Anti-Transferrin Receptor Antibody Linked to Pseudomonas Exotoxin as a Model Immunotoxin in Human Ovarian Carcinoma Cell Lines

Cancer Research

Volumn 45, Issue 2, 1985, Pages 751-757

  Pirker, Robert ^a   FitzGerald, David J P ^a   Willingham, Mark C ^a   Pastan, Ira ^a   Hamilton, Thomas C ^a   Ozols, Robert F ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOTOXIN; PSEUDOMONAS EXOTOXIN; TRANSFERRIN; VERAPAMIL;

CELL LINE; ENDOCRINE SYSTEM; FEMALE GENITAL SYSTEM; HUMAN; HUMAN CELL; IN VITRO STUDY; OVARY CARCINOMA; PRIORITY JOURNAL; THERAPY;

ADP RIBOSE TRANSFERASES; BACTERIAL TOXINS; BREAST NEOPLASMS; CELL LINE; CELL SURVIVAL; COLONY-FORMING UNITS ASSAY; EXOTOXINS; FEMALE; HUMANS; IMMUNOTHERAPY; KINETICS; OVARIAN NEOPLASMS; RECEPTORS, CELL SURFACE; RECEPTORS, TRANSFERRIN; TIME FACTORS; TUMOR STEM CELL ASSAY; VERAPAMIL; VIRULENCE FACTORS;

