Reversible Adrenal Insufficiency Induced by Ketoconazole

JAMA: The Journal of the American Medical Association

Volumn 253, Issue 16, 1985, Pages 2413-2414

  Tucker, W Stuart ^a,c   Snell, Barbara B ^b   Island, Donald P ^a   Gregg, Clark R ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Divisions of Endocrinology and Infectious Diseases Department of Medicine Vanderbilt University School of Medicine ^*  (United States)

^c Nalle Clinic   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROCHLOROTHIAZIDE; HYDROCHLOROTHIAZIDE PLUS TRIAMTERENE; KETOCONAZOLE; METHYLDOPA; METYRAPONE; TETRACOSACTIDE; TRIAMTERENE;

ADRENAL CORTEX INSUFFICIENCY; ADVERSE DRUG REACTION; BLASTOMYCOSIS; CASE REPORT; DRUG INDUCED DISEASE; DRUG THERAPY; ENDOCRINE SYSTEM; FUNGUS; HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RESPIRATORY SYSTEM; THERAPY;

17-HYDROXYCORTICOSTEROIDS; ADRENAL GLAND HYPOFUNCTION; CASE REPORT; CORTODOXONE; COSYNTROPIN; HUMAN; HYDROCORTISONE; KETOCONAZOLE; MALE; METYRAPONE; MIDDLE AGE;

EID: 0021813750     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.1985.03350400097029     Document Type: Article

References (11)

1. Pont A, Williams PL, Loose DS, et al.: Ketoconazole blocks adrenal steroid synthesis. Ann Intern Med 1982;97:370-372.
2. Pont A, Williams PL, Azhar S, et al.: Ketoconazole blocks testosterone synthesis. Arch Intern Med 1982;142:2137-2140.
3. Pont A, Graybill JR, Craven PC, et al.: High-dose ketoconazole therapy and adrenal and testicular function in humans. Arch Intern Med 1984;144:2150-2153.
4. Schurmeyer T, Nieschlag E: Ketoconazoleinduced drop in serum and saliva testosterone. Lancet 1982;2:1098.
5. Santen RJ, Brugmans J, Symoens J, et al.: Ketoconazole inhibits androgen production by blocking the 17-hydroxyprogesterone aldolase (C17-20 lyase) enzyme, abstracted. Clin Res 1983;31:473A.
6. Graybill JR: Summary: Potential and problems with ketoconazole. Am J Med 1983;74:86-90.
7. Baxter JD, Tyrrell JB: The adrenal cortex, in Felig P, Baxter JD, Broadus AE, et al. (eds): Endocrinology and Metabolism. New York, McGraw-Hill Book Co, 1981, p 443.
8. Rose LI, Williams GH, Jagger PI, et al.: The 48-hour adrenocorticotrophin infusion test for adrenocortical insufficiency. Ann Intern Med 1970;73:49-54.
9. Liddle GW: The adrenals, in Williams RH (ed): Textbook of Endocrinology, ed 6. Philadelphia, WB Saunders Co, 1981, pp 264-265.
10. Kowal J: The effects of ketoconazole on steroidogenesis in cultured mouse adrenal cortex tumor cells. Endocrinology 1983;112:1541-1543.
11. Loose DS, Kan PB, Hirst MA, et al.: Ketoconazole blocks adrenal steroidogenesis by inhibiting cytochrome P450-dependent enzymes. J Clin Invest 1983;71:1495-1499.