4-Deoxypyrido[1‘, 2’:1, 2]imidazo[5, 4-c]rifamycin SV Derivatives. A New Series of Semisynthetic Rifamycins with High Antibacterial Activity and Low Gastroenteric Absorption

Journal of Medicinal Chemistry

Volumn 28, Issue 7, 1985, Pages 960-963

  Brufani, Mario ^a   Cellai, Luciano ^b   Marchi, Egidio ^c   Montecchi, Laura ^c   Venturini, Anna Paola ^c   Mascellani, Giuseppe ^d  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b CNR   (Italy)

^c Alfa Wassermann SpA   (Italy)

^d Opocrin SpA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

4 DEOXYPYRIDO[1',2':1,2]IMIDAZO[5,4 C]RIFAMYCIN SV DERIVATIVE; ANTIINFECTIVE AGENT; DNA DIRECTED RNA POLYMERASE; NEW DRUG; RIFAMPICIN; RNA POLYMERASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIUM; DIGESTIVE SYSTEM; DRUG ABSORPTION; DRUG ANALYSIS; DRUG COMPARISON; DRUG IDENTIFICATION; DRUG SCREENING; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; GASTROINTESTINAL ABSORPTION; IN VITRO STUDY; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION; SUBCUTANEOUS DRUG ADMINISTRATION; THERAPY;

ANIMALS; BACTERIAL INFECTIONS; CELL WALL; CHEMISTRY; DIGESTIVE SYSTEM; INTESTINAL ABSORPTION; MICE; RATS; RIFAMYCINS; STAPHYLOCOCCAL INFECTIONS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0021797094     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00145a020     Document Type: Article

References (19)

1. Sensi, P.; Timbal, M. T.; Maffii, G. Experientia 1960, 16, 412.
2. Maggi, G.; Pasqualucci, C. R.; Ballotta, R.; Sensi, P. Chemotherapia 1966, 11, 285.
3. Bergamini, M.; Fowst, G. Arzneim.-Forsch. 1965, 15, 951.
4. Binda, G.; Domenichini, E.; Gottardi, A.; Orlandi, B.; Ortelli, E.; Pacini, B.; Fowst, G. Arzneim-Forsch. 1971, 21, 1907.
5. Brufani, M. In “Topics in Antibiotic Chemistry”; Sammes, P.G., Ed.; Ellis Horwood Ltd: Chichester, 1977; Vol. 1, pp 91–217 and references cited therein,
6. Shore, P. A.; Brodie, B. B.; Hogben, C. A. M. J. Pharmacol. Exp. Ther. 1957, 119, 361.
7. Oppolzer, W.; Prelog, V.; Sensi, P. Experientia 1964, 20, 336.
8. Furesz, S.; Timbal, M. T. Chemotherapia 1963, 7, 200.
9. Bellomo, P.; Marchi, E.; Mascellani, E.; Brufani, M. J. Med. Chem. 1981, 24, 1310.
10. Dampier, M. F.; Chen, C.-W.; Whitlock, H. W., Jr. J. Am. Chem. Soc. 1976, 98, 7064.
11. Chamberlin, M. In “The Enzymes. Bacterial DNA-dependent RNA polymerase”; Boyer, P. D., Ed.; Academic Press: New York, 1974; Vol. 10, p 333.
12. Mosby, W. L.; Boyle, R. J. J. Org. Chem. 1959, 24, 374.
13. Brufani, M.; Cellai, L.; Cerrini, S.; Fedeli, W.; Marchi, E.; Segre, A.; Vaciago, A. J. Antibiot. 1984, 37, 1623.
14. Venturini, A. P. Chemotherapy 1983, 29, 1.
15. Cellai, L.; Colosimo, M.; Marchi, E. J. Labelled Compd. Radiopharm. 1983, 20, 1287.
16. Cellai, L.; Colosimo, M.; Marchi, E.; Venturini, A. P.; Zanolo, G. Chemiotherapia 1984, 3, 373.
17. Biagi, G. L.; Barbaro, A. M.; Gamba, M. F.; Guerra, M. C. J. Chromatogr. 1969, 41, 371.
18. Sensi, P.; Greco, M. A.; Furesz, S.; Maffi, G. Antimicrob. Agents Chemother. 1966, 699.
19. Reed, L. J.; Muench, H. Am. J. Hygiene 1938, 27, 493.