Association of Respiratory Viral Infections with Pulmonary Deterioration in Patients with Cystic Fibrosis

New England Journal of Medicine

Volumn 311, Issue 26, 1984, Pages 1653-1658

  Wang, Elaine E L ^a   Prober, Charles G ^a   Manson, Barbara ^a   Corey, Mary ^a   Levison, Henry ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CHILD; CONGENITAL DISORDER; CONTROLLED STUDY; CYSTIC FIBROSIS; DIAGNOSIS; HUMAN; HUMAN RHINOVIRUS; INFLUENZA VIRUS; LUNG FUNCTION TEST; PARAMYXOVIRUS; PRIORITY JOURNAL; PROSPECTIVE STUDY; RESPIRATORY SYSTEM; VIRAL RESPIRATORY TRACT INFECTION; VIRUS INFECTION;

EID: 0021687443     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM198412273112602     Document Type: Article

References (45)

1. Cystic Fibrosis Foundation. Report of the patient registry, 1977:21. Rockville, Md.: Cystic Fibrosis Foundation, 1979.
2. Gurwitz D, Corey M, Francis PWJ, Crozier D, Levinson H. Perspectives in cystic fibrosis. Pediatr Clin North Am 1979; 26: 603–15.
3. Smith AL. Antibiotic therapy — efficacy and assessment: perspectives in cystic fibrosis. Presented at the Eighth International Cystic Fibrosis Congress, Toronto, Canada, May 26–30, 1980.
4. Wientzen R, Prestidge CB, Kramer RI, McCracken GH, Nelson JD. Acute pulmonary exacerbations in cystic fibrosis: a double-blind trial of tobramycin and placebo therapy. Am J Dis Child 1980; 134: 1134–8.
5. Hyattachéal, Chipps BE, Kumor KM, Mellits ED, Lietman PS, Rosenstein BJ. A double-blind controlled trial of anti-Pseudomonas chemotherapy of acute respiratory exacerbations in patients with cystic fibrosis. J Pediatr 1981; 99: 307–11.
6. Beaudry PH, Marks MI, McDougall D, Desmond K, Rangel R. Is anti-Pseudomonas therapy warranted in acute respiratory exacerbations in children with cystic fibrosis? J Pediatr 1980; 97: 144–7.
7. McLaughlin FJ, Matthews WJ Jr, Strieder DJ, et al. Clinical and bacteriological responses to three antibiotic regimens for acute exacerbations of cystic fibrosis: ticarcillin-tobramycin, azlocillin-tobramycin, and azlocillin-placebo. J Infect Dis 1983; 147: 559–67.
8. Minor TE, Baker JW, Dick EC, et al. Greater frequency of viral respiratory infections in asthmatic children as compared with their nonasthmatic siblings. J Pediatr 1974; 85: 472–7.
9. McIntosh K, Ellis EF, Hoffman LS, Lybass TG, Eller JJ, Fulginiti VA. The association of viral and bacterial respiratory infections with exacerbations of wheezing in young asthmatic children. J Pediatr 1973; 82: 578–90.
10. Berkovich S, Millian SJ, Snyder RD. The association of viral and mycoplasma infection with occurrence of wheezing in the asthmatic child. Ann Allergy 1970; 28: 43–9.
11. Huhti E, Mokka T, Nikoskelainen J, Halonen P. Association of viral and mycoplasma infections with exacerbations of asthma. Ann Allergy 1974; 33: 145–9.
12. Carilli AD, Gohd RS, Gordon W. A virologic study of chronic bronchitis. N Engl J Med 1974; 270: 123–7.
13. Buscho RO, Saxtan D, Schultz PS, Finch E, Mufson MA. Infections with viruses and Mycoplasma pneumoniae during exacerbations of chronic bronchitis. J Infect Dis 1978; 137: 377–83.
14. McNamara MJ, Phillips IA, Williams OB. Viral and Mycoplasma pneumoniae infections in exacerbations of chronic lung disease. Am Rev Respir Dis 1969; 100: 19–24.
15. Smith CB, Golden C, Klauber MR, Kanner R, Renzetti A. Interactions between viruses and bacteria in patients with chronic bronchitis. J Infect Dis 1976; 134: 552–61.
16. Eadie MB, Stott EJ, Grist NR. Virological studies in chronic bronchitis. Br Med J 1966; 2: 671–3.
17. Lamy ME, Pouthier-Simon F, Debacker-Willame E. Respiratory viral infections in hospital patients with chronic bronchitis: observations during periods of exacerbation and quiescence. Chest 1973; 63: 336–41.
18. Gump DW, Phillips CA, Forsyth BR, McIntosh K, Lamborn KR, Stouch WH. Role of infection in chronic bronchitis. Am Rev Respir Dis 1976; 113: 465–74.
19. Smith CB, Golden CA, Kanner RE, Renzetti AD Jr. Association of viral and Mycoplasma pneumoniae infections with acute respiratory illness in patients with chronic obstructive pulmonary diseases. Am Rev Respir Dis 1980; 121: 225–32.
20. Smith CB, Kanner RE, Golden CA, Klauber MR, Renzetti AD Jr. Effect of viral infections on pulmonary function in patients with chronic obstructive pulmonary diseases. J Infect Dis 1980; 141: 271–80.
