Catecholamine Modulation of Rapid Potassium Shifts during Exercise

New England Journal of Medicine

Volumn 312, Issue 13, 1985, Pages 823-827

  Williams, Mark E ^a   Gervino, Ernest V ^a   Rosa, Robert M ^a   Landsberg, Lewis ^a   Young, James B ^a   Silva, Patricio ^a   Epstein, Franklin H ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; ALDOSTERONE; BICARBONATE; CATECHOLAMINE; GLUCOSE; INSULIN; NORADRENALIN; PHENTOLAMINE; POTASSIUM; PROPRANOLOL; RENIN;

ALPHA ADRENERGIC RECEPTOR BLOCKING; BETA ADRENERGIC RECEPTOR BLOCKING; BLOOD AND HEMOPOIETIC SYSTEM; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG MECHANISM; DRUG MONITORING; EXERCISE; HUMAN; HUMAN EXPERIMENT; INTRAVENOUS DRUG ADMINISTRATION; NERVOUS SYSTEM; NORMAL HUMAN; PRIORITY JOURNAL;

EID: 0021963592     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM198503283121304     Document Type: Article

References (23)

1. Wilkerson JE, Horvath SM, Gutin B, Molnar S, Diaz FJ. Plasma electrolyte content and concentration during treadmill exercise in humans. J Appl Physiol 1982; 53: 1529–39.
2. Hirche H, Schumacher E, Hagemann H. Extracellular K+ concentration and K+ balance of the gastrocnemius muscle of the dog during exercise. Pflugers Arch 1980; 387: 231–7.
3. Carlsson E, Fellenius E, Lundborg P, Svensson L. β-Adrenoreceptor blockers, plasma-potassium, and exercise. Lancet 1978; 2: 424–5.
4. Coester N, Elliott JC, Luft UC. Plasma electrolytes, pH, and ECG during and after exhaustive exercise. J Appl Physiol 1973; 34: 677–82.
5. Kilbum KH. Muscular origin of elevated plasma potassium during exercise. J Appl Physiol 1966; 21: 675–8.
6. Hazeyama Y, Sparks HV. A model of potassium ion efflux during exercise of skeletal muscle. Am J Physiol 1979; 236: R83–R90.
7. Christensen NJ, Galbo H. Sympathetic nervous activity during exercise. Annu Rev Physiol 1983; 45: 139–53.
8. Rosa RM, Silva P, Young JB, et al. Adrenergic modulation of extrarenal potassium disposal. N Engl J Med 1980; 302: 431–4.
9. DeFronzo RA, Bia M, Birkhead G. Epinephrine and potassium homeostasis. Kidney Int 1981; 20: 83–91.
10. Todd EP, Vick RL. Kalemotropic effect of epinephrine: analysis with adrenergic agonists and antagonists. Am J Physiol 1971; 220: 1964–9.
11. Williams ME, Rosa RM, Silva P, Brown RS, Epstein FH. Impairment of extrarenal potassium disposal by α-adrenergic stimulation. N Engl J Med 1984; 311: 145–9.
12. Akaike N. Sodium pump in skeletal muscle: central nervous system-induced suppression by α-adrenoceptors. Science 1981; 213: 1252–4.
13. Davis GC, Kissinger PT, Shoup RE. Strategies for determination of serum and plasma norepinephrine by reverse-phase liquid chromatography. Anal Chem 1981; 53: 156–9.
14. Young JB, Landsberg L. Adrenergic influence on peripheral hormone secretion. In: Kunos G, ed. Adrenoceptors and catecholamine action. Part B. New York: John Wiley, 1983:157–217.
15. Imura H, Kato Y, Ikeda M, Morimoto M, Yawata M. Effect of adrenergic-blocking or -stimulating agents on plasma growth hormone, immunoreactive insulin, and blood free fatty acid levels in man. J Clin Invest 1971; 50: 1069–79.
16. Giugliano D, Torella R, Sgambato S, D'Onofrio F. Effects of alpha- and beta-adrenergic inhibition and somatostatin on plasma glucose, free fatty acids, insulin, glucagon, and growth hormone responses to prostaglandin E1 in man. J Clin Endocrinol Metab 1979; 48: 302–8.
17. Galbo H, Christensen NJ, Hoist JJ. Catecholamines and pancreatic hormones during autonomic blockade in exercising man. Acta Physiol Scand 1977; 101: 428–37.
18. Westfall TC. Evidence that noradrenergic transmitter release is regulated by presynaptic receptors. Fed Proc 1984; 43: 1352–7.
19. Lim M, Linton RAF, Wolfe CB, Band DM. Propranolol, exercise, and arterial plasma potassium. Lancet 1981; 2: 591.
20. Clausen T. Adrenergic control of Na+ -K+ -homeostasis. Acta Med Scand [Suppl] 1983; 672: 111–5.
21. DeFronzo RA, Sherwin RS, Dillingham M, Hendler R, Tamborlane WV, Felig P. Influence of basal insulin and glucagon secretion on potassium and sodium metabolism: studies with somatostatin in normal dogs and in normal and diabetic human beings. J Clin Invest 1978; 61: 472–9.
22. Guerra SMO, Kitabchi AE. Comparison of the effectiveness of various routes of insulin injection: insulin levels and glucose response in normal subjects. J Clin Endocrinol Metab 1976; 42: 869–74.
23. Brown MJ, Brown DC, Murphy MB. Hypokalemia from beta2-receptor stimulation by circulating epinephrine. N Engl J Med 1983; 309: 1414–9.