Chymopapain for the treatment of intervertebral disc herniation the final report of a double-blind study

Spine

Volumn 9, Issue 8, 1984, Pages 815-818

  Fraser, Robert D ^a  

^a FLINDERS MEDICAL CENTRE   (Australia)

Author keywords

Chymopapain; Intervertebral disc herniation; Saline

Indexed keywords

ANALGESIC AGENT; CHYMOPAPAIN; METRIZAMIDE; PLACEBO;

CENTRAL NERVOUS SYSTEM; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; DRUG THERAPY; HUMAN; INTERVERTEBRAL DISK HERNIA; INTRATHECAL DRUG ADMINISTRATION; PRIORITY JOURNAL; THERAPY;

ANALGESICS; CHYMOPAPAIN; DOUBLE-BLIND METHOD; DRUG EVALUATION; ENDOPEPTIDASES; FOLLOW-UP STUDIES; HUMAN; INTERVERTEBRAL DISK DISPLACEMENT; LUMBAR VERTEBRAE; RANDOM ALLOCATION; SCIATICA;

EID: 0021703986     PISSN: 03622436     EISSN: 15281159     Source Type: Journal    
DOI: 10.1097/00007632-198411000-00008     Document Type: Article

References (22)

1. Benoist M, Deburge A, Heripret G, et al: Treatment of lumbar disc herniation by chymopapain chemonucleolysis: A report on 120 patients. Spine 7:613-617, 1982
2. Bradford DS, Oegema TR, Cooper KM: Chymopapain, chemonucleolysis and nucleus pulposus regeneration. A biochemical and biomechanical study. Presented at the annual meeting of the International Society for the Study of the Lumbar Spine, Cambridge, England, April 6, 1983
3. Brodsky AE, Binder WF: Lumbar discography. Its value in diagnosis and treatment of lumbar disc lesions. Spine 4:110-120, 1979
4. Collis JS, Gardner WJ: Lumbar discography: an analysis of one thousand cases. J Neurosurg 19:452-461, 1962
5. Fraser RD: Chymopapain for the treatment of intervertebral disc herniation: A preliminary report of a double-blind study. Spine 7:608-612, 1982
6. Ford LT: Clinical use of chymopapain in lumbar and dorsal disk lesions: An end-result study. Clin Orthop 67:81-87, 1969
7. Garvin PJ, Jennings RB: Long-term effects of chymopapain on intervertebral discs of dogs. Clin Orthop 92:281-295, 1973
8. Gresham JL, Miller R: Evaluationofthelumbarspinebydiskography and its use in selection of proper treatment of the herniated disk syndrome. Clin Orthop 67:29-41, 1969
9. Leavitt F, Garrón DC, Whisler WW, D’Angelo CM: A comparison of patients treated by chymopapain and laminectomy for low back pain using a multi-dimensional pain scale. Clin Orthop 146:136-143, 1980
10. McCulloch JA: Chemonucleolysis: Experience with 2,000 cases. Clin Orthop 146:128-135, 1980
11. McCulloch JA, Waddell G: Lateral lumbar discography. Br J Radiol 51:498-502, 1978
12. Macnab I, McCuIloch JA, Weiner DS, et al: Chemonucleolysis. Can J Surg 14:280-289, 1971
13. Massie WK, Stevens DB: A critical evaluation of discography. J Bone Joint Surg 49A: 1243-1244, 1967
14. Morris J, Stromberg L: Double-blind study of Disease (chymopapain) versus C.E.I. (chymopapain activator) in the treatment of herniated nucleus pulposus in the lumbar spine. Presented at the annual meeting of the International Society for the Study of the Lumbar Spine, Cambridge, England, April 9, 1983
15. Nordby E, Javid MJ, Ford LT, et al: Studies of a refined form of chymopapain (Chymodiactin) R. Presented at the annual meeting of the International Society for the Study of the Lumbar Spine, Cambridge, England, April 9, 1983
16. Nordby EJ, Lucas GL: A comparative analysis of lumbar disk disease treated by laminectomy or chemonucleolysis. Clin Orthop 90:119-129, 1973
17. Onofrio BM: Injection of chymopapain into intervertebral discs: Preliminary report on 72 patients with symptoms of disc disease. J Neurosurg 42:384-388, 1975
18. Parkinson D, Shields C: Treatment of protruded lumbar intervertebral discs with chymopapain (Disease). J Neurosurg 39:203-208, 1973
19. Ravichandran G, Mulholland RC: Chymopapain chemonucleolysis. A preliminary report. Spine 5:380-384, 1980.
20. Smith L, Brown JE: Treatment of lumbar intervertebral disc lesions by direct injection of chymopapain. J Bone Joint Surg 49B:502-519,1967
21. Wakano K, Kasman R, Chao EY, Bradford DS, Oegema TR: Biomechanical analysis of canine intervertebral discs after chymopapain injection: A preliminary report. Spine 8:59-68, 1983
22. Wiltse LL, Widell EH, Yuan HA: Chymopapain chemonucleolysis in lumbar disk disease. JAMA 231:474-479, 1975