Decreased endothelium-dependent relaxation in New Zealand genetic hypertensive rats

Journal of Hypertension

Volumn 2, Issue 5, 1984, Pages 541-545

  Winquist, Raymond J ^a   Bunting, Patricia B ^a   Baskin, Elizabeth P ^a   Wallace, Audrey A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

A23187; Acetylcholine; Endothelial relaxant factor; Sodium nitroprusside; Vasodilator responsiveness

Indexed keywords

ACETYLCHOLINE; NITROPRUSSIDE SODIUM;

ANIMAL CELL; AORTA; CARDIOVASCULAR SYSTEM; ENDOTHELIUM; ETIOLOGY; GREAT BLOOD VESSEL; HEREDITY; HYPERTENSION; INHERITANCE; NONHUMAN; RAT; VASODILATATION;

ACETYLCHOLINE; ANIMAL; AORTA; CALCIMYCIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM; HYPERTENSION; METHOXAMINE; MUSCLE CONTRACTION; NITROPRUSSIDE; RATS; RATS, INBRED SHR; VASODILATION;

EID: 0021705651     PISSN: 02636352     EISSN: 14735598     Source Type: Journal    
DOI: 10.1097/00004872-198410000-00015     Document Type: Article

References (28)

1. Furchgott RF, Zawadski JV: The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980, 288:273-276.
2. De Mey JG, Vanhoutte PM: Role of the intima in cholinergic and purinergic relaxation of isolated canine femoral arteries. J Physiol (Lond) 1981, 316:347-355.
3. Altura BM, Chand N: Bradykinin-induced relaxation of renal and pulmonary arteries is dependent upon intact endothelial cells. Br J Pharmacol 1981, 74:10-11.
4. Van de Voorde J, Leusen I: Vascular endothelium and the relaxant effect of histamine on aorta of the rat. Arch Int Pharmacodyn 1982, 256:329-330.
5. Furchgott RF, Zawadski JV, Cherry PD: Role of endothelium in the vasodilator response to acetylcholine. In Vasodilatation edited by Vanhoutte PM, Leusen I, New York: Raven Press, 1981, pp 49-66.
6. Angus JA, Campbell GR, Cocks TM, Manderson JA: Vasodilatation by acetylcholine is endothelium-dependent: a study by sonomicrometry in canine femoral artery in vivo. J Physiol (Lond) 1983, 344:209-222.
7. Vanhoutte PM: Why is acetylcholine a vasodilator? In Vasodilatation edited by Vanhoutte PM, Leusen I, New York: Raven Press, 1981, pp 67-72.
8. Wei EP, Dietrich WD, Povlishock JT, Navari JT, Kontos HA: Functional, morphological, and metabolic abnormalities of the cerebral microcirculation after concussive brain injury in cats. Circ Res 1980, 46:37-47.
9. Limas C, Westrum B, Limas CJ, Cohn JN: Effect of salt on the vascular lesions of spontaneously hypertensive rats. Hypertension 1980, 2:477-489.
10. Hazama F, Amano S, Ozaki T: Pathological changes of cerebral vessel endothelial cells in spontaneously hypertensive rats, with special reference to the role of these cells in the development of hypertensive cerebrovascular lesions. Adv Neurol 1978, 20:359-369.
11. Boyd GW: The pathophysiology of chronic arterial hyper-tension: a hypothesis. Clin Exp Pharmacol Physiol 1980, 7:541-544.
12. Shibata S, Cheng JB: Vascular relaxation in hypertensive rats. In Mechanisms of Vasodilatation edited by Vanhoutte PM, Basel: Karger, 1978, pp 181-186.
13. Cauvin C, Pegram B: Decreased relaxation of isolated mesenteric resistance vessels from two-kidney, one-clip Goldblatt hypertensive rats. Clin Exp Hypertension 1983, A5:383-400.
14. Konishi M, Su C: Role of endothelium in dilator responses of spontaneously hypertensive rat arteries. Hypertension 1983, 5:881-886.
15. Rapoport RM, Murad F: Agonist-induced endothelium-dependent relaxation in rat thoracic aorta may be mediated through cGMP. Circ Res 1983, 52:352-357.
16. Rapoport RM, Draznin MB, Murad F: Endothelium-dependent relaxation in rat aorta may be mediated through cyclic GMP-dependent protein phosphorylation. Nature 1983, 306:174-176.
17. Furchgott RF: The requirement for endothelial cells in the relaxation of arteries by acetylcholine and some other vasodilators. Trends in Pharmacol Sci 1981, 2:173-176.
18. Winquist RJ, Webb RC, Bohr DF: Vascular smooth muscle in hypertension. Fed Proc 1982, 41:2387-2393.
19. Cohen ML, Berkowitz BA: Decreased vascular relaxation in hypertension. J Pharmacol Exp Ther 1976, 196:396-406.
20. Antonaccio MJ, Cavaliere T, Cote D: Ontogenesis of hypertension and responsiveness to antihypertensive agents in spontaneously hypertensive rats. Blood Vessels 1980, 17:78-90.
21. Cohen DM, Webb RC, Bohr DF: Nitroprusside-induced vascular relaxation in DOCA hypertensive rats. Hypertension 1982, 4:13-19.
22. Bevan JA, Pegram BL, Prehn JL, Winquist RJ: b-adrenergic receptor-mediated vasodilatation. In Mechanisms of Vasodilatation edited by Vanhoutte PM, Leusen I, Basel: Karger, 1978, pp 258-265.
23. Cohen ML, Berkowitz BA: Age-related changes in vascular responsiveness to cyclic nucleotides and contractile agonists. J Pharmacol Exp Ther 1974, 191:147-155.
24. Bevan JA, Bevan RD, Duckies SP: Adrenergic regulation of vascular smooth muscle. In Handbook of Physiology, Section 2: Cardiovascular System, Volume II, Vascular Smooth Muscle, edited by Bohr DF, Somlyo AP, Sparks HV Jr. Bethesda: American Physiological Society, 1980, pp 515-566.
25. Fleisch JH, Maling HM, Brodie BB: Beta-receptor activity in aorta: variation with age and species. Circ Res 1970, 26:151-162.
26. Winquist RJ, Bohr DF: Structural and functional changes in cerebral arteries from spontaneously hypertensive rats. Hypertension 1983, 5:292-297.
27. Fink G D, Brody MJ: Renal vascular resistance and reactivity in two forms of genetic hypertension in the rat. Jpn Heart J 1979, 20 (suppl I): 71-72.
28. Hollenberg NK, Adams DF: The renal circulation in hypertensive disease. Am J Med 1976, 60:773-784.