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Volumn 44, Issue , 1984, Pages 5638-5643

Role of NADPH:Cytochrome c Reductase and DT-Diaphorase in the Biotransformation of Mitomycin C

Author keywords

[No Author keywords available]

Indexed keywords

MITOMYCIN C; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE;

EID: 0021687360     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (206)

References (34)
  • 2
    • 0014389169 scopus 로고
    • Mitomycin C (NSC-26980)--clinical brochure
    • Carter, S. K. Mitomycin C (NSC-26980)--clinical brochure. Cancer Chemother. Rep. Part lll, 7; 99-144, 1968.
    • (1968) Cancer Chemother. Rep. Part lll , vol.7 , pp. 99-144
    • Carter, S.K.1
  • 3
    • 0015511932 scopus 로고
    • Kinetic parameters of drug-metabolizing enzymes in Ca2+-sedimented microsomes from rat liver
    • Cinti, D. L., Moldeus, P., and Schenkman, J. B. Kinetic parameters of drug-metabolizing enzymes in Ca2+-sedimented microsomes from rat liver. Biochem. Pharmacol., 21: 3249-3256, 1972.
    • (1972) Biochem. Pharmacol. , vol.21 , pp. 3249-3256
    • Cinti, D.L.1    Moldeus, P.2    Schenkman, J.B.3
  • 4
    • 0017833010 scopus 로고
    • Two forms of liver microsomal cytochrome P-450, P-450lm2 and P-450lmm (rabbit liver)
    • Coon, M. S., van der Hoeven, T. A., Dahl, S. B., and Haugen, D. A. Two forms of liver microsomal cytochrome P-450, P-450lm2 and P-450lmm (rabbit liver). Methods Enzymol., 52: 109-117, 1978.
    • (1978) Methods Enzymol. , vol.52 , pp. 109-117
    • Coon, M.S.1    van der Hoeven, T.A.2    Dahl, S.B.3    Haugen, D.A.4
  • 6
    • 77957000392 scopus 로고
    • DT-diaphorase
    • Emster, L. DT-diaphorase. Methods Enzymol., 10: 309-317, 1967.
    • (1967) Methods Enzymol. , vol.10 , pp. 309-317
    • Emster, L.1
  • 7
    • 0018354912 scopus 로고
    • Properties of NADPH-cytochrome P-450 reductase purified from rabbit liver microsomes
    • French, J. S., and Coon, M. J. Properties of NADPH-cytochrome P-450 reductase purified from rabbit liver microsomes. Arch. Biochem. Blophys., 195: 565-577, 1979.
    • (1979) Arch. Biochem. Blophys. , vol.195 , pp. 565-577
    • French, J.S.1    Coon, M.J.2
  • 8
    • 70449319736 scopus 로고
    • Revised spectropho-tometric methods for the determination of glutamic-oxalacetic transaminase, glutamic-pyruvic transaminase, and lactic acid dehydrogenase
    • Henry, R. J., Chiamori, N., Golub, O. J., and Berkman, S. Revised spectropho-tometric methods for the determination of glutamic-oxalacetic transaminase, glutamic-pyruvic transaminase, and lactic acid dehydrogenase. Am. J. Clin. Pathol., 34: 381-398, 1960.
    • (1960) Am. J. Clin. Pathol. , vol.34 , pp. 381-398
    • Henry, R.J.1    Chiamori, N.2    Golub, O.J.3    Berkman, S.4
  • 9
    • 78651117965 scopus 로고
    • A molecular mechanism of mitomycin action: linking of complementary DNA strands
    • Iyer, V. N., and Szybalski, W. A molecular mechanism of mitomycin action: linking of complementary DNA strands. Proc. Nati. Acad. Sci. USA, 50: 355-362, 1963.
    • (1963) Proc. Nati. Acad. Sci. USA , vol.50 , pp. 355-362
    • Iyer, V.N.1    Szybalski, W.2
  • 10
