE; PRIORITY JOURNAL;

ADOLESCENT; ADULT; AGE FACTORS; AGED; ANDROGENS; ANDROST-5-ENE-3 BETA,17 BETA-DIOL; BREAST; BREAST NEOPLASMS; CELL NUCLEUS; CYTOSOL; ESTRADIOL; FEMALE; HUMAN; MENOPAUSE; MIDDLE AGE; PRASTERONE; SUPPORT, NON-U.S. GOV'T;

EID: 0021970734     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Abul-Hajj, Y. J. Metbolism of dehydroepiandrosterone by hormone dependent and hormone independent human breast carcinoma. Steroids, 26: 488-500, 1975.
2. Δ4-5β-reductase in human mammary tumors. Steroids, 33:115-124, 1979.
3. Abul-Hajj, Y. J. Relationship between estrogen receptors, 17β-hydroxysteroid dehydrogenase and estrogen content in human breast cancer. Steroids, 34: 217-225, 1979.
4. Abul-Hajj, Y. J., Iverson, R., and Kiang, D. T. Aromatization of androgens by human breast cancer. Steroids, 33:205-222, 1979.
5. Abul-Hajj, Y. J., Iverson, R., and Kiang, D. T. Estradiol 17▓-dehydrogenase and estradiol binding in human mammary tumors. Steroids, 33: 477-483, 1979.
6. Abul-Hajj, Y. J., Iverson, R., and Kiang, D. T. Metabolism of pregnenolone by human breast cancer. Evidence for 17▒-hydroxylase and 17, 20-lyase. Steroids, 34: 817-827, 1979.
7. Alsbach, G. P. J., Franck, E. R., Poortman, J., and Thijssen, J. H. H. Estradiol and estrone levels in subcellular fractions of the human endometrium and myometrium during the normal menstrual cycle. Contraception, 27:409-421, 1983.
8. Batra, S., Bengtsson, L. P., and Sjöberg, N. O. Interrelation between plasma and tissue concentrations of 17▓-oestradiol and progesterone during human pregnancy. Clin. Endocrinol., 11: 603-610, 1979.
9. Cortés-Gallegos, V., Gallegos, A. J., Sanchez-Basurto, C., and Rivadeneyra, J. Estrogens peripheral levels vs estrogen tissue concentration in the human female reproductive tract. J. Steroid Biochem., 6:15-20, 1975.
10. Dao, T. L. Metabolism of estrogens in breast cancer. Btochim. Biophys. Acta, 560: 397-426, 1979.
11. Deshpande, N., Carson, O., Di Martino, L., and Tarquini, A. Biogenesis of steroid hormones by human mammary gland in vivo and in vitro. Eur. J. Cancer, 12:271-276, 1976.
12. Duvivier, J. D., Colin, C., Hustin, J., Albert, A., Lavigne, J., Dive, G., and Montfort, F. Comparison of levels of cytosol estrogen receptors with “arterial” and “venous” concentration of gonadic steroids in mammary tumors. Clin. Chim. Acta, 112: 21-32, 1981.
13. Edery, M., Goussard, J., Dehennin, L., SchoHer, R., Reiffsteck, J., and Dros-dowsky, M. A. Endogenous oestradiol-M17▓ concentration in breast tumours determined by mass fragrnentography and by radioimmunoassay: relationship to receptor content. Eur. J. Cancer, 17:115-120, 1981.
14. Rshman, J., Nissefoaum, J. S., Menendez-Botet, C. J., and Schwartz, M. K. Estrone and estradiol content in human breast tumours: relationship to estradiol receptors. J. Steroid Biochem., 8:893-896, 1977.
15. Griffiths, K., Jones, D., Cameron, E. H. D., Gleave, E. N., and Forrest, A. P. M. Transformation of steroids by mammary cancer tissue. In: T. L Dao (ed.), Estrogen Target Tissues and Neoplasia, pp. 151-162. Chicago: Chicago University Press, 1972.
