Preliminary results of M-VAC (methotrexate, vinblastine, doxorubicin and cisplatin) for transitional cell carcinoma of the urothelium

Journal of Urology

Volumn 133, Issue 3, 1985, Pages 403-407

  Sternberg, C N ^a   Yagoda, A ^a   Scher, H I ^a   Watson, R C ^b   Ahmed, T ^b   Weiselberg, L R ^b   Geller, N ^b   Hollander, P S ^b   Herr, H W ^b   Sogani, P C ^b  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; DEXAMETHASONE; DIPHENHYDRAMINE; DOXORUBICIN; METHOTREXATE; METOCLOPRAMIDE; VINBLASTINE; VINBLASTINE SULFATE;

ADVERSE DRUG REACTION; ALOPECIA; ANOREXIA; BLADDER; BLOOD AND HEMOPOIETIC SYSTEM; BONE MARROW DEPRESSION; CANCER COMBINATION CHEMOTHERAPY; CLINICAL ARTICLE; DRUG EFFICACY; DRUG THERAPY; GASTROINTESTINAL TOXICITY; HUMAN; INTOXICATION; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY; METASTASIS; NEPHROTOXICITY; PATHOLOGY; PRIORITY JOURNAL; SKIN TOXICITY; THERAPY; TRANSITIONAL CELL CARCINOMA; TUMOR REGRESSION; UROTHELIUM; VOMITING;

EID: 0021910302     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-5347(17)48996-8     Document Type: Article

References (16)

1. Yagoda A. Watson R.C. Gonzales-Vitale J.C. Grabstald H. Whitmore W.F. Cis-dichlorodiammineplatinum (II) in advanced bladder cancer Cancer Treat. Rep. 60 1976 917
2. Natale R.B. Yagoda A. Watson R.C. Whitmore W.F. Blumenreich M. Braun D.W. Jr. Methotrexate: an active drug in bladder cancer Cancer 47 1981 1246
3. Yagoda A. Watson R.C. Whitmore W.F. Grabstald H. Middleman M. Krakoff I.H. Adriamycin in advanced urinary tract cancer: experience in 42 patients and review of the literature Cancer 39 1977 279
4. Blumenreich M.S. Yagoda A. Natale R.B. Watson R.C. Phase II trial of vinblastine sulfate for metastatic urothelial tract tumors Cancer 50 1982 435
5. Schwartz S. Yagoda A. Natale R.B. Watson R.C. Whitmore W.F. Lesser M. Phase II trial of sequentially administered cisplatin, cyclophosphamide and doxorubicin for urothelial tract tumors J. Urol. 130 1983 681
6. Yagoda A. Chemotherapy for advanced urothelial cancer Sem. Urol. 1 1983 60
7. Ahmed, T., Yagoda, A., Needles, B., Scher, H. I., Watson, R. C. and Geller, N.: Vinblastine and methotrexate for advanced bladder cancer. J. Urol., in press.
8. Yagoda A. Chemotherapy of metastatic bladder cancer Cancer 45 1980 1879
9. Chello P.L. Sirotnak F.M. Dorick D.M. Moccio D.M. Schedule-dependent synergism of methotrexate and vincristine against murine L1210 leukemia Cancer Treat. Rep. 63 1979 1889
10. Khandekar J.D. Elson P.J. DeWys W.D. Improved activity and toxicity of cyclophosphamide (CTX), adriamycin (ADR) and cis-diamminedichloroplatinum (DDP), combination (CAD) as compared to DDP in disseminated transitional cell carcinomas of the urinary tract (DTCUT) Proc. Amer. Soc. Clin Oncol. 2 1983 143 abstract C-560
11. Gagliano R. Levin H. El-Bolkainy M.N. Wilson H.E. Stephens R.L. Fletcher W.S. Rivkin S.E. O’Bryan R.M. Coltman C.A. Jr. Saiki J.H. Stuckey W.J. Balducci L. Bonnet J.D. Dixon D.O. Adriamycin versus adriamycin plus cis-diamminedichloroplatinum (DDP) in advanced transitional cell bladder carcinoma. A Southwest Oncology Group Study. Amer J. Clin Oncol. 6 1983 215
12. Harker W.G. Freiha F.S. Shortliffe L.D. Meyers F.J. Hannigan J.F. Jr. Flam M.S. Torti F.M. Cisplatin, methotrexate, and vinblastine (CMV) chemotherapy (CT) for metastatic cancer of the uroepithelium Proc. Amer. Soc. Clin Oncol. 2 1983 135 abstract C-530
13. Oliver R.T.D. England H.R. Risdon R.A. Blandy J.P. Methotrexate in the treatment of metastatic and recurrent primary transitional cell carcinoma J. Urol. 131 1984 483
14. Natale R.B. Wheeler R.H. Ensminger W. Miller D. Cisplatin + dichloromethotrexate (DCM): a pharmacologically rational combination with high activity Proc. Amer. Ass. Cancer Res. 24 1983 166 abstract 659
15. Citrin D.L. Hogan T.F. Davis T.E. A study of cyclophosphamide, adriamycin, cis-platinum, and methotrexate in advanced transitional cell carcinoma of the urinary tract Cancer 51 1983 1
16. Tannock I.F. Gospodarowicz M. Evans W.K. Chemotherapy for metastatic transitional carcinoma of the urinary tract. A prospective trial of methotrexate, adriamycin, and cyclophosphamide (MAC) with cis-platinum for failure Cancer 51 1983 216