Inhibition by ketanserin of serotonin induced cerebral arteriolar constriction

Stroke

Volumn 15, Issue 6, 1984, Pages 1021-1024

  Thompson, James A ^a   Wei, Enoch P ^a   Kontos, Hermes A ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

KETANSERIN; SEROTONIN;

ANIMAL CELL; ANIMAL EXPERIMENT; CAT; CENTRAL NERVOUS SYSTEM; DRUG ANTAGONISM; NONHUMAN; OCCLUSIVE CEREBROVASCULAR DISEASE; PERIPHERAL VASCULAR SYSTEM; PIA ARTERIOLE; PRIORITY JOURNAL;

ANIMAL; ARTERIOLES; CATS; CEREBRAL ARTERIES; KETANSERIN; MICROCIRCULATION; PIA MATER; PIPERIDINES; PLATELET AGGREGATION; RECEPTORS, SEROTONIN; SEROTONIN; SEROTONIN ANTAGONISTS; SUPPORT, U.S. GOV'T, P.H.S.; VASOCONSTRICTION;

EID: 0021740052     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/01.STR.15.6.1021     Document Type: Article

References (14)

1. Edvinsson L, Mackenzie ET: Amine mechanisms in the cerebral circulation. Pharmacol Rev 28: 275-348, 1976
2. Edvinsson L, Hardebo JE, Owman C: Pharmacological analysis of 5-hydroxytryptamine receptors in isolated intracranial and extra-cranial vessels of cat and man. Circ Res 42: 143-151, 1978
3. Rosenblum WI. Pial arteriolar responses in the mouse brain revisited Stroke 7: 283-287, 1976
4. Harper AM, Mackenzie ET: Effects of 5-hydroxytryptamine on pial arteriolar calibre in anesthetized cats. J Physiol (London) 271: 735-746, 1977
5. Harper MA, Mackenzie ET. Cerebral circulatory and metabolic effects of 5-hydroxytryptamine in anaesthetized baboons. J Physiol (London) 271: 721-733, 1977
6. Peroutka SH, Lebovitz RM, Synder SH: Two distinct central serotonin receptors with different physiological functions. Science 212: 828-829, 1981
7. Cohen ML, Fuller RW, Wiley KS: Evidence of 5-HT2 receptors mediating contraction in vascular smooth muscle. J Pharmacol Exp Ther 218: 421-425, 1981
8. Leysen JE, Niemegeers CJE, Van Nueton JM, Laduron PM: 3H-ketanserin (R41 468) a selective 3H-ligand for serotonin (S2)-receptor binding sites: Binding properties, brain distribution and functional role. Mol Pharmacol 21: 301-314, 1982
9. Lavasseur JE, Wei EP, Raper AJ, Kontos HA, Patterson JL: Detailed description of a cranial window technique for acute and chronic experiments. Stroke 6: 308-314, 1975
10. Wei EP, Kontos HA, Patterson JL: Dependence of pial arteriolar response to hypercapnia on vessel size. Am J Physiol 238: 697- 703, 1980
11. Wei EP, Raper AJ, Kontos HA, Patterson JL: Determinants of response of pial arteries to norepinephrine and sympathetic nerve stimulation. Stroke 6: 654-658, 1975
12. SAS Institute Inc: In SAS User’s Guide: Statistics PROM GLM, Cary, N.C.: SAS Institute Inc., 139-201, 1982
13. 2. Stroke 8: 480-483, 1977
14. Kontos HA, Wei EP, Ellis EF, Dietrich WD, Povlishock JT: Pros-taglandins in physiological and in certain pathological responses of the cerebral circulation. Fed Proc 40: 2326-2330, 1981