MRC trial of treatment of mild hypertension: Principal results

British Medical Journal (Clinical research ed.)

Volumn 291, Issue 6488, 1985, Pages 97-104

  Greenberg, G ^a  

^a NORTHWICK PARK HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BENDROFLUMETHIAZIDE; GUANETHIDINE; METHYLDOPA; PLACEBO; PROPRANOLOL;

ADVERSE DRUG REACTION; CARDIOVASCULAR SYSTEM; CENTRAL NERVOUS SYSTEM; CLINICAL TRIAL; CONTROLLED STUDY; DRUG COMPARISON; DRUG THERAPY; DYSPNEA; EPIDEMIOLOGY; GASTROINTESTINAL TOXICITY; GLUCOSE INTOLERANCE; GOUT; HEADACHE; HEART; HEART INFARCTION; HUMAN; HYPERTENSION; IMPOTENCE; INTOXICATION; ISCHEMIC HEART DISEASE; JOINT; LETHARGY; MAJOR CLINICAL STUDY; MALE GENITAL SYSTEM; MORTALITY; NAUSEA; NERVOUS SYSTEM; NEUROTOXICITY; ORAL DRUG ADMINISTRATION; PERIPHERAL VASCULAR SYSTEM; PREVENTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RAYNAUD PHENOMENON; RESPIRATORY SYSTEM; SEX; SKIN TEST; SKIN TOXICITY; SMOKING; STROKE; THERAPY; VERTIGO;

ADULT; BENDROFLUMETHIAZIDE; BLOOD PRESSURE; CEREBROVASCULAR DISORDERS; CLINICAL TRIALS; COMPARATIVE STUDY; CORONARY DISEASE; FEMALE; HUMAN; HYPERTENSION; MALE; MIDDLE AGE; PROPRANOLOL; RANDOM ALLOCATION; RISK; SEX FACTORS; SMOKING; SUPPORT, NON-U.S. GOV'T;

EID: 0021863832     PISSN: 02670623     EISSN: None     Source Type: Journal    
DOI: 10.1136/bmj.291.6488.97     Document Type: Article

References (25)

1. MRC Working Party on Mild to Moderate Hypertension. Randomised controlled trial of treatment for mild hypertension: design and pilot trial. Br Med J 1977; ii: 1437–40.
2. Hamilton M, Thompson EN, Wisniewski TKM. The role of blood pressure control in preventing complications of hypertension. Lancet 1964;i:235-8.
3. Veterans Administration Co-operative Study Group. Effects of treatment on morbidity in hypertension. Results in patients with diastolic blood pressures averaging 115 through 129 mm Hg. JAMA 1967;202:1028-34.
4. Carter AB. Hypotensive therapy in stroke survivors. Lancet 1970;i: 485-9.
5. Veterans Administration Co-operative Study Group. Effects of treatment on morbidity in hypertension II. Results in patients with diastolic blood pressure averaging 90 through 114 mm Hg.JAMA 1970;213:1143-52.
6. Miall WE, Chinn S. Screening for hypertension: some epidemiological observations. Br Med J 1974;iii:595-600.
7. Registrar General. Statistical Review of England and Wales, 1970. London: HMSO, 1971.
8. Medical, 8 Miall WE, Brennan PJ. Observations on the natural history of mild hypertension in the control groups of therapeutic trials. In: Gross F, Strasser T, eds. Mild hypertension, natural history and management. Tunbridge Wells: Pitman 1979:38-43.
9. Wright BM, Dore CF. A random-zero sphygmomanometer. Lancet 1970;i: 337–8.
10. Rose GA, Holland WW, Crowley EA. A sphygmomanometer for epidemiologists. Lancet 1964;i:296-300.
11. Aho H, Harmsen P, Hatano S, Marquardsen W, Smirnov VE, Strasser T. Cerebrovascular disease in the community; results of a WHO collaborative study. Bull WHO 1980;58:113-30.
12. World Health Organisation Regional Office for Europe. Myocardial infarction community registers. Copenhagen: WHO, 1976. (Public Health in Europe No 5.)
13. Pocock SJ. Group sequential methods in the design and analysis of clinical trials. Biometrika 1977;64:191-8.
14. Pocock SJ. Current issues in the design and interpretation of clinical trials. Br Med J 1985;290:39-42.
15. Baker RJ, Nelder JA- The GLIM system. Release 3. Oxford: Numerical Algorithms Group.
16. Brennan PJ, Greenberg G, Miall WE, Thompson SG. Seasonal variation in arterial blood pressure. Br Med J 1982;285:919-23.
17. hypertension. 17 Medical Research Council Working Party on Mild to Moderate Hypertension. Adverse reactions to bendrofluazide and propranolol for the treatment of mild Lancet 1981; ii:539-43.
18. WHO/ISH Mild Hypertension Liaison Committee. Trials of the treatment of mild hypertension. An interim analysis. Lancet 1982;i: 149–56.
19. Greenberg G, Thompson SG. The effect of smoking on blood pressure in mild hypertensives, and on their response to antihypertensive treatment. Journal of Hypertension 1984;2:553.
20. Medical Research Council Working Party on Mild to Moderate Hypertension. Ventricular extrasystoles during thiazide treatment: sub-study of MRC mild hypertension trial. Br Med J 1983;287:1249-53.
21. Multiple Risk Factor Intervention Trial Research Group. Multiple Risk Factor Intervention Trial. Risk Factor Changes and Mortality Results. JAMA 1982;248:1465-77.
22. Australian National Blood Pressure Study Management Committee. The Australian therapeutic trial in mild hypertension. Lancet 1980; i: 1261–7.
23. Hypertension Detection and Follow-up Program Co-operative Group. Five-year findings of the hypertension detection and follow-up program. (1) Reduction in mortality of persons with high blood pressure, including mild hypertension. (2) Mortality by race/sex and age. JAMA 1979;242:2562-77.
24. Alderman MH, Madhavan S. Management of the hypertensive patient: a continuing dilemma. Hypertension 1981;3:192-7.
25. Toth PJ, Horwitz RI. Conflicting clinical trials and the uncertainty of treating mild hypertension. Am J Med 1983;75:482-8.