Development of mitoxantrone

Investigational New Drugs

Volumn 3, Issue 2, 1985, Pages 85-93

  White, Richard J ^a   Durr, Frederick E ^a  

^a WYETH RESEARCH   (United States)

Author keywords

antitumor; cardiotoxicity; DNA; mitoxantrone; mode of action

Indexed keywords

1,4 BIS[2 (DIMETHYLAMINO)ETHYLAMINO]ANTHRAQUINONE; 1,4 DIHYDROXY 5,8 BIS[2 (DIMETHYLAMINO)ETHYLAMINO] 9,10 ANTHRACENEDIONE; AMETANTRONE; ANTHRACYCLINE ANTIBIOTIC AGENT; ANTINEOPLASTIC AGENT; CISPLATIN; CYCLOPHOSPHAMIDE; DNA; DOXORUBICIN; METHOTREXATE; MITOXANTRONE; UNCLASSIFIED DRUG; VINCRISTINE;

1,4 BIS[2 (DIMETHYLAMINO)ETHYLAMINO]ANTHRAQUINONE; 1,4 DIHYDROXY 5,8 BIS[2 (DIMETHYLAMINO)ETHYLAMINO] 9,10 ANTHRACENEDIONE; ADVERSE DRUG REACTION; ANIMAL EXPERIMENT; ANIMAL MODEL; BIOLOGICAL MODEL; BLOOD AND HEMOPOIETIC SYSTEM; BONE; CANCER CHEMOTHERAPY; CANCER COMBINATION CHEMOTHERAPY; CARDIOTOXICITY; CELL STRAIN ROS; CHO CELL; COLON CANCER; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DRUG ADMINISTRATION; DRUG ANALYSIS; DRUG COMPARISON; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG INTERACTION; DRUG MECHANISM; DRUG RESPONSE; DRUG SCREENING; DRUG SYNTHESIS; FEMALE GENITAL SYSTEM; HEART; HUMAN; HUMAN CELL; IN VITRO STUDY; INTOXICATION; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LARGE INTESTINE; LEUKEMIA L 1210; LEUKEMIA P 388; LEWIS CARCINOMA; MELANOMA B16; MOUSE; PREVENTION; PRIORITY JOURNAL; RESPIRATORY SYSTEM; SHORT SURVEY; STRUCTURE ACTIVITY RELATION; SUBCUTANEOUS DRUG ADMINISTRATION; THERAPY;

ANIMAL; ANTHRAQUINONES; ANTINEOPLASTIC AGENTS; CELL LINE; CHEMISTRY, PHARMACEUTICAL; COLONIC NEOPLASMS; CRICETULUS; DACTINOMYCIN; DNA; DOXORUBICIN; DRUG EVALUATION; DRUG SYNERGISM; FEMALE; HAMSTERS; HEART; HUMAN; INTERCALATING AGENTS; INTERPHASE; LEUKEMIA L1210; LEUKEMIA P388; MELANOMA; MICE; MITOXANTRONE; RNA; RNA, DOUBLE-STRANDED; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0021839134     PISSN: 01676997     EISSN: 15730646     Source Type: Journal    
DOI: 10.1007/BF00174154     Document Type: Article

References (29)

1. Antitumor agents I. 1,4-bis-(aminoalkyl-amino)-9, 10-anthracenediones
2. Experimental antitumor activity of aminoanthraquinones
3. The inhibitory effect of 1, 4-dihydroxy-5, 8-bis[[2-[(2-hydroxyethyl)amino]-ethyl] amino)-9, 10-anthracenedione dihydrochloride (CL 232, 315; NSC-301739D) on dividing and non-dividing cells in vitro
4. Effects of 9,10-anthracenedione, l,4-bis,[[2-[(2-hydroxyethyl)-amino]-ethyl] amino]-diacetate on cell survival and cell cycle progression in cultured mammalian cells
5. Comparative cytotoxicity of bisantrene, mitoxantrone, ametantrone, dihydroxyanthracenedione, dihydroxyanthracenedione diacetate, and doxorubicin on human cells in vitro
6. Differential killing efficacy of twenty antitumor drugs on proliferating and non-proliferating human tumor cells
7. Action of dihydroxyanthraquinone on cell cycle progression and survival of a variety of cultured mammalian cells
8. Primary bioassay of human tumor stem cells
9. Activity of mitoxantrone in a human tumor cloning assay
10. CL 232, 315 (NSC-301739) 1,4-dihydroxy-5,. 8-bis[[2-[(2-hydroxyethyl) amino]-ethyl] amino]9, 10-anthracenedione dihydrochloride: A novel antitumor agent
11. Interactions of a new antitumor agent, 1, 4-dihydroxy-5, 8-bis[[2-[(2-hydroxyethyl) amino]-ethyl]amino] -9, 10-anthracenedione with nucleic acids
12. Direct and indirect clastogenic activity of anthracenedione in Chinese hamster ovary cells
13. Sister chromatid exchange and chromosomal aberrations by DHAQ and related anthraquinone derivatives in Chinese hamster ovary cells
14. Cellular uptake and inhibition of DNA synthesis by dihydroxyanthraquinone and two analogues
15. Protein associated DNA single strand breaks and cytotoxicity of dihydroxyanthraquinone (DHAD); NSC-301739, in mouse L1210 leukemia cells
16. Effect of 1, 4-dihydroxy-5, 8-bis(2-(2-hyd-roxyethylamino) ethyl-amino) 9, 10-anthracenedione (dihydroxyanthraquinone) on the replication of simian virus 40 chromosome
17. DNA-binding specificity and RNA polymerase inhibitory activity of bis (aminoalkyl) anthraquinones and bis (methylthio) vinylquinone iodides
18. Comparison of the interaction of antineoplastic aminoanthraquinone analogs with DNA using competitive fluorescence polarization
19. Interactions of the antitumor agents mitoxantrone and bisantrene with deoxyribonucleic acids studied by electron microscopy
20. Antineoplastic agents. Structure-activity relationship study of bis (substituted aminoalkylamino) anthraquinones
21. Antitumor activity of mitoxantrone against murine experimental tumors: Comparative analysis against various antitumor antibiotics
22. Comparison of the antitumor activity of CL 232, 315, a novel aminoanthraquinone, with standard anticancer agents
23. Chemotherapy of transplantable mouse colon tumors
24. The response to chemotherapy of human breast tumor xenografts
25. Inhibition of Adriamycin-stimulated microsomal lipid peroxidation by mitoxantrone and ametantrone, two new anthracenedione antineoplastic agents
26. Differential effects of anthracycline drugs on rat heart and liver microsomal reduced nicotinamide adenine dinucleotide phosphate-dependent lipid peroxidation
27. Anthracycline cardiomyopathy monitored by morphologic changes
28. Safety assessment of a new anticancer compound, mitoxantrone, in beagle dogs: Comparison with doxorubicin. I. Clinical observations
29. Safety assessment of a new anticancer compound mitoxantrone, in beagle dogs: Comparison with doxorubicin. II. Histologic and ultrastructural pathology