Microbial phosphorylation of compactin (ML-236B) and related compounds

The Journal of Antibiotics

Volumn 38, Issue 3, 1985, Pages 328-332

  Naoki, Hideo ^b   Iwashita, Takashi ^b   Mizukawa, Yasumasa ^b  

^a TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

^b SUNTORY INSTITUTE FOR BIOORGANIC RESEARCH   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

5' PHOSPHOCOMPACTIC ACID; 5' PHOSPHOMONACOLIN K ACID; 5' PHOSPHOMONACOLIN L ACID; 5' PHOSPHOMONACOLIN X ACID; ACETIC ACID C 14; ALKALINE PHOSPHATASE; COMPACTIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; MEVINOLIN; MONACOLIN L; MONACOLIN X; RADIOISOTOPE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; DRUG ANALYSIS; DRUG COMPARISON; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG METABOLISM; DRUG SCREENING; DRUG STABILITY; FUNGUS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; INFRARED SPECTROMETRY; LIPOGENESIS; LIVER; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; RAT; ULTRAVIOLET SPECTROPHOTOMETRY;

ALKALINE PHOSPHATASE; ANIMALS; ANTI-BACTERIAL AGENTS; ANTICHOLESTEREMIC AGENTS; BIOTRANSFORMATION; CHEMISTRY; FUNGI; HYDROLYSIS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LOVASTATIN; NAPHTHALENES; PHOSPHORYLATION; RATS;

EID: 0021953898     PISSN: 00218820     EISSN: 18811469     Source Type: Journal    
DOI: 10.7164/antibiotics.38.328     Document Type: Article

References (8)

1. Endo, A.: Biological and pharmacological activity of inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase. Trends Biochem. Sci. 6: 10-13, 1981
2. Endo, A.: Specific non-sterol inhibitors of HMG-CoA reductase. In Regulation of HMG-CoA Reductase. Ed., B. PREISS, Academic Press, New York, 1984
3. Endo, A.; M. Kuroda & Y. Tsujita: ML-236A, ML-236B, and ML-236C, new inhibitors of cholestero-genesis produced by Penicillium citrinum. J. Antibiotics 29: 1336-1348, 1976
4. Endo, A.: Monacolin K, a new hypocholesterolemic agent produced by a Monascus species. J. Antibiotics 32: 852-854, 1979
5. Endo, A.; K. Hasumi & S. Negishi: Monacolins J and L, new inhibitors of cholesterol biosynthesis produced by Monascus ruber. J. Antibiotics 38: 420-422, 1985
6. Endo, A.; M. Kuroda & K. Tanzawa: Competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase by ML-236A and ML-236B, fungal metabolites having hypocholesterolemic activity. FEBS Lett. 72: 323-326, 1976
7. Endo, A.; S. Negishi, S. Murakawa & T. Takahashi: Assignment of 13C NMR spectrum of ML-236B and its biosynthesis (in Japanese). Abstracts of the Ann. Meet. Agric. Chem. Soc., Japan, p. 421, 1982
8. Kuroda, M. & A. Endo: Inhibition of in vitro cholesterol synthesis by fatty acids. Biochim. Biophys. Acta 486: 70-81, 1977