Characterization of 1α-hydroxylation of vitamin D3 sterols by cultured alveolar macrophages from patients with sarcoidosis

Journal of Experimental Medicine

Volumn 161, Issue 4, 1985, Pages 755-765

  Adams, John S ^a   Gacad, Mercedes A ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIDIOL 1 MONOOXYGENASE; CALCIFEDIOL; CALCITRIOL; CALCIUM; COLECALCIFEROL; DEXAMETHASONE; GAMMA INTERFERON; GLUCOCORTICOID; OXYGENASE; RADIOISOTOPE;

1 HYDROXYCOLECALCIFEROL H 3; 1,24,25 TRIHYDROXYCOLECALCIFEROL H 3; 24,25 DIHYDROXYCOLECALCIFEROL H 3; BLOOD AND HEMOPOIETIC SYSTEM; CALCIFEDIOL H 3; CALCITRIOL H 3; CELL CULTURE; COLECALCIFEROL H 3; DRUG ANALYSIS; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG IDENTIFICATION; DRUG METABOLISM; ETIOLOGY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HYDROXYLATION; HYPERCALCEMIA; IN VITRO STUDY; MACROPHAGE; PHARMACOKINETICS; PRIORITY JOURNAL; RESPIRATORY SYSTEM; SARCOIDOSIS;

25-HYDROXYVITAMIN D3 1-ALPHA-HYDROXYLASE; ADULT; CALCITRIOL; CELLS, CULTURED; FEMALE; HUMAN; HYDROXYLATION; HYPERCALCEMIA; KINETICS; LUNG DISEASES; MACROPHAGES; MALE; MIDDLE AGE; PULMONARY ALVEOLI; SARCOIDOSIS; STEROID HYDROXYLASES; SUBSTRATE SPECIFICITY; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0021847794     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.161.4.755     Document Type: Article

References (27)

1. Papapoulos, S. E., T. L. Clemens, L.J. Fraher, I. G. Lewin, L. M. Sandler, and J. L. H. O’Riordan. 1979. 1,25-Dihydroxycholecalciferol in the pathogenesis of the hypercalcemia of sarcoidosis. Lancet. 1:627.
2. 3 is the probable cause for abnormal calcium metabolism in sarcoidosis. J. Clin. Invest. 64:218.
3. 3 by cultured pulmonary alveolar macrophages in sarcoidosis. J. Clin. Invest. 72:1856.
4. 3 produced by cultured alveolar macrophages in sarcoidosis. J. Clin. Endocrinol. Metab. In press.
5. Hunninghake, G. W., J. E. Gadek, S. Szapiel, I. J. Strumpf, O. Kawanani, V. J. Ferrans, B. A. Keogh, and R. G. Crystal. 1980. The human alveolar macrophage. Methods Cell Biol. 21 A:95.
6. Koski, I. E., D. G. Poplack, and R. M. Blacke. 1976. A nonspecific esterase stain for identification of monocytes and macrophages. In In Vitro Methods of Cell-mediated and Tumor Immunity. B. R. Bloom and J. R. David, editors. Academic Press, Inc., New York. 359-362.
7. Adams, J. S., T. L. Clemens, and M. F. Holick. 1981. Silica Sep-Pak preparative chromatography for vitamin D and its metabolites. J. Chromatogr. 226:198.
8. 450. A component of chick kidney 25- hydroxycholecalciferol-lα-hydroxylase. J. Biol. Chem. 249:3026.
9. Barbour, G. L., J. W. Coburn, E. Slatapolsky, A. W. Norman, and R. L. Horse. 1981. Hypercalcemia in an anephric patient with sarcoidosis: evidence for extrarenal generation of 1,25-dihydroxvitamin D. N. Engl. J. Med. 305:440.
10. Fukase, M., S.J. Birge, Jr., L. Rifas, L. V. Avioli, and L. R. Chase. 1982. Regulation of 25-hydroxyvitamin D3-1-hydroxylase in serum-free monolayer cultures of mouse kidney. Endocrinology. 110:1073.
11. 3 by isolated rat kidney cells. Proc. Natl. Acad. Sci. USA. 77:1537.
12. 3-1α-hydroxylase activity by calcium and caicitonin in renal cortex from hypophosphatemic (Hyp) mice. Endocrinology. 114:1203.
13. Warner, M. 1982. Catalytic activity of partially purified renal 25-hydroxyvitamin D hydroxylases from vitamin D-deficient and vitamin D-replete rats. J. Biol. Chem. 257:12995.
14. 3. J. Biol. Chem. 252:1421.
15. 3 in vivo and in primary cultures of chick kidney cells. J. Biol. Chem. 259:2722.
16. White, C. P., R. H. Richardson, and S. Posen. 1981. The synthesis of dihydroxylated vitamin D metabolites by human renal mitochondria. J. Clin. Endocrinol. Metab. 53:450.
17. 3 effective on intestine. J. Biol. Chem. 248:6691.
18. 3 on calcium and phosphate absorption by duodenum from intact and nephrectomized rats. Arch. Biochem. Biophys. 182:257.
19. 3. Science (Wash. DC). 183:1198.
20. 3 and its receptor in human target cells. In Vitamin D, Chemical, Biochemical, and Clinical Endocrinology of Calcium Metabolism. A. W. Norman, K. Schaefer, D. v. Herrath, H.-G. Grigoleit, editors. Walter de Gruyter & Co., Berlin. 31-36.
21. Warner, M. 1983. 25-hydroxyvitamin D hydroxlation: evidence for a dioxygenase activity of solubilized renal mitochondrial cytochrome’ P-450. J. Biol. Chem. 258:11590.
22. Fraser, D. R. 1980. Regulation of the metabolism of vitamin D. Physiol. Rev. 60:551.
23. Nakagawara, A., N. M. DeSantis, N. Nogueira, and C. F. Nathan. 1982. Lymphokines enhance the capacity of human monocytes to secrete reactive oxygen intermediates. J. Clin. Invest. 70:1042.
24. Anderson, J., C. Harper, C. E. Dent, and G. R. Philpot. 1954. Effect of cortisone on calcium metabolism in sarcoidosis. Lancet. 2:720.
25. Crystal, R. G., P. B. Bitterman, S. I. Rennard, A.J. Hance, and B. A. Keogh. 1984. Interstitial lung diseases of unknown cause. Disorders characterized by chronic inflammation of the lower respiratory tract. N. Engl. J. Med. 310:235.
26. 3: A novel immunoregulatory hormone. Science (Wash. DC). 224:1438.
27. 3 suppresses human T-helper/inducer lymphocyte activity in vitro. J. Immunol. In press.