A New Generation of Phosphodiesterase Inhibitors: Multiple Molecular Forms of Phosphodiesterase and the Potential for Drug Selectivity

Journal of Medicinal Chemistry

Volumn 28, Issue 5, 1985, Pages 537-545

  Weishaar, Ronald E ^a   Cain, Michael H ^a   Bristol, James A ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (3 CHLOROANILINO) 4 PHENYLPHTHALAZINE; 1,2,3,4 TETRAHYDRO 5 [4 [N (3 HYDROXYBUTYL) N PHENYLCARBAMOYL]BUTOXY] 2 QUINOLINONE; 2 (2,4 DIMETHOXYPHENYL)IMIDAZO[4,5 B]PYRIDINE; 2 ACETAMIDO 6 METHYL 4 PROPYL 1,2,3 TRIAZOLO[4,3 A]PYRAZINE; 4 (3 BUTOXY 4 METHOXYBENZYL) 2 IMIDAZOLIDINONE; 4,5 DIHYDRO 6 [4 (1H IMIDAZOL 1 YL)PHENYL] 5 METHYL 3(2H) PYRIDAZINONE; 6 [4 [ (2 ETHOXY 2 PHENYLETHYL)PIPERAZINE 1 SULFONYL] 4 (N METHYLANILINO)QUINAZOLINE; AMIPIZONE; AMRINONE; BUFROLIN; CALMODULIN; CILOSTAMIDE; CILOSTAZOL; CYCLIC AMP; CYCLIC GMP; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; DIPYRIDAMOLE; ENOXIMONE; ETAZOLATE; IMAZODAN; OXAGRELATE; PAPAVERINE; PHOSPHODIESTERASE; PHOSPHODIESTERASE INHIBITOR; PIROXIMONE; ROLIPRAM; SULMAZOLE; THEOPHYLLINE; UNCLASSIFIED DRUG; VINPOCETINE; XANTHINE DERIVATIVE; ZAPRINAST;

1,2,3,4 TETRAHYDRO 5 [4 [N (3HYDROXYBUTYL) N PHENYLCARBAYL]BUTOXY] 2 QUINOLINONE; 1,2,3,4 TETRAHYDRO 6 (2,3,4,5 TETRAHYDRO 5 METHYL 3 OXO 6 PYRIDAZINYL) 1 METHYL 2 QUINOLINONE; 2 ACETAMIDO 6 METHYL 4 PROPYL 1,2,3 TRIAZOLO[4,3 A]PYRAZINE; 6 [4 [ (2 ETHOXY 2 PHENYLETHYL)PIPERAZINE 1 SULFONYL] 4 (N METHYLANILINO)QUINAZOLINE; ALLERGY; ANIMAL CELL; BLOOD AND HEMOPOIETIC SYSTEM; CHEMICAL STRUCTURE; CHROMATOGRAPHY; DOSE RESPONSE; DRUG ANALYSIS; DRUG COMPARISON; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG INHIBITION; DRUG INTERACTION; DRUG ISOLATION; DRUG MECHANISM; DRUG RESPONSE; DRUG SELECTIVITY; DRUG SYNTHESIS; ETRAZOLATE; GREAT BLOOD VESSEL; GUINEA PIG; HEART; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG DISEASE; NORMAL HUMAN; PREVENTION; PRIORITY JOURNAL; RAT; RESPIRATORY SYSTEM; SHORT SURVEY; SWINE; THERAPY; THROMBOCYTE AGGREGATION;

3',5'-CYCLIC-GMP PHOSPHODIESTERASE; 3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; ANIMAL; BLOOD PLATELETS; CALMODULIN; CARDIOTONIC AGENTS; GUINEA PIGS; HUMAN; HYPERSENSITIVITY; IN VITRO; LUNG DISEASES; MYOCARDIUM; PLATELET AGGREGATION; SUBSTRATE SPECIFICITY;

EID: 0021941937     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm50001a001     Document Type: Article

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