Aldose Reductase Inhibitors: A Potential New Class of Agents for the Pharmacological Control of Certain Diabetic Complications

Journal of Medicinal Chemistry

Volumn 28, Issue 7, 1985, Pages 841-849

  Kador, Peter F ^a   Kinoshita, Jin H ^a   Sharpless, Norman E ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 FLUOROSPIRO[FLUORENE 9,4' IMIDAZOLIDINE] 2',5' DIONE; 2 METHYLSORBINIL; ALDEHYDE REDUCTASE; ALDOSE REDUCTASE INHIBITOR; ALLOXAN; ALRESTATIN; EPALRESTAT; FLAVONOID; GALACTOSE; HYDANTOIN; PONALRESTAT; QUERCETIN; QUERCITRIN; SORBINIL; TETRAMETHYLENEGLUTARIC ACID; TOLRESTAT;

4 NITROBENZENESULFONYL FLUORIDE; 7 HYDROXY 4 OXO 4H CHROMENE 2 CARBOXYLIC ACID; 7 HYDROXY 4 OXO 4H CHROMENE 2 CARBOXYLIC ACID ESTER; ANIMAL CELL; ANIMAL EXPERIMENT; BIOLOGICAL MODEL; CATARACT; DIABETES MELLITUS; DRUG COMPARISON; DRUG EFFICACY; DRUG INHIBITION; DRUG INTERACTION; DRUG MECHANISM; DRUG PURIFICATION; DRUG SCREENING; ENDOCRINE SYSTEM; ETIOLOGY; FEMALE GENITAL SYSTEM; HUMAN; HUMAN CELL; KERATOPATHY; KIDNEY; KIDNEY DISEASE; MICROANGIOPATHY; NERVOUS SYSTEM; NEUROPATHY; ORAL DRUG ADMINISTRATION; PERIPHERAL VASCULAR SYSTEM; PHARMACOLOGY; PREVENTION; PRIORITY JOURNAL; RAT; SHORT SURVEY; STRUCTURE ACTIVITY RELATION; THERAPY; TOLRESTAT DERIVATIVE; VISUAL SYSTEM;

ALDEHYDE REDUCTASE; ANIMAL; BINDING SITES; BLOOD GLUCOSE; CATARACT; CHEMISTRY; CORNEAL DISEASES; DIABETES MELLITUS; DIABETIC ANGIOPATHIES; DIABETIC NEPHROPATHIES; DIABETIC NEUROPATHIES; DIABETIC RETINOPATHY; DISEASE MODELS, ANIMAL; FLUORENES; GALACTOSE; HUMAN; HYDANTOINS; IMIDAZOLES; MODELS, MOLECULAR; NAPHTHALENES; PHTHALAZINES; RHODANINE; SORBITOL; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; SUGAR ALCOHOL DEHYDROGENASES; TISSUE DISTRIBUTION;

EID: 0021828899     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00145a001     Document Type: Article

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