Synthesis of the Antileukemic Agents 5, 10-Dideazaaminopterin and 5, 10-Dideaza-5, 6, 7, 8-tetrahydroaminopterin

Journal of Medicinal Chemistry

Volumn 28, Issue 7, 1985, Pages 914-921

  Taylor, Edward C ^a   Harrington, Peter J ^a   Fletcher, Stephen R ^a   Beardsley, G Peter ^b   Moran, Richard G ^c  

^a PRINCETON UNIVERSITY   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c CHILDREN S HOSPITAL LOS ANGELES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5,10 DIDEAZAAMINOPTERIN; 5,6,7,8 TETRAHYDRO 5,10 DIDEAZAAMINOPTERIN; AMINOPTERIN; DIHYDROFOLATE REDUCTASE; FOLYLPOLYGLUTAMATE SYNTHASE; METHOTREXATE; TETRAHYDROAMINOPTERIN; THYMIDYLATE SYNTHASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD AND HEMOPOIETIC SYSTEM; CANCER CHEMOTHERAPY; CATTLE; DRUG ANALYSIS; DRUG COMPARISON; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; IN VITRO STUDY; INFRARED SPECTROMETRY; INTRAPERITONEAL DRUG ADMINISTRATION; LACTOBACILLUS CASEI; LEUKEMIA L 1210; LIVER; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; THERAPY;

AMIDE SYNTHASES; AMINOPTERIN; ANIMALS; CHEMISTRY; FOLIC ACID; FOLIC ACID ANTAGONISTS; LEUKEMIA; LEUKEMIA L1210; LIGASES; MALE; METHOTREXATE; TETRAHYDROFOLATES; THYMIDYLATE SYNTHASE;

EID: 0021813844     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00145a012     Document Type: Article

References (18)

1. We are indebted to the National Cancer Institute, National Institutes of Health (Grant RO1 CA 28351) for support of this work.
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