Pargyline and deprenyl prevent the neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in monkeys

European Journal of Pharmacology

Volumn 106, Issue 1, 1984, Pages 209-210

  Cohen, Gerald ^a   Pasik, Pedro ^a   Cohen, Bernard ^a   Leist, Andres ^a   Mytilineou, Catherine ^a   Yahr, Melvin D ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; DOPAMINE H 3; PARGYLINE; RADIOISOTOPE; SELEGILINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CAUDATE NUCLEUS; CENTRAL NERVOUS SYSTEM; DRUG ANTAGONISM; DRUG RECEPTOR BINDING; INTOXICATION; MONKEY; NERVOUS SYSTEM; NEUROTOXICITY; NONHUMAN; PARKINSONISM; PHARMACOKINETICS; PRIORITY JOURNAL;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; ANIMALS; CAUDATE NUCLEUS; DOPAMINE; FEMALE; HOMOVANILLIC ACID; MACACA FASCICULARIS; PARGYLINE; PARKINSON DISEASE, SECONDARY; PHENETHYLAMINES; PYRIDINES; SELEGILINE;

EID: 0021712735     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(84)90700-3     Document Type: Article

References (5)

1. A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
2. Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase
3. The pathobiology of Parkinson's disease: biochemical aspects of dopamine neuron senescence
4. Chronic parkinsonism in humans due to a product of meperidine-analog synthesis
5. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine destroys dopamine neurons in explants of embryonic rat substantia nigra