    • 0018621589 scopus 로고
    • Thermosensitization by sulfhydryl compounds of exponentially growing Chinese hamster cells
    • Kapp, D. S., and Hahn, G. M. Thermosensitization by sulfhydryl compounds of exponentially growing Chinese hamster cells. Cancer Res., 39: 4630-4635, 1979.
    • (1979) Cancer Res. , vol.39 , pp. 4630-4635
    • Kapp, D.S.1    Hahn, G.M.2
  • 11
    • 0018852436 scopus 로고
    • A preferential activation of mitomycin C to cytotoxic metabolites by hypoxic tumor cells
    • Kennedy, K. A., Rockwell, S., and Sartorelli, A. C. A preferential activation of mitomycin C to cytotoxic metabolites by hypoxic tumor cells. Cancer Res., 40: 2356-2360, 1980.
    • (1980) Cancer Res. , vol.40 , pp. 2356-2360
    • Kennedy, K.A.1    Rockwell, S.2    Sartorelli, A.C.3
  • 12
  • 14
    • 0018573813 scopus 로고
    • Activation of mitomycin C and quinonedrug metabolism by NADPH-cytochrome P-450 reductase
    • Komiyama, T., Oki, T., and Inui, T. Activation of mitomycin C and quinonedrug metabolism by NADPH-cytochrome P-450 reductase. J. Pharm. Dyn., 2; 407-410, 1979.
    • (1979) J. Pharm. Dyn. , vol.2 , pp. 407-410
    • Komiyama, T.1    Oki, T.2    Inui, T.3
  • 15
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli, U. K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (Lond.), 227: 680-685, 1970.
    • (1970) Nature (Lond.) , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 16
    • 0018100085 scopus 로고
    • Genetic analysis of a Chinese hamster cell line lacking a Gt phase
    • Uskay, R. M. Genetic analysis of a Chinese hamster cell line lacking a Gt phase. Exp. cell Res., 114: 69-77, 1978.
    • (1978) Exp. cell Res. , vol.114 , pp. 69-77
    • Uskay, R.M.1
  • 18
    • 0019724691 scopus 로고
    • Naturally-occurring quinones as potential bioreductive alkylating agents
    • Moore, H. W., and Czemiak, R. Naturally-occurring quinones as potential bioreductive alkylating agents. Med. Res. Rev., 7: 249-280, 1981.
    • (1981) Med. Res. Rev. , vol.7 , pp. 249-280
    • Moore, H.W.1    Czemiak, R.2
  • 19
    • 0021276479 scopus 로고
    • Hypoxic fractions of solid tumors: experimental techniques, methods of analysis, and a survey of existing data
    • Moulder, J. E., and Rockwell, S. Hypoxic fractions of solid tumors: experimental techniques, methods of analysis, and a survey of existing data. Int. J. Radiat. Oncol. Biol. Phys., 70: 695-712, 1984.
    • (1984) Int. J. Radiat. Oncol. Biol. Phys. , vol.70 , pp. 695-712
    • Moulder, J.E.1    Rockwell, S.2
  • 20
    • 78651165715 scopus 로고
    • The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature
    • Omura, T., and Sato, R. The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature. J. Biol. Chem., 239: 2370-2378, 1964.
    • (1964) J. Biol. Chem. , vol.239 , pp. 2370-2378
    • Omura, T.1    Sato, R.2
  • 21
    • 0021345793 scopus 로고
    • Reductive activation of mitomycin C and mitomycin C metabolites catalyzed by NADPH-cytochrome P-450 reductase and xanthine oxidase
    • Pan, S.-S., Andrews, P. A., Glover, C. J., and Bachur, N. R. Reductive activation of mitomycin C and mitomycin C metabolites catalyzed by NADPH-cytochrome P-450 reductase and xanthine oxidase. J. Biol. Chem., 259: 959-966, 1984.