EID: 0021949961     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Akiyama. S., Gottesman, M. M. F. Hanover, J. A., FitzGerald, D. J. P., Willingham, M. C., and Pastan, I. Verapamil enhances the toxicity of conjugates of epidermal growth factor with Pseudomonas exotoxin and anti-transferrin receptor with Pseudomonas exotoxin. J. Cell. Physiol., 120: 271–279,1984.
2. Bast, R. C., Jr., Klug, T. L., St. John, E., Jenison, E., Niloff, J. M., Lazarus, H., Berkowitz, R. S., Leavitt, T., Griffiths, C. T., Parker, L., Zurawski, V. R., Jr., and Knapp, R. C. A radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancer. N. Engl. J. Med., 309:883–887,1983.
3. Bernhard, M. I., Foon, K. A., Oeltmann, T. N., Key, M. E., Hwang, K. M., Clarke, G. C., Christensen, W. L., Hoyer, L. C., Hanna, M. G., Jr., and Oldham, R. K. Guinea pig line 10 hepatocarcinoma model: characterization of monoclonal antibody and in vivo effect of unconjugated antibody and antibody conjugated to diphtheria toxin A chain. Cancer Res., 43:4420–4428,1983.
4. Carlsson, J., Drevin, H., and Axen, R. Protein thiolation and reversible protein-protein conjugation. N-succinimidyl 3-(2-pyridyldithio)-propionate, a new heterobifunctional reagent. Biochem. J., 173: 723–737,1978.
5. Casellas, P., Brown, J. P., Gros, O., Gros, P., Hellström, I., Jansen, F. K., Poncelet, P., Roncucci, R., Vidal, H., and Hellström, K. E. Human melanoma cells can be killed in vitro by an immunotoxin specific for melanoma-associated antigen p97. Int. J. Cancer, 30: 437–443,1982.
6. Filipovich, A. H., Youle, R. J., Neville, D. M., Jr., Vallera, D. A., Quinones, R. R., and Kersey, J. H. Ex-vivo treatment of donor bone marrow with anti-T-cell immunotoxins for prevention of graft-versus-host disease. Lancet, 1:469–472, 1984.
7. FitzGerald, D. J. P., Trowbridge, I. S., Pastan, I., and Willingham, M. C. Enhancement of toxicity of anti-transferrin receptor antibody–Pseudomonas exotoxin conjugates by adenovirus. Proc. Natl. Acad. Sci. USA, 80, 4134–4138,1983.
8. FitzGerald, D. J. P., Waldmann, T. A., Willingham, M. C., and Pastan, I. Pseudomonas exotoxin–anti-TAC: cell-specific immunotoxin active against cells expressing the human T-cell growth factor receptor. J. Clin. Invest., 74: 966–971,1984.
9. Gale, R.P. Autologous bone marrow transplantation in patients with cancer. J. Am. Med. Assoc. 243: 540–542,1980.
10. Gatter, K. C., Brown, G., Trowbridge, I. S., Woolston, R. E., and Mason, D. Y. Transferrin receptors in human tissues: their distribution and possible clinical relevance. J. Clin. Pathol., 36: 539–545,1983.
11. Gilliland, D. G., Steplewski, Z., Collier, R. J., Mitchell, K. F., Chang, T. H., and Koprowski, H. Antibody-directed cytotoxic agents: use of monoclonal antibody to direct the action of toxin A chains to colorectal carcinoma cells. Proc. Natl. Acad. Sci. USA, 77: 4539–4543,1980.
12. Hamilton, T. C., Young, R. C., Louie, K. G., Behrens, B. C., McKoy, W. M., Grotzinger, K. R., and Ozols, R. F. Characterization of a xenograft model of human ovarian carcinoma which produces ascites and intraabdominal carcinomatosis in mice. Cancer Res., 44: 5286–5290,1984.
13. Hamilton, T. C., Young, R. C., McKoy, W. M., Grotzinger, K. R., Green, J. A., Chu, E. W., Whang-Peng, J., Rogan, A. M., Green, W. R., and Ozols, R. F. Characterization of a human ovarian carcinoma cell line (NIH: OVCAR-3) with androgen and estrogen receptors. Cancer Res., 43: 5379–5389,1983.
14. Haynes, B. F., Hemler, M., Cotner, T., Mann, D. L., Eisenbarth, G. S., Strominger, J. L., and Fauci, A. S. Characterization of a monoclonal antibody (5E9) that defines a human cell surface antigen of cell activation. J. Immunol., 127:347–351,1981.
15. Krolick, K. A., Yuan, D., and Vitetta, E. S. Specific killing of a human breast carcinoma cell line by a monoclonal antibody coupled to the A-chain of ricin. Cancer Immunol. Immunother., 12:39–41,1981.
16. Lesley, J., Domingo, D. L., Schulte, R., and Trowbridge, I. S. Effect of an antimurine transferrin receptor–ricin A conjugate on bone marrow stem and progenitor cells treated in vitro. Exp. Cell Res., 150:400–407,1984.
17. Pastan, I. H., and Willingham, M. C. Journey to the center of the cell: role of the receptosome. Science (Wash. DC), 274: 504–509,1981.
18. Ramakrishnan, S., and Houston, L. L. Inhibition of human acute lymphoblastic leukemia cells by immunotoxins: potentiation by chloroquine. Science (Wash. DC), 223: 58–61,1984.
19. Rogan, A. M., Hamilton, T. C., Young, R. C., Klecker, R. W., Jr., and Ozols, R. F. Reversal of Adriamycin resistance by verapamil in human ovarian cancer. Science (Wash. DC), 224: 994–996,1984.
20. Scatchard, G. The attractions of proteins for small molecules and ions. Ann. NY Acad. Sci., 57: 660–672,1949.
21. Slater, L. M., Murray, S. L., and Wetzel, M. W. Verapamil restoration of daunorubicin responsiveness in daunorubicin-resistant Ehrlich ascites carcinoma. J. Clin. Invest., 70:1131–1134,1982.
22. Sutherland, R., Delia, D., Schneider, C., Newman, R., Kemshead, J., and Greaves, M. Ubiquitous cell-surface glycoprotein on tumor cells is proliferation-associated receptor for transferrin. Proc. Natl. Acad. Sci. USA, 78, 4515–4519,1981.
23. Thorpe, P. E., and Ross, W. C. J. The preparation and cytotoxic properties of antibody-toxin conjugates. Immunol. Rev., 62:119–158,1982.
24. Trowbridge, I. S., and Domingo, L. D. Anti-transferrin receptor monoclonal antibody and toxin-antibody conjugates affect growth of human tumour cells. Nature (Lond.), 294:171–173,1981.
25. Tsukada, Y., Hurwitz, E., Kashi, R., Sela, M., Hibi, N., Hara, A., and Hirai, H. Chemotherapy by intravenous administration of conjugates of daunomycin with monoclonal and conventional anti-rat ɑ-fetoprotein antibodies. Proc. Natl. Acad. Sci. USA, 79, 7896–7899,1982.
26. Tsuruo, T., lida, H., Tsukagoshi, S., and Sakurai, Y. Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil. Cancer Res., 47:1967–1972,1981.
27. Vitetta, E. S., Krolick, K. A., Miyama-lnaba, M., Cushley, W., and Uhr, J. W. Immunotoxins: a new approach to cancer therapy. Science (Wash. DC), 219: 644–650,1983.
28. Youle, R. J., and Neville, D. M., Jr. Kinetics of protein synthesis inactivation by ricin–anti-Thy 1.1 monoclonal antibody hybrids. Role of the ricin B subunit demonstrated by reconstitution. J. Biol. Chem., 257:1598–1601,1982.
29. Young, R. C., Knapp, R. C., and Perez, C. A. Cancer of the ovary. In: V. T. DeVita, Jr., S. Hellman, and S. A. Rosenberg (eds.), Cancer: Principles and Practice of Oncology, 884–913. Philadelphia: J. B. Lippincott Co., 1982.