Disposition of idebenone (cv-2619), a new cerebral metabolism improving agent, in rats and dogs

Journal of Pharmacobio-Dynamics

Volumn 8, Issue 6, 1985, Pages 457-467

  Kobayashi, Takuo ^a   Yoshida, Kiyoshi ^a   Tsukamoto, Takeji ^a   Torii, Hiroshi ^a   Tanayama, Shigeharu ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

brain subcellular distribution; cerebral metabolism improving agent; disposition; dog; idebenone (CV 2619); lacteal secretion; metabolite; placental transfer; plasma protein binding; rat

Indexed keywords

IDEBENONE; IDEBENONE C 14; RADIOISOTOPE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BIOAVAILABILITY; BRAIN METABOLISM; CENTRAL NERVOUS SYSTEM; DOG; DRUG DISTRIBUTION; DRUG METABOLISM; DRUG MILK LEVEL; NONHUMAN; PHARMACOKINETICS; PLACENTAL TRANSFER; PLASMA PROTEIN BINDING; PREGNANCY; RAT;

ANIMALS; AUTORADIOGRAPHY; BENZOQUINONES; BLOOD PROTEINS; BRAIN; CHROMATOGRAPHY, THIN LAYER; DOGS; ERYTHROCYTES; FECES; FEMALE; INTESTINAL ABSORPTION; MALE; PLACENTA; PREGNANCY; PROTEIN BINDING; QUINONES; RATS; RATS, INBRED STRAINS; SPECIES SPECIFICITY; SUBCELLULAR FRACTIONS; TISSUE DISTRIBUTION;

EID: 0021856724     PISSN: 0386846X     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb1978.8.457     Document Type: Article

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