    • (1984) J. Biol. Chem. , vol.259 , pp. 959-966
    • Pan, S.-S.1    Andrews, P.A.2    Glover, C.J.3    Bachur, N.R.4
  • 22
    • 0020579590 scopus 로고
    • Involvement of FMN and phenobarbetal cytochrome P-450 in stimulating a one-electron reductive denitrosation of 1-(2-chloethyl)-3-(cyclohexyl)-1 -nitrosourea catalyzed by NADPH-cytochrome P-450 reductase
    • Potter, D. W., and Reed, D. J. Involvement of FMN and phenobarbetal cytochrome P-450 in stimulating a one-electron reductive denitrosation of 1-(2-chloethyl)-3-(cyclohexyl)-1 -nitrosourea catalyzed by NADPH-cytochrome P-450 reductase. J. Biol. Chem., 258: 6906-6911, 1983.
    • (1983) J. Biol. Chem. , vol.258 , pp. 6906-6911
    • Potter, D.W.1    Reed, D.J.2
  • 23
    • 0020556148 scopus 로고
    • Activity of mitomycin C for aerobic and hypoxic cells in vitro and in vivo
    • Rauth, A. M., Mohindra, J. K., and Tannock, I. F. Activity of mitomycin C for aerobic and hypoxic cells in vitro and in vivo. Cancer Res., 43: 4154-4158, 1983.
    • (1983) Cancer Res. , vol.43 , pp. 4154-4158
    • Rauth, A.M.1    Mohindra, J.K.2    Tannock, I.F.3
  • 24
    • 0017603563 scopus 로고
    • In vivo-in vitro tumors systems: new models for studying the response of tumors to therapy
    • Rockwell, S. In vivo-in vitro tumors systems: new models for studying the response of tumors to therapy. Lab. Anim. Sci. 27 (Part 2): 831-851, 1977.
    • (1977) Lab. Anim. Sci. , vol.27 , pp. 831-851
    • Rockwell, S.1
  • 25
    • 0021057557 scopus 로고
    • Effects of mitomycin C alone and in combination with X-rays on EMT6 mouse mammary tumors in vivo
    • Rockwell, S. Effects of mitomycin C alone and in combination with X-rays on EMT6 mouse mammary tumors in vivo. J. Natl. Cancer Inst., 71: 765-771, 1983.
    • (1983) J. Natl. Cancer Inst. , vol.71 , pp. 765-771
    • Rockwell, S.1
  • 26
    • 0018642880 scopus 로고
    • Combination therapy with radiation and mitomycin C: preliminary results with EMT6 tumor cells in vitro and in vivo
    • Rockwell, S., and Kennedy, K. A. Combination therapy with radiation and mitomycin C: preliminary results with EMT6 tumor cells in vitro and in vivo. Int. J. Radiat. Oncol. Biol. Phys., 5: 1673-1676, 1979.
    • (1979) Int. J. Radiat. Oncol. Biol. Phys. , vol.5 , pp. 1673-1676
    • Rockwell, S.1    Kennedy, K.A.2
  • 27
    • 0019995383 scopus 로고
    • Mitomydn C as a prototype bioreductive alkylating agent: in vitro studies of metabolism and cytotoxicity
    • Rockwell, S., Kennedy, K. A., and Sartorelli, A. C. Mitomydn C as a prototype bioreductive alkylating agent: in vitro studies of metabolism and cytotoxicity. Int. J. Radtot. Oncol. Biol. Phys., 8. 753-755, 1982.
    • (1982) Int. J. Radtot. Oncol. Biol. Phys. , vol.8 , pp. 753-755
    • Rockwell, S.1    Kennedy, K.A.2    Sartorelli, A.C.3
  • 28
    • 0000231792 scopus 로고
    • Pharmacology of mitomydn C. III. In vitro metabolism by rat liver
    • Schwartz, H. S. Pharmacology of mitomydn C. III. In vitro metabolism by rat liver. J. Pharmacol. Exp. Ther., 136: 250-258, 1962.
