Regional brain uptake of 2-deoxyglucose in N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism in the macaque monkey

Neuropharmacology

Volumn 24, Issue 6, 1985, Pages 587-591

  Crossman, A R ^a,b   Mitchell, I J ^a,b   Sambrook, M A ^a,b  

^a Department of Anatomy University of Manchester Manchester M13 9PT UK ^*

^b MANCHESTER UNIVERSITY NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; DEOXYGLUCOSE; LEVODOPA; RADIOISOTOPE;

ANIMAL EXPERIMENT; ANIMAL MODEL; CENTRAL NERVOUS SYSTEM; DRUG EFFICACY; DRUG THERAPY; GLOBUS PALLIDUS; INTOXICATION; MONKEY; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; THERAPY;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; ANIMAL; AUTORADIOGRAPHY; BRAIN; DEOXY SUGARS; DEOXYGLUCOSE; FEMALE; GLOBUS PALLIDUS; INJECTIONS, INTRAVENOUS; MACACA FASCICULARIS; PARKINSON DISEASE, SECONDARY; PYRIDINES; SUPPORT, NON-U.S. GOV'T; SYNAPSES; THALAMUS;

EID: 0021849088     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/0028-3908(85)90070-X     Document Type: Article

References (7)

1. A primate model of parkinsonism; selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
2. Chronic parkinsonism secondary to intravenous injection of meperidine analogues
3. Parkinsonism induced by 1-methyl-4-pheny1-1,2,3,6-tetrahydropyridine (MPTP): implications for treatment and the pathogenesis of Parkinson's disease
4. Cerebral glucose metabolism in Parkinson's disease
5. Activity-dependent energy metabolism in rat posterior pituitary primarily reflects sodium pump activity
6. 3H]-2-deoxyglucose in the brain of the monkey during experimental choreiform dyskinesia elicited by injection of a gamma-aminobutyric acid antagonist into the subthalamic nucleus
7. 14C] deoxyglucose method for the measurement of local cerebral glucose utilisation: theory, procedure, and normal values in the conscious and anaesthetized albino rat