16. Jensen, E. V., Suzuki, T., Kawashima, T., Stumpf, W. E., Jungblut, P. W., and DeSombre, E. R. A two-step mechanism for the interaction of estradiol with rat uterus. Proc. Natl. Acad. Sei. USA, 59: 632-638, 1968.
17. Li, K., and Adams, J. B. Aromatization of testosterone and oestrogen receptor levels in human breast cancer. J. Steroid Biochem., 14:269-272, 1981.
18. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J. Protein measurement with the Follin phenol reagent. J. Biol. Chem., 793; 265-275, 1951.
19. Maynard, P. V., Brownsey, B. G., and Griffiths, K. Oestradiol levels in fractions of human breast tumours. J. Endocrinol., 77:62p-63p, 1978.
20. Maynard, P. V., and Griffiths, K. Clinical, pathological and biochemical aspects of the oestrogen receptor in primary human breast cancer. In: R. J. B. King (ed.), Steroid Receptor Assays in Human Breast Tumors: Methodological and Clinical Aspects, pp. 86-99. Cardiff, Wales: Alpha Omega Publishing, Ltd., 1979.
21. McGuire, W. L., Pearson, O. H., and Segaloff, A. Predicting hormone responsiveness in human breast cancer. In: W. L. McGuire, P. P. Carbone, and E, P. Vollmer (eds.), Estrogen Receptors in Human Breast Cancer, pp. 17-30. New York: Raven Press, 1975.
22. Means, A. R., and Hamilton, T. H. Early estrogen action: concomitant stimulations within two minutes of nuclear RNA synthesis and uptake of RNA precursor by the uterus. Proc. Natl. Acad. Sci. USA, 56:1594-1598, 1966.
23. Miller, W. R., Hawkins, R. A., and Forrest, A. P. M. Significance of aromatase activity in human breast cancer. Cancer Res. (Suppl), 42:3365s-3368s, 1982.
24. Miller, W. R., Shivas, A. A., and Forrest, A. P. M. Factors affecting testosterone metabolism by human breast tissues. Clin. Oncol., 4: 77-85, 1978.
25. MNIington, D., Jenner, D. A., Jones, T., and Griffiths, K. Endogenous steroid concentrations in human breast tumours determined by high-resolution mass fragmentography. Biochem. J., 139; 473-475, 1974.
26. Nagai, R., Kataoka, M., Kobayashi, S., Ishihara, K., Tobioka, N., Nakashima, K., Naruse, M., Saito, K., and Sakuma, S. Estrogen and progesterone receptors in human breast cancer with concomitant assay of plasma 17β-estradiol, progesterone and prolactin levels. Cancer Res., 39:1835-1840, 1979.
27. Perel, E., Davis, S., and Killinger, D. W. Androgen metabolism in male and female breast tissue. Steroids, 37: 345-352, 1981.
28. Pewnim, T., Adams, J. B., and Ho, K. P. Estrogen sulfurylation as an alternative indicator of hormone dependence in human breast cancer. Steroids, 39: 47-52, 1982.
29. Poortman, J., Prenen, J. A. C., Schwarz, F., and Thijssen, J. H. H. Interaction of, 17β-diol with estradiol and dihydrotestosterone receptors in human myometrial and mammary cancer tissues. J. Clin. Endocrinol. Metab., 40: 373-379, 1975.
30. Poortman, J., Thijssen, J. H. H., and Schwarz, F. Androgen production and conversion to estrogens in normal postmenopausal women and in selected breast cancer patients. J. Clin. Endocrinol. Metab., 37:101-109, 1973.
31. Poortman, J., Thijssen, J. H. H., and Schwarz, F. Steroid receptors in human reproductive tissues. In: J. L. Wrttliff and O. Dapunt (eds.), Steroid Receptors and Hormone Dependent Neoplasia, pp. 45-58. New York: Masson Publishing, Inc., 1980.
32. Puca, G. A., Sica, V., and Nola, E. Identification of a high affinity nuclear acceptor site for estrogen receptor of calf uterus. Proc. Natl. Acad. Sci. USA, 71: 979-983. 1974.