    • (1962) J. Pharmacol. Exp. Ther. , vol.136 , pp. 250-258
    • Schwartz, H.S.1
  • 29
    • 0014059118 scopus 로고
    • An electron-transport system associated with the outer membrane of liver mitochondria. A biochemical and morphological study
    • Sottocasa, G. L., Kuylenstiema, T., Emster, L., and Bergstand, A. An electron-transport system associated with the outer membrane of liver mitochondria. A biochemical and morphological study. J. Cell Biol., 32: 415-438, 1967.
    • (1967) J. Cell Biol. , vol.32 , pp. 415-438
    • Sottocasa, G.L.1    Kuylenstiema, T.2    Emster, L.3    Bergstand, A.4
  • 30
    • 0020440918 scopus 로고
    • The metabolism of menadione (2-methyl-1, 4-naphthoquinone) by isolated hepatocytes. A study of the implications of oxidative stress in intact cells
    • Thor, H., Smith, M. T., Hartzell, P., Bellomo, G., Jewell, S. A., and Orrenius, S. The metabolism of menadione (2-methyl-1, 4-naphthoquinone) by isolated hepatocytes. A study of the implications of oxidative stress in intact cells. J. Biol. Chem., 257: 12419-12425, 1982.
    • (1982) J. Biol. Chem. , vol.257 , pp. 12419-12425
    • Thor, H.1    Smith, M.T.2    Hartzell, P.3    Bellomo, G.4    Jewell, S.A.5    Orrenius, S.6
  • 31
    • 0019835111 scopus 로고
    • Reductive metabolism and alkylating activity of mitomydn C induced by rat liver microsomes
    • Tomasz, M., and Lipman, R. Reductive metabolism and alkylating activity of mitomydn C induced by rat liver microsomes. Biochemistry, 20: 5056-5061, 1981.
    • (1981) Biochemistry , vol.20 , pp. 5056-5061
    • Tomasz, M.1    Lipman, R.2
  • 32
    • 0016226773 scopus 로고
    • The mode of interaction of mitomydn C with deoxyribonucleic add and other polynucleotides in vitro
    • Tomasz, M., Mercado, C. M., Olson, J., and Chatterjie, N. The mode of interaction of mitomydn C with deoxyribonucleic add and other polynucleotides in vitro. Biochemistry, 73: 4878-4887, 1974.
    • (1974) Biochemistry , vol.73 , pp. 4878-4887
    • Tomasz, M.1    Mercado, C.M.2    Olson, J.3    Chatterjie, N.4
  • 33
    • 0015986836 scopus 로고
    • Interrelationships of some chemical, physicochemical, and biological activities of several 1-(2-haloethyl)-1-nitrosoureas
    • Wheeler, G. P., Bowdon, B. J., Gremsley, J. A., and Lloyd, H. H. Interrelationships of some chemical, physicochemical, and biological activities of several 1-(2-haloethyl)-1-nitrosoureas. Cancer Res., 34: 194-200, 1974.
    • (1974) Cancer Res. , vol.34 , pp. 194-200
    • Wheeler, G.P.1    Bowdon, B.J.2    Gremsley, J.A.3    Lloyd, H.H.4
  • 34
    • 0017088267 scopus 로고
    • Some properties of a detergent-solubilized NADPH-cytochrome c (cytochrome P-450) reductase purified by biospecific affinity chromatography
    • Yasukochi, Y., and Masters, B. S. S. Some properties of a detergent-solubilized NADPH-cytochrome c (cytochrome P-450) reductase purified by biospecific affinity chromatography. J. Bid. Chem., 251: 5337-5344, 1976.
    • (1976) J. Bid. Chem. , vol.251 , pp. 5337-5344
    • Yasukochi, Y.1    Masters, B.S.S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.