21. Green GM, Jakab GJ, Low RB, Davis GS. Defense mechanisms of the respiratory membrane. Am Rev Respir Dis 1977; 115: 479–514.
22. Jakab GJ, Green GM. Pulmonary defense mechanisms in consolidated and nonconsolidated regions of lungs infected with Sendai virus. J Infect Dis 1974; 129: 263–70.
23. Jakab. Defect in intracellular killing of Staphylococcus aureus within alveolar macrophages in Sendai virus-infected murine lungs. J Clin Invest 1976; 57: 1533–9.
24. Fainstein V, Musher DM, Cate TR. Bacterial adherence to pharyngeal cells during viral infection. J Infect Dis 1980; 141: 172–6.
25. Wright PF, Khaw KT, Oxman MN, Shwachman H. Evaluation of the safety of amantadine · HCL and the role of respiratory viral infections in children with cystic fibrosis. J Infect Dis 1976; 134: 144–9.
26. Petersen NT, Høiby N, Mordhorst CH, Lind K, Flensburg EW, Bruun B. Respiratory infections in cystic fibrosis patients caused by virus, chlamydia and mycoplasma — possible synergism with Pseudomonas aeruginosa. Acta Paediatr Scand 1981; 70: 623–8.
27. Deforest A, Grosz HC, Laraya-Cuasay LR, Huang NN. A serologic study of Mycoplasma pneumoniae and respiratory syncytial virus infections in patients with cystic fibrosis. In: Cystic Fibrosis Club abstracts. Atlanta: Cystic Fibrosis Foundation, 1976:31.
28. Efthimiou J, Hodson ME, Taylor P, Taylor AG, Batten JC. Importance of viruses and Legionella pneumophila in respiratory exacerbations of young adults with cystic fibrosis. Thorax 1984; 39: 150–4.
29. Shwachman H, Kulczycki LL. long-term study of one hundred five patients with cystic fibrosis: studies made over a five- to fourteen-year period. Am J Dis Child 1958; 96: 6–15.
30. Brasfield D, Hicks G, Soong S, Tiller RE. The chest roentgenogram in cystic fibrosis: a new scoring system. Pediatrics 1979; 63: 24–9.
31. Featherby EA, Weng T-R, Crozier DN, Duic A, Reilly BJ, Levison H. Dynamic and static lung volumes, blood gas tensions, and diffusing capacity in patients with cystic fibrosis. Am Rev Respir Dis 1970; 102: 737–49.
32. Hall CB, Douglas RG Jr. Clinically useful method for the isolation of respiratory syncytial virus. J Infect Dis 1975; 131: 1–5.
33. Bartlett JG, Finegold SM. Bacteriology of expectorated sputum with quantitative culture and wash technique compared to transtracheal aspirates. Am Rev Respir Dis 1978; 117: 1019–27.
34. Kanner RE, Renzetti AD Jr, Klauber MR, Smith CB, Golden CA. Variables associated with changes in spirometry in patients with obstructive lung diseases. Am J Med 1979; 67: 44–50.
35. Nolan G, McIvor P, Levison H, Fleming PC, Corey M, Gold R. Antibiotic prophylaxis in cystic fibrosis: inhaled cephaloridine as an adjunct to oral cloxacillin. J Pediatr 1982; 101: 626–30.
36. Corey M, Levison H, Crozier D. Five- to seven-year course of pulmonary function in cystic fibrosis. Am Rev Respir Dis 1976; 114: 1085–92.
37. SAS user's guide: statistics. Cary, N.C.: SAS Institute, 1982.
38. Cooney MK, Fox JP, Hall CE. The Seattle Virus Watch. VI. Observations of infections with and illness due to parainfluenza, mumps and respiratory syncytial viruses and Mycoplasma pneumoniae. Am J Epidemiol 1975; 101: 532–51.
39. Tyrrell DAJ. Studies of rhinoviruses and coronaviruses at the Common Cold Unit, Salisbury, Wiltshire. Postgrad Med J 1979; 55: 117–21.
40. Cooney MK, Hall CE, Fox JP. The Seattle Virus Watch. III. Evaluation of isolation methods and summary of infections detected by virus isolations. Am J Epidemiol 1972; 96: 286–305.
41. Parrott RH, Kim HW, Brandt CD, et al. Respiratory syncytial virus. In: Lennette EH, Schmidt NJ, eds. Diagnostic procedures for viral, rickettsial and chlamydial infections. Washington, D.C.: American Public Health Association, 1979:695–708.
42. Gurwitz D, Corey M, Levison H. Pulmonary function and bronchial reactivity in children after croup. Am Rev Respir Dis 1980; 122: 95–9.
43. Kattan M, Keens TG, Lapierre J-G, Levison H, Bryan C, Reilly BJ. Pulmonary function abnormalities in symptom-free children after bronchiolitis. Pediatrics 1977; 59: 683–8.
44. Harford CG, Leidler V, Hara M. Effect of the lesion due to influenza virus on the response of mice to inhaled pneumococci. J Exp Med 1949; 89: 53–68.
45. Boxerbaum B. The art and science of the use of antibiotics in cystic fibrosis. Pediatr Infect Dis 1982; 1: 381–3.