33. Rao, G. S. Mode of entry of steroid and thyroid hormones into cells. Mol. Cell. Endocrinol., 21: 97-108, 1981.
34. Saez, S., Martin, P. M., and Chouvet, C. D. Estradiol and progesterone receptor levels in human breast adenocarcinoma in relation to plasma oestrogen andprogesterone levels. Cancer Res., 38: 3468-3473, 1978.
35. Schmidt-GoJIwitzer, M., Eiletz, J., Genz, T., and Pollow, K. Determination of estradiol, estrone and progesterone in serum and myometrium: correlation with the content of sex steroid receptors and 17ß-hydroxysteroid dehydrogenase activity throughout the menstrual cycle. J. Clin. Endocrinol. Metab., 49: 370-376, 1979.
36. Thevo, N. O., Carlström, K., Gustafsson, J. A., Gustaffson, S., Nordeskjold, V., Sköktefors, H., and Wränge, Ö. Oestrogen receptors and peripheral serum levels of oestradiol-17ß in patients with mammary carcinoma. Eur. J. Cancer, 14:1337-1340, 1978.
37. Thijssen, J. H. H., Poortman, J., and Schwarz, F. Androgens in postmenopausal breast cancer: excretion, production and interaction with estrogens. J. Steroid Biochem., 6: 729-734, 1975.
38. Thorsen, T., Tangen, M., and Stoa, K. F. Concentration of endogenous oestradiol as related to oestradiol receptor sites in breast tumor cytosol. Eur. J. Cancer Clin. Oncol., 18:333-337, 1982.
39. VaHent, K., Fehér, T., Bodrogi, L., and Ribai, Z. Steroid-Hormone-Gehalt der Brustsubstanz bei Mammatumoren. Chirurg, 53; 34-36, 1982.
40. van Haaften, M., Wiegerinck, M. H. A. M., Poortman, J., Haspels, A. A., and Thijssen, J. H. H. Progesterone receptors in human oestrogen target tissues. Maturitas, 4: 57-66, 1982.
41. van Landeghem, A. A. J. Hormones and breast cancer: endogenous concentration and subcellular distribution of oestrogens and androgens in normal and malignant human mammary tissue. Ph. D. Dissertation, University of Utrecht, 1983.
42. van Landeghem, A. A. J., Poortman, J., Deshpande, N., Di Martino, L., Tarquini, A., Thijssen, J. H. H., and Schwarz, F. Plasma concentration gradient of steroid hormones across human mammary tumours in vivo. J. Steroid Biochem., 14: 741-747, 1981.
43. van Landeghem, A. A. J., Poortman, J., Faber, J. A. J., and Thijssen, J. H. H. Absence of seasonal variation of estrogen receptor levels in human breast cancer tissue. Mol. Cell. Endocrinol., 23: 265-273, 1981.
44. van Landeghem, A. A. J., Poortman, J., Helmond-Agema, A., and Thijssen, J. H. H. Measurement of endogenous subcellular concentration of steroids in tissue. J. Steroid Biochem., 20:639-644, 1984.
45. van Landeghem, A. A. J., Poortman, J., Nabuurs, M., and Thijssen, J. H. H. Endogenous concentration and subcellular distribution of androgens in normal and malignant breast tissue. Cancer Res., 45:2907-2912, 1985.
46. Vareia, R. M., and Dao, T. L. Estrogen synthesis and estradiol binding by human mammary tumors. Cancer Res., 38:2429-2433, 1978.
47. Wang, D. Y. Androgens and breast cancer. Rev. Endocr. -related Cancer, 3: 19-24, 1979.
48. Wiegerinck, M. A. H. M., Poortman, J., Donker, T. H., and Thijssen, J. H. H. In vivo uptake and subcellular distribution of tritium labelled estrogens in human endometrium, myometrium, and vagina, J. Clin. Endocrinol. Metab., 56: 76-86